Protein Alignment Ret and FES

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001996.1
• Gene: FES / 2242
• HGNCID: 3657
• Length: 822
• Species: Homo sapiens
• Alignment Length: 994
• Identity: 228/994 - (22%)
• Similarity: 356/994 - (35%)
• Gaps: 301/994 - (30%)

  Fly   134 EYCSELEHICFWSSAQYTIAESHGPYRRKDFFEPVL-----IGALNSRAAKYLCPHVSLEYSLNA 193
            ||...|.|:        ::.:|.|..|......|:.     |.:.....::.|..|..   .||:
Human    43 EYAGLLHHM--------SLQDSGGQSRAISPDSPISQSWAEITSQTEGLSRLLRQHAE---DLNS 96

  Fly   194 G--SSHFVLKQNRLYTRQTLDHDELNGLNAKAGQLQARITCTVKLSSRDQRKFSRILDIKLLDRN 256
            |  |...:|.:.|...|:|        .:.:..|||..:|   |..|:|..|..........|..
Human    97 GPLSKLSLLIRERQQLRKT--------YSEQWQQLQQELT---KTHSQDIEKLKSQYRALARDSA 150

  Fly   257 DNGPKLQESSSKFDFYLEQPYFQADEEAGKKVIYVDKDTLEANAHLVYAVHNDSHGLFRPDCHAY 321
            ....|.||:|.             |::..|.     ||....:...::|.||    .:.....|.
Human   151 QAKRKYQEASK-------------DKDRDKA-----KDKYVRSLWKLFAHHN----RYVLGVRAA 193

  Fly   322 EADHTGRPHTIVSCQLRFSRNGVFRETPYCVSLEARDLTIVSRVDAMSATANVCYHINLSKLHES 386
            :..|......::...||..::  ..|...|:..|     |:..            ::.:|.|.:.
Human   194 QLHHQHHHQLLLPGLLRSLQD--LHEEMACILKE-----ILQE------------YLEISSLVQD 239

  Fly   387 E-----QELPQALPLRARQHRIFESEEFNG---DSAGRSLSPPTVDYDKDVSVYRSAASNFRVVQ 443
            |     :|:..|..      ||....|:.|   ........||.|.:|:      |.......::
Human   240 EVVAIHREMAAAAA------RIQPEAEYQGFLRQYGSAPDVPPCVTFDE------SLLEEGEPLE 292

  Fly   444 PDSF-LDLMRLRSIRFDI--VEDKLGAFGITSTSGIVF------------VKNPQVLEEAPETIY 493
            |... |:.:.:.|::..:  |.|:|..     .:.:||            ::|.:......|.:.
Human   293 PGELQLNELTVESVQHTLTSVTDELAV-----ATEMVFRRQEMVTQLQQELRNEEENTHPRERVQ 352

  Fly   494 FLNVTWIDQQRLSHVRVINVHLVHGRPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSC 558
            .|....:.|:.|..::|                       ..|:|.|.|:|
Human   353 LLGKRQVLQEALQGLQV-----------------------ALCSQAKLQAQ-------------- 380

  Fly   559 QWRGSNSAMFGTRYGSCVPESRYCPDHVCDPLEELNPMACP-----QD---------------CT 603
                  ..:..|:                  ||.|.|...|     ||               .|
Human   381 ------QELLQTK------------------LEHLGPGEPPPVLLLQDDRHSTSSSEQEREGGRT 421

  Fly   604 PAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSC-APLDEEPKMKKPRK--------------- 652
            |...|:..|.|     ||:          ..|.|. .||...|:::||..
Human   422 PTLEILKSHIS-----GIF----------RPKFSLPPPLQLIPEVQKPLHEQLWYHGAIPRAEVA 471

  Fly   653 -----------RKNETEAEPLLGVR-RGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLL 705
                       |:::.:.|.:|.|. .|.|.:..:|....|..|...||.          :.|||
Human   472 ELLVHSGDFLVRESQGKQEYVLSVLWDGLPRHFIIQSLDNLYRLEGEGFP----------SIPLL 526

  Fly   706 FVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMPLQSGFRFESGDAKWEFPREK 770
            ...||         ..|:.|.|:|.....: |:|:.                     ||....|.
Human   527 IDHLL---------STQQPLTKKSGVVLHR-AVPKD---------------------KWVLNHED 560

  Fly   771 LQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPNVI 835
            |.|...:|.|.||:|..|...     ...|.||||..::..........|.|.::|::.||||::
Human   561 LVLGEQIGRGNFGEVFSGRLR-----ADNTLVAVKSCRETLPPDLKAKFLQEARILKQYSHPNIV 620

  Fly   836 KLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQICKGMA 900
            :|:|.||..:...:::|..:.|...::||            .:|.. :.||.:|........||.
Human   621 RLIGVCTQKQPIYIVMELVQGGDFLTFLR------------TEGAR-LRVKTLLQMVGDAAAGME 672

  Fly   901 YLSELKLVHRDLAARNVLLADGKICKISDFGLTRD----VYEDDAYLKRSRDRVPVKWMAPESLA 961
            ||.....:||||||||.|:.:..:.||||||::|:    ||.....|:    :|||||.|||:|.
Human   673 YLESKCCIHRDLAARNCLVTEKNVLKISDFGMSREEADGVYAASGGLR----QVPVKWTAPEALN 733

  Fly   962 DHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWA 1026
            ...|:|:|||||||:|.||..:|||||||.::.|.....::.|.|:..||.|.:||:.::..|||
Human   734 YGRYSSESDVWSFGILLWETFSLGASPYPNLSNQQTREFVEKGGRLPCPELCPDAVFRLMEQCWA 798

  Fly  1027 DEPNGRPSFKFLASEFEKL 1045
            .||..||||..:..|.:.:
Human   799 YEPGQRPSFSTIYQELQSI 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	101/280 (36%)
FES	NP_001996.1	Important for interaction with membranes containing phosphoinositides	1..300		63/331 (19%)
		F-BAR_Fes	7..239	CDD:153369	49/258 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	394..421		3/26 (12%)
		SH2_Fps_family	453..537	CDD:198224	19/102 (19%)
		PTKc_Fes	564..815	CDD:270667	99/272 (36%)