Protein Alignment Ret and Tec

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001106931.1
• Gene: Tec / 21682
• MGIID: 98662
• Length: 630
• Species: Mus musculus
• Alignment Length: 314
• Identity: 102/314 - (32%)
• Similarity: 160/314 - (50%)
• Gaps: 40/314 - (12%)

  Fly   739 PESGGGDFALMPLQSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKG-FATEIAGLPGITTV 802
            |.|..|..|  |..:||.::    |||....:|.....||.|.||.|..| :..:.       .|
Mouse   343 PVSTKGKNA--PTTAGFSYD----KWEINPSELTFMRELGSGLFGVVRLGKWRAQY-------KV 394

  Fly   803 AVKMLKKGSNSVEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLR--- 864
            |:|.:::|:...|  ..:.|.:::.:::||.:::|.|.||..:...::.|:...|.|.::||
Mouse   395 AIKAIREGAMCEE--DFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQ 457

  Fly   865 --LSRKIECAGVDFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKI 927
              .||                  .|:|:....:|:||.||.....:||||||||.|:.:..:.|:
Mouse   458 GHFSR------------------DMLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVNEAGVVKV 504

  Fly   928 SDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGI 992
            ||||:.|.|. ||.|...|..:.||||..||......::|||||||||||.||:.|.|..|:...
Mouse   505 SDFGMARYVL-DDQYTSSSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEIFTEGRMPFEKN 568

  Fly   993 APQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLL 1046
            ....:.:::..|:|:.||:..|:.:|.::..||.:.|.|||||:.|....::|:
Mouse   569 TNYEVVTMVTRGHRLHRPKLASKYLYEVMLRCWQERPEGRPSFEDLLRTIDELV 622

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	92/283 (33%)
Tec	NP_001106931.1	PH_Btk	7..148	CDD:269944
		SH3_Tec	182..236	CDD:212838
		SH2_Tec_Itk	239..346	CDD:198259	1/2 (50%)
		PTKc_Tec_Rlk	364..623	CDD:270685	92/287 (32%)