Protein Alignment Ret and Src

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_006499126.1
• Gene: Src / 20779
• MGIID: 98397
• Length: 552
• Species: Mus musculus
• Alignment Length: 295
• Identity: 111/295 - (37%)
• Similarity: 160/295 - (54%)
• Gaps: 42/295 - (14%)

  Fly   760 GDAK--WEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSE 822
            |.||  ||.|||.|:|:..||:|.||:|..|...      |.|.||:|.||.|:.|.|  |.|.|
Mouse   273 GLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWN------GTTRVAIKTLKPGTMSPE--AFLQE 329

  Fly   823 FQLLQEVSHPNVIKLLGACTSSEAPLLII-EYARYGSL--------RSYLRLSRKIECAGVDFAD 878
            .|:::::.|..:::|....  ||.|:.|: ||...|||        ..||||.:.::.:.
Mouse   330 AQVMKKLRHEKLVQLYAVV--SEEPIYIVTEYMNKGSLLDFLKGETGKYLRLPQLVDMSA----- 387

  Fly   879 GVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYL 943
                           ||..||||:..:..|||||.|.|:|:.:..:||::||||.| :.||:.|.
Mouse   388 ---------------QIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLAR-LIEDNEYT 436

  Fly   944 KRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMD 1008
            .|...:.|:||.|||:.....:|.||||||||:|..||.|.|..||||:..:.:...::.||||.
Mouse   437 ARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMP 501

  Fly  1009 RPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFE 1043
            .|..|.|:::.::..||..||..||:|::|.:..|
Mouse   502 CPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLE 536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	103/283 (36%)
Src	XP_006499126.1	SH3_Src	87..159	CDD:212941
		SH2_Src_Src	163..263	CDD:198228
		PTKc_Src	276..552	CDD:270656	109/292 (37%)