DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ret and FGFR2

DIOPT Version :9

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:XP_006717771.1 Gene:FGFR2 / 2263 HGNCID:3689 Length:839 Species:Homo sapiens


Alignment Length:545 Identity:187/545 - (34%)
Similarity:277/545 - (50%) Gaps:114/545 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   610 GPHSSNENKRGIYSA----SGTCICEDN---GKCS-CAPLDEEPKMKKPRKRKNETEAEPLLGVR 666
            |.:|||.....:::.    :|..||:.:   |:.: .|.|...||.:.|.:.| |..|.|     
Human   335 GINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREK-EITASP----- 393

  Fly   667 RGTPPNQPLQDPMLLGVLNVAGFECDRSCM-FFVITCPLLFVLLLLCLL---------------- 714
                           ..|.:|.:     |: .|:|.|  :.|.::||.:                
Human   394 ---------------DYLEIAIY-----CIGVFLIAC--MVVTVILCRMKNTTKKPDFSSQPAVH 436

  Fly   715 -IAQRKMLQRRLGKQSMTT-SSKQALPE-----SGGGDFALMPLQSGFRFESGDAKWEFPREKLQ 772
             :.:|..|:|::..:|.:: :|...|..     |...|..::...|.:.... |.||||||:||.
Human   437 KLTKRIPLRRQVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPE-DPKWEFPRDKLT 500

  Fly   773 LDTVLGEGEFGQVLKGFATEIAGL-----PGITTVAVKMLKKGSNSVEYMALLSEFQLLQEV-SH 831
            |...||||.||||:   ..|..|:     ....||||||||..:...:...|:||.::::.: .|
Human   501 LGKPLGEGCFGQVV---MAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIGKH 562

  Fly   832 PNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGV-----EPVNVKMVLTF 891
            .|:|.||||||......:|:|||..|:||.|||..|.   .|::::..:     |.:..|.:::.
Human   563 KNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP---PGMEYSYDINRVPEEQMTFKDLVSC 624

  Fly   892 AWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMA 956
            .:|:.:||.||:..|.:||||||||||:.:..:.||:||||.||:...|.|.|.:..|:||||||
Human   625 TYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMA 689

  Fly   957 PESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIV 1021
            ||:|.|.|||.:|||||||||.||:.|||.||||||..:.|:.|||.|:|||:|.||:..:|.::
Human   690 PEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYMMM 754

  Fly  1022 RTCWADEPNGRPSFKFLASEFEKL--LGNNAKYIDLETNAVSNPL------------YC--GDDS 1070
            |.||...|:.||:||.|..:.:::  |..|.:|:||     |.||            .|  ||||
Human   755 RDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDL-----SQPLEQYSPSYPDTRSSCSSGDDS 814

  Fly  1071 ALITTELGEPESLQHLWSPPKIAYD 1095
                           ::||..:.|:
Human   815 ---------------VFSPDPMPYE 824

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 PKc_like 770..1049 CDD:304357 130/291 (45%)
TyrKc 771..1042 CDD:197581 128/281 (46%)
FGFR2XP_006717771.1 Ig1_FGFR 66..143 CDD:143174
IG_like 66..143 CDD:214653
Ig2_FGFR 183..267 CDD:143265
IG_like 282..376 CDD:214653 10/40 (25%)
Ig3_FGFR 290..377 CDD:143175 10/41 (24%)
PTKc_FGFR2 474..786 CDD:270679 140/318 (44%)
Pkinase_Tyr 499..775 CDD:285015 128/281 (46%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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