Protein Alignment Ret and Ret

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_036775.2
• Gene: Ret / 24716
• RGDID: 3556
• Length: 1115
• Species: Rattus norvegicus
• Alignment Length: 1258
• Identity: 376/1258 - (29%)
• Similarity: 527/1258 - (41%)
• Gaps: 342/1258 - (27%)

  Fly    51 PLAQFQVLRMEDNRLAS----DYLYS-----LEQNPLLRINSSSGEIYMRTDYRSPNSSATFLVT 106
            ||.....||.....:.|    .|||.     |.:|..:.|:|.:|.:|:       |.|.
  Rat    49 PLLYVHALRDAPGEVPSFRLGQYLYGVYRTRLHENDWIHIDSGTGLLYL-------NQSL----- 101

  Fly   107 AFPRDQPDHELLNVSHLSLEVTPQPLEEY---CSELEHICFW----------------------- 145
                |....|.|::.:....:....|:.:   .::.|..|.|
  Rat   102 ----DHSSWEQLSIRNGGFPLLTVFLQVFLGSTAQREGECHWPGCARVYFSFINDTFPNCSSFKA 162

  Fly   146 -------SSAQYTIAESHGPYRRKDFFE----PVLIGALNSRAAKYLCPHVSLEYSLNAGSS-HF 198
                   :...:.|.|:..|   ..|::    ||          ::|||::|::|.|..|.. .|
  Rat   163 RDLCTPETGVSFRIRENRPP---GTFYQFRMLPV----------QFLCPNISVKYKLLEGDGLPF 214

  Fly   199 VLKQN--RLYTRQTLDHD--ELNGLNAKAGQLQARITCTVKLSSRDQRKFSRILDIKLLDRNDNG 259
            ....:  .:.||..||.:  |...|.|:         |.|.....::.|.:....:.:.|.:|:.
  Rat   215 RCDPDCLEVSTRWALDRELQEKYVLEAE---------CAVAGPGANKEKVAVSFPVTVYDEDDSP 270

  Fly   260 PKLQESSSKFDFYLEQPYFQADEEAGKKVIYV-DKDTLEANAHLVYAVHNDSHGLFRPDCHA--- 320
            |............:|   |:..|......:.| |.|.:.|:..|   |...:..|...|..|
  Rat   271 PTFSGGVGTASAVVE---FKRKEGTVVATLQVFDADVVPASGEL---VRRYTSTLLSGDSWAQQT 329

  Fly   321 YEADHTGRPHTIVSCQLRFSRNGVFRETPYCVSL---------EARDLTIVSRV---DAMSATAN 373
            :..:||.. .|:|.     |.|...|.|.:...|         |:|.|.:|..|   |.....:.
  Rat   330 FRVEHTPN-ETLVQ-----SNNNSVRATMHNYKLVLNRSLSISESRVLQLVVLVNDSDFQGPGSG 388

  Fly   374 VCY-HINLSKLHESEQELPQA--LPLRARQHR--------IFESEEFNGDSAGRSLSPPTVDYDK 427
            |.: |.|:|.|..: ..||.|  .|:..|..|        :...:||:|.|....|.|.:.:
  Rat   389 VLFLHFNVSVLPVT-LNLPMAYSFPVNRRARRYAQIGKVCVENCQEFSGVSIQYKLQPSSTN--- 449

  Fly   428 DVSVYRSAASNFRVVQPDSFLDLMRLRSIRFDIVEDKLGAFGITS----TSGIVFVKNPQVLE-- 486
                                                 ..|.|:.:    |||.::|.:.:.|.
  Rat   450 -------------------------------------CSALGVVTSTEDTSGTLYVNDTEALRRP 477

  Fly   487 EAPETIYFLNVTWIDQQRLSHVRVINVHLVHGR--PENTSCELKVKSRSQTCAQIKYQSQCVRYC 549
            |..|..|.:..|  |:|.....:...|..|.|.  .|...|       .::||..|.:.:|....
  Rat   478 ECTELQYTVVAT--DRQTRRQTQASLVVTVEGTYIAEEVGC-------PKSCAVNKRRPECEECG 533

  Fly   550 GLATGGGSCQWRGSNSAMFGTRYGSCVPESRYCPDHVCDPLEELNPMACPQDCTPAGRIVGPHSS 614
            ||.:..|.|:||..:.......:.:|.|.:|.|||..||.||..:...|||||. .|.|||.|..
  Rat   534 GLGSPTGRCEWRQGDGKGITRNFSTCSPSTRTCPDGHCDALESRDINICPQDCL-RGPIVGGHER 597

  Fly   615 NENKRGIYSASGTCIC-EDNGKCSCAPLDEEPKMKKPRKRKNETEAEPLLGVRRGTPPNQPLQDP 678
            .| ::||.:..|.|.| .|..||.|.|.|.                                |.|
  Rat   598 GE-RQGIKAGYGICNCFPDEKKCFCEPEDS--------------------------------QGP 629

  Fly   679 MLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLL----------------IAQRKMLQRRLGK 727
            :           ||..|. .|||..:||..::..||                ||..:|...|
  Rat   630 L-----------CDELCR-TVITAAVLFSFIISVLLSTFCIHRYHKHAHKPPIASAEMTFCR--- 679

  Fly   728 QSMTTSSKQALPESGGGDFALMPLQSGFRFES----------------GDAKWEFPREKLQLDTV 776
                       |..|   |.:....||.|..|                .|.||||||:.|.|...
  Rat   680 -----------PAQG---FPISYSSSGTRRPSLDSMENQVSVDSFKIPEDPKWEFPRKNLVLGKT 730

  Fly   777 LGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPNVIKLLGAC 841
            |||||||:|:|..|..:.|..|.|||||||||:.::..|...|||||.||::|:||:||||.|||
  Rat   731 LGEGEFGKVVKATAFRLKGRAGYTTVAVKMLKENASQSELRDLLSEFNLLKQVNHPHVIKLYGAC 795

  Fly   842 TSSEAPLLIIEYARYGSLRSYLRLSRKI-----------ECAGVDFADGVEPVNVKMVLT----- 890
            :.....|||:|||:|||||.:||.||||           ..:.:|..|       :.|||
  Rat   796 SQDGPLLLIVEYAKYGSLRGFLRDSRKIGPAYVSSGGSRNSSSLDHPD-------ERVLTMGDLI 853

  Fly   891 -FAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKW 954
             |||||.:||.||:|:|||||||||||:|:|:|:..|||||||:|||||:|:|:|:|:.|:||||
  Rat   854 SFAWQISRGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKKSKGRIPVKW 918

  Fly   955 MAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYS 1019
            ||.|||.||:||::|||||||||.||::|||.:|||||.|:.|::|||||:||:||:||||.:|.
  Rat   919 MAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYR 983

  Fly  1020 IVRTCWADEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAVSNPLYCGDDSALITTELGE----- 1079
            ::..||..||:.||.|..::.:.||::..:..|:||..:..|:.|...|..:...|.|.:
  Rat   984 LMLQCWKQEPDKRPVFADISKDLEKMMVKSRDYLDLAASTPSDSLLYDDGLSEEETPLVDCNSAP 1048

  Fly  1080 -PESLQHLWSPPKIAYDIHDQATSYDQSEEEMPVTSTAPPGYDLPRPLLDATANGQVLRYENDLR 1143
             |.||...|...|:          |..|:...|..|..|    |.|  .|.|:.| ..||.||
  Rat  1049 LPRSLPSTWIENKL----------YGMSDPNWPGESPVP----LTR--ADGTSTG-FPRYAND-- 1094

  Fly  1144 FPLNIRKSSCTPSYSNMTSEPPA 1166
                       ..|:|....|.|
  Rat  1095 -----------SVYANWMVSPSA 1106

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	161/295 (55%)
Ret	NP_036775.2	RET_CLD1	29..154	CDD:465485	25/146 (17%)
		Cadherin-like region 1 (CLD1). /evidence=ECO:0000250|UniProtKB:P07949	29..153		24/145 (17%)
		Cadherin	173..248	CDD:394985	18/79 (23%)
		Cadherin-like region 3 (CLD3). /evidence=ECO:0000250|UniProtKB:P07949	266..380		30/130 (23%)
		RET_CLD3	266..380	CDD:465516	30/130 (23%)
		Cadherin-like region 4 (CLD4). /evidence=ECO:0000250|UniProtKB:P07949	406..507		19/106 (18%)
		RET_CLD4	408..507	CDD:465517	17/104 (16%)
		PTKc_RET	724..1013	CDD:173631	163/321 (51%)