Protein Alignment Ret and Yes1

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_033561.1
• Gene: Yes1 / 22612
• MGIID: 99147
• Length: 541
• Species: Mus musculus
• Alignment Length: 287
• Identity: 109/287 - (37%)
• Similarity: 164/287 - (57%)
• Gaps: 26/287 - (9%)

  Fly   760 GDAK--WEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSE 822
            |.||  ||.|||.|:|:..||:|.||:|..|...      |.|.||:|.||.|:...|  |.|.|
Mouse   262 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWN------GTTKVAIKTLKPGTMMPE--AFLQE 318

  Fly   823 FQLLQEVSHPNVIKLLGACTSSEAPLLII-EYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVK 886
            .|:::::.|..::.|....  ||.|:.|: |:...|||..:|:           ..|| :.:.:.
Mouse   319 AQIMKKLRHDKLVPLYAVV--SEEPIYIVTEFMSKGSLLDFLK-----------EGDG-KYLKLP 369

  Fly   887 MVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVP 951
            .::..|.||..||||:..:..:||||.|.|:|:.:..||||:||||.| :.||:.|..|...:.|
Mouse   370 QLVDMAAQIADGMAYIERMNYIHRDLRAANILVGENLICKIADFGLAR-LIEDNEYTARQGAKFP 433

  Fly   952 VKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEA 1016
            :||.|||:.....:|.||||||||:|..||:|.|..||||:..:.:...::.||||..|:.|.|:
Mouse   434 IKWTAPEAALYGRFTIKSDVWSFGILQTELVTKGRVPYPGMVNREVLEQVERGYRMPCPQGCPES 498

  Fly  1017 VYSIVRTCWADEPNGRPSFKFLASEFE 1043
            ::.::..||..:|:.||:|:::.|..|
Mouse   499 LHELMNLCWKKDPDERPTFEYIQSFLE 525

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	101/275 (37%)
Yes1	NP_033561.1	SH3_Yes	92..149	CDD:212940
		SH2_Src_family	152..251	CDD:199827
		PTKc_Yes	262..540	CDD:270654	109/287 (38%)