DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ret and Lmtk2

DIOPT Version :10

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_001074578.1 Gene:Lmtk2 / 231876 MGIID:3036247 Length:1471 Species:Mus musculus


Alignment Length:642 Identity:156/642 - (24%)
Similarity:251/642 - (39%) Gaps:151/642 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly   670 PPNQPLQDPMLLGVLNVAGFECDRSCMF--------FVITCPLLFVLLLLC------LLIA---- 716
            ||..|....:||.:|...|  |.|:...        .|:..|.|||:|.:|      :|||    
Mouse     4 PPASPPPPMLLLLLLLTVG--CARAAPLPQTGAGEVPVVEVPSLFVILSVCSLLILIVLIANCVS 66

  Fly   717 -------QRKMLQRRLGKQSMTTSSKQALP--ESGGGDFAL------MPLQSGFRFESGDAKWEF 766
                   ..|..:.....:...|...:..|  :|....|.|      :|..|.|:......|.:.
Mouse    67 CCKDPEIDFKEFEDNFDDEIDFTPPAEDTPSIQSPAEVFTLSVPNISLPAPSQFQASVEGLKSQV 131

  Fly   767 PREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSH 831
            .|..|.....:|.|.||:||.|   |......:..|.||.||..::..|....|...:....:.|
Mouse   132 ARHSLNYIQEIGSGWFGKVLLG---ETYTGTSVARVIVKELKVSASPKEQDTFLKSGEPYYILQH 193

  Fly   832 PNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVL-TFAWQI 895
            |||::.:|.|..:...||:.|:...|.|::||...:          :.|...:..|:| ..|.:|
Mouse   194 PNVLQCVGQCVEAIPYLLVFEFCDLGDLKAYLHNEQ----------EHVRGDSQTMLLQRMACEI 248

  Fly   896 CKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRV-PVKWMAPE- 958
            ..|:|.:.:|..:|.|||.||..|......|:.|:|:....|::| |::....:| |::|.||| 
Mouse   249 AAGLAAMHKLHFLHSDLALRNCYLTSDLNVKVGDYGIGFSRYKED-YIETDDKKVFPLRWTAPEL 312

  Fly   959 --SLADHVYTSK----SDVWSFGVLCWELITLGASPYPGIAPQNLWS--LLKTGYRMDRP---EN 1012
              |..|.:.|:.    |::||.||..|||....|.||..::..::.:  :.:...::.:|   :.
Mouse   313 VTSFQDRLLTADQTKYSNIWSLGVTLWELFNNAAQPYANLSDLDVLNQVIRERDMKLPKPQLEQP 377

  Fly  1013 CSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLL------GNNAKYIDLE--------------- 1056
            .|:..|.:::.||. .|:.||:    |.:..:||      ......:|.|               
Mouse   378 YSDRWYEVLQFCWL-PPDKRPA----AEDVHRLLTYLRMQSQRDSEVDFEQQWTALKPDTNSRDA 437

  Fly  1057 TNAVSNPL---YCGD------DSALITTELGEPESLQHLWSPPKIAYDIH---------DQATSY 1103
            :::.:.|:   :..|      :..|..||..:..|.:::|...|  :| |         |:|.||
Mouse   438 SSSAAFPILDHFARDRLGREMEEVLTVTETSQGLSFEYVWEAAK--HD-HFDEQGRGHPDEALSY 499

  Fly  1104 ----------------------DQSEEEMPVTSTAPPGYDLPRPLLDATANGQVLRYENDLRFPL 1146
                                  |.|.:|:||.:   ||.   .|:.||    ..|...:|....|
Mouse   500 SSMFFPVEVFENSLSDPGPGKQDDSGQEVPVRA---PGV---VPVFDA----HNLSVGSDYYIQL 554

  Fly  1147 NIRKSSCTPSYSNMTSEPPA--TTSLPHYS-VPVKRGRSYLDMTNKSLIPDNLDSRE 1200
            . .|||     ||:..:|||  ||.:.... ...:..|:..|....|..|....|.|
Mouse   555 E-EKSS-----SNLGLDPPALLTTEVDKLERAGAEEPRTEEDFFQSSAHPKEASSTE 605

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864 81/298 (27%)
Lmtk2NP_001074578.1 PTKc_Aatyk2 138..408 CDD:270669 80/288 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 510..530 3/19 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 580..615 6/26 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 761..814
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 885..1197
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1248..1292
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1342..1434
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1452..1471
Blue background indicates that the domain is not in the aligned region.

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