Protein Alignment Ret and FRK

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_002022.1
• Gene: FRK / 2444
• HGNCID: 3955
• Length: 505
• Species: Homo sapiens
• Alignment Length: 294
• Identity: 109/294 - (37%)
• Similarity: 161/294 - (54%)
• Gaps: 22/294 - (7%)

  Fly   763 KWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQ 827
            :||..|..:||...||.|:||:|.:|...      ..|.||||.||.|  |::....|.|.|:::
Human   226 QWEIDRNSIQLLKRLGSGQFGEVWEGLWN------NTTPVAVKTLKPG--SMDPNDFLREAQIMK 282

  Fly   828 EVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFA 892
            .:.||.:|:|...||..:...:|.|..|:|||:.||:            .|....:::...:..|
Human   283 NLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQ------------NDTGSKIHLTQQVDMA 335

  Fly   893 WQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTR--DVYEDDAYLKRSRDRVPVKWM 955
            .|:..|||||.....:||||||||||:.:..|.|::||||.|  .|..:|.|..|...::||||.
Human   336 AQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWT 400

  Fly   956 APESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSI 1020
            |||::..:.::.||||||||:|.:|:||.|..||.|:....:..:|...||:.:|.||.:..|:|
Human   401 APEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNI 465

  Fly  1021 VRTCWADEPNGRPSFKFLASEFEKLLGNNAKYID 1054
            :..||..||..||:|:.|..:.|.....::.|.|
Human   466 MLECWNAEPKERPTFETLRWKLEDYFETDSSYSD 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	104/280 (37%)
FRK	NP_002022.1	SH3_Src_like	47..104	CDD:212779
		SH2_Src_Frk	112..207	CDD:199831
		PTKc_Frk_like	225..494	CDD:270653	107/287 (37%)