DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ret and FGFR2

DIOPT Version :10

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_075259.4 Gene:FGFR2 / 2263 HGNCID:3689 Length:822 Species:Homo sapiens


Alignment Length:547 Identity:186/547 - (34%)
Similarity:276/547 - (50%) Gaps:116/547 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   610 GPHSSNENKRGIYSA----SGTCICEDN---GKCS-CAPLDEEPKMKKPRKRKNETEAEPLLGVR 666
            |.:|||.....:::.    :|..||:.:   |:.: .|.|...||.:.|.:.| |..|.|     
Human   316 GINSSNAEVLALFNVTEADAGEYICKVSNYIGQANQSAWLTVLPKQQAPGREK-EITASP----- 374

  Fly   667 RGTPPNQPLQDPMLLGVLNVAGFECDRSCM-FFVITCPLLFVLLLLCLL---------------- 714
                           ..|.:|.:     |: .|:|.|  :.|.::||.:                
Human   375 ---------------DYLEIAIY-----CIGVFLIAC--MVVTVILCRMKNTTKKPDFSSQPAVH 417

  Fly   715 -IAQRKMLQRRLGKQSMTTSSKQALPE--------SGGGDFALMPLQSGFRFESGDAKWEFPREK 770
             :.:|..|:|::...:.::||..:...        |...|..::...|.:.... |.||||||:|
Human   418 KLTKRIPLRRQVTVSAESSSSMNSNTPLVRITTRLSSTADTPMLAGVSEYELPE-DPKWEFPRDK 481

  Fly   771 LQLDTVLGEGEFGQVLKGFATEIAGL-----PGITTVAVKMLKKGSNSVEYMALLSEFQLLQEV- 829
            |.|...||||.||||:   ..|..|:     ....||||||||..:...:...|:||.::::.: 
Human   482 LTLGKPLGEGCFGQVV---MAEAVGIDKDKPKEAVTVAVKMLKDDATEKDLSDLVSEMEMMKMIG 543

  Fly   830 SHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGV-----EPVNVKMVL 889
            .|.|:|.||||||......:|:|||..|:||.|||..|.   .|::::..:     |.:..|.::
Human   544 KHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRP---PGMEYSYDINRVPEEQMTFKDLV 605

  Fly   890 TFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKW 954
            :..:|:.:||.||:..|.:||||||||||:.:..:.||:||||.||:...|.|.|.:..|:||||
Human   606 SCTYQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKW 670

  Fly   955 MAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYS 1019
            ||||:|.|.|||.:|||||||||.||:.|||.||||||..:.|:.|||.|:|||:|.||:..:|.
Human   671 MAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTNELYM 735

  Fly  1020 IVRTCWADEPNGRPSFKFLASEFEKL--LGNNAKYIDLETNAVSNPL------------YC--GD 1068
            ::|.||...|:.||:||.|..:.:::  |..|.:|:||     |.||            .|  ||
Human   736 MMRDCWHAVPSQRPTFKQLVEDLDRILTLTTNEEYLDL-----SQPLEQYSPSYPDTRSSCSSGD 795

  Fly  1069 DSALITTELGEPESLQHLWSPPKIAYD 1095
            ||               ::||..:.|:
Human   796 DS---------------VFSPDPMPYE 807

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864 130/291 (45%)
FGFR2NP_075259.4 IgI_1_FGFR 31..124 CDD:409362
Ig strand A 31..34 CDD:409362
Ig strand A' 47..53 CDD:409362
Ig strand B 56..66 CDD:409362
Ig strand C 69..74 CDD:409362
Ig strand C' 77..79 CDD:409362
Ig strand D 84..88 CDD:409362
Ig strand E 91..96 CDD:409362
Ig strand F 102..111 CDD:409362
Ig strand G 114..124 CDD:409362
IgI_2_FGFR 154..248 CDD:409443
Ig strand A 154..157 CDD:409443
Ig strand A' 165..170 CDD:409443
Ig strand B 174..182 CDD:409443
Ig strand C 188..193 CDD:409443
Ig strand C' 196..198 CDD:409443
Ig strand D 207..210 CDD:409443
Ig strand E 214..219 CDD:409443
Ig strand F 228..235 CDD:409443
Ig strand G 238..248 CDD:409443
Ig 256..358 CDD:472250 10/41 (24%)
Ig strand B 274..278 CDD:409353
Ig strand C 287..291 CDD:409353
Ig strand E 323..327 CDD:409353 0/3 (0%)
Ig strand F 337..342 CDD:409353 2/4 (50%)
Ig strand G 350..353 CDD:409353 0/2 (0%)
PTKc_FGFR2 457..769 CDD:270679 140/318 (44%)
Blue background indicates that the domain is not in the aligned region.

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