Protein Alignment Ret and FER

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_011541571.1
• Gene: FER / 2241
• HGNCID: 3655
• Length: 837
• Species: Homo sapiens
• Alignment Length: 1030
• Identity: 218/1030 - (21%)
• Similarity: 372/1030 - (36%)
• Gaps: 356/1030 - (34%)

  Fly   133 EEYCSELEHICFWSSAQYTIAESHGPYRRKDFFEPVLIGALNSRAAKYLCPHVSLEYSLNAGSSH 197
            :||.|.|:::|.....:.|:..::.....|.:   :|:.....:.::.:..|..   .||:|..|
Human    40 KEYASTLQNLCNQVDKESTVQMNYVSNVSKSW---LLMIQQTEQLSRIMKTHAE---DLNSGPLH 98

  Fly   198 FVLKQNRLYTRQTLDHDELN----GLNAKAGQLQARITCTVKLSSRDQRKFSRILDIKLLDRNDN 258
                  || |....|..::.    |::.   |::|.:   :|::..:..|........:.:.|..
Human    99 ------RL-TMMIKDKQQVKKSYIGVHQ---QIEAEM---IKVTKTELEKLKCSYRQLIKEMNSA 150

  Fly   259 GPKLQESSSKFDFYLEQPYFQADEEAGKKVIYVDKDTLEANAHLVYAVHNDSHGLFRPDCHAYEA 323
            ..|.:|:.:|            .:|..|.....||.|::     ::.:||.
Human   151 KEKYKEALAK------------GKETEKAKERYDKATMK-----LHMLHNQ-------------- 184

  Fly   324 DHTGRPHTIVSCQLRFSRNGVFRETPYCVSLEARDLTIVSRVDAMSATANVCYHINLSKLHESEQ 388
                                      |.::|:...|           ..|..|.|.|..|.:|.|
Human   185 --------------------------YVLALKGAQL-----------HQNQYYDITLPLLLDSLQ 212

  Fly   389 ELPQALPLRARQHRIFE---------SEEFNGDSAGRSLS----PPTVDYDKDVSVYRSAASNFR 440
            ::.:.: ::|.: .||:         :||.........:|    .|:.:|:..:.|:|:.|:..:
Human   213 KMQEEM-IKALK-GIFDEYSQITSLVTEEIVNVHKEIQMSVEQIDPSTEYNNFIDVHRTTAAKEQ 275

  Fly   441 VVQPDSFL----DLMRLRSIRFDIVEDKLGAFGITSTSGIVFVKNPQVLEEAPETIYFLNVTWID 501
            .::.|:.|    :.::...|.::         .:|:.|..|.:|.  :.||..:|
Human   276 EIEFDTSLLEENENLQANEIMWN---------NLTAESLQVMLKT--LAEELMQT---------- 319

  Fly   502 QQRLSHVRVINVHLVHGRPENTSCELKVKSRSQTCAQ------IKYQSQCVRYCGLATGGGSCQW 560
            ||.|.:.....:.|          |.:::..|:||.:      :..|.|.
Human   320 QQMLLNKEEAVLEL----------EKRIEESSETCEKKSDIVLLLSQKQA--------------- 359

  Fly   561 RGSNSAMFGTRYGSCVPESRYCPDHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSAS 625
                                         ||||........||.| :........|.|
Human   360 -----------------------------LEELKQSVQQLRCTEA-KFSAQKELLEQK------- 387

  Fly   626 GTCICEDNGKCSCAPLDEEPKM--------------KKPRKRKNETEAEPLLGVRRGTPPNQPLQ 676
               :.|::||       |.|.:              :|.|..|.|:....:.|:.|.  |...|.
Human   388 ---VQENDGK-------EPPPVVNYEEDARSVTSMERKERLSKFESIRHSIAGIIRS--PKSALG 440

  Fly   677 DPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQR--------RLGKQSMTTS 733
            ...|..:::                             |:::.:.::        |:..|.:.
Human   441 SSALSDMIS-----------------------------ISEKPLAEQDWYHGAIPRIEAQELL-- 474

  Fly   734 SKQA---LPESGG--GDFALMPLQSG-------------FRFE---------------------- 758
            .||.   :.||.|  |::.|.....|             :|||
Human   475 KKQGDFLVRESHGKPGEYVLSVYSDGQRRHFIIQYVDNMYRFEGTGFSNIPQLIDHHYTTKQVIT 539

  Fly   759 --SG---------DAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSN 812
              ||         |.||....|.:.|..:||:|.||:|.||      .|...|:||||..|:...
Human   540 KKSGVVLLNPIPKDKKWILSHEDVILGELLGKGNFGEVYKG------TLKDKTSVAVKTCKEDLP 598

  Fly   813 SVEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFA 877
            ....:..|.|.::|::..|||::||:|.||..:...:|:|....|...::||..:
Human   599 QELKIKFLQEAKILKQYDHPNIVKLIGVCTQRQPVYIIMELVSGGDFLTFLRRKK---------- 653

  Fly   878 DGVEPVNVKMVLTFAWQICKGMAYLSELKLVHR---------------DLAARNVLLADGKICKI 927
               :.:.:|.::.|:.....||.||.....:||               ||||||.|:.:..:.||
Human   654 ---DELKLKQLVKFSLDAAAGMLYLESKNCIHRLCEGKGEMKETSNLGDLAARNCLVGENNVLKI 715

  Fly   928 SDFGLTRDVYED-DAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPG 991
            ||||::|.  || ..|......::|:||.|||:|....|:|:|||||||:|.||..:||..||||
Human   716 SDFGMSRQ--EDGGVYSSSGLKQIPIKWTAPEALNYGRYSSESDVWSFGILLWETFSLGVCPYPG 778

  Fly   992 IAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLL 1046
            :..|.....::.||||..|::|.|.:..|:..||..:|..||.|    ||.:|.|
Human   779 MTNQQAREQVERGYRMSAPQHCPEDISKIMMKCWDYKPENRPKF----SELQKEL 829

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	101/293 (34%)
FER	XP_011541571.1	F-BAR_Fer	5..238	CDD:153370	46/286 (16%)
		SMC_prok_B	107..>393	CDD:274008	67/447 (15%)
		SH2_Fps_family	453..538	CDD:198224	13/86 (15%)
		Protein Kinases, catalytic domain	566..831	CDD:473864	100/289 (35%)