Protein Alignment Ret and F23C8.7

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_490975.1
• Gene: F23C8.7 / 184892
• WormBaseID: WBGene00017736
• Length: 417
• Species: Caenorhabditis elegans
• Alignment Length: 320
• Identity: 99/320 - (30%)
• Similarity: 167/320 - (52%)
• Gaps: 44/320 - (13%)

  Fly   764 WEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGS-NSVEYMALLSEFQLLQ 827
            ||....:::|...||||.||:|.||..|...|  .:...|:|..|..| |..:...::.|.:|::
 Worm   113 WEIEHSQVELTKKLGEGAFGEVWKGKLTLKNG--NVENCAIKTAKLESLNKEQIKEIMREARLMR 175

  Fly   828 EVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFA 892
            .:.||||:|..|...|.|...:|:|.|..|:|.|||:.:..:          |....::|:
 Worm   176 NLDHPNVVKFYGVGASQEPLYVIMELADCGALDSYLQKNPNL----------VPDKKMEMI---- 226

  Fly   893 WQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAP 957
            :|...|::|:.|.||:|||:||||.|...|:: ||:||||:|   |..:|:.....:||::|:||
 Worm   227 YQAACGISYMHEKKLLHRDIAARNCLYGGGQV-KIADFGLSR---EGISYVMDLTKKVPIRWLAP 287

  Fly   958 ESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVY---- 1018
            |:|...:|:.|:||::||::.||:...|..|||.:...::...::.||||.     .:.|:
 Worm   288 ETLKAGIYSPKTDVFAFGIMAWEITENGKEPYPDMRVADVVGKVRNGYRMR-----FDPVFVDFR 347

  Fly  1019 ---SIVRTCWADEPNGRPS----FKFLASEFE------KLLGNNAKYIDLETNAVSNPLY 1065
               .:.:.|||:.|..|.|    .::|.:.|.      .:|.:| :..:.|...:..|::
 Worm   348 FGDYVTKHCWAENPADRVSMADVLRYLQTTFGMKPVVLSILSSN-RSTEEEMKTMKPPMF 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	94/296 (32%)
F23C8.7	NP_490975.1	SH2_Fps_family	4..98	CDD:198224
		TyrKc	120..374	CDD:197581	91/278 (33%)