Protein Alignment Ret and egl-15

DIOPT Version :9

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001300356.1
• Gene: egl-15 / 181291
• WormBaseID: WBGene00001184
• Length: 1153
• Species: Caenorhabditis elegans
• Alignment Length: 634
• Identity: 185/634 - (29%)
• Similarity: 277/634 - (43%)
• Gaps: 179/634 - (28%)

  Fly   696 MFFVITCPLLFVLLLLCLLIAQRK-MLQRRLG----KQSMTTSSKQALPESGGGDFALMPLQ--- 752
            :|.::...|..:|.::|.....:| .:...:|    |:.:..|.:....::...|....|.|
 Worm   533 LFLLLAATLFGILFMVCKQTLHKKGFMDDTVGLVARKKRVVVSKRPMNEDNENSDDEPSPYQIQI 597

  Fly   753 -------------------------SGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFAT- 791
                                     |.:..:| |..||..|.||.|..:||||.||:|.|  ||
 Worm   598 IETPITKKEAARKQRKRMNSENTVLSEYEVDS-DPVWEVERSKLSLVHMLGEGAFGEVWK--ATY 659

  Fly   792 ------EIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEV-SHPNVIKLLGACTSSEAPLL 849
                  |||       ||||.||..::..|.:.|:||.:..:.: .|.||::|:|.||.:....:
 Worm   660 KETENNEIA-------VAVKKLKMSAHEKELIDLVSEMETFKVIGEHENVLRLIGCCTGAGPLYV 717

  Fly   850 IIEYARYGSLRSYLRLSR----KIECAGVDFADGVEP--------------VNVKMVLTFAWQIC 896
            ::|..::|:||.:||..|    |.:.:..:..|.:||              :..:.::.||||:.
 Worm   718 VVELCKHGNLRDFLRAHRPKEEKAKKSSQELTDYLEPRKASDKDDIELIPNLTQRHLVQFAWQVA 782

  Fly   897 KGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLA 961
            :||.:|:..|::||||||||||:.||.:.|||||||:|||:.:|.|.||...|:|:||||.|:|.
 Worm   783 QGMNFLASKKIIHRDLAARNVLVGDGHVLKISDFGLSRDVHCNDYYRKRGNGRLPIKWMALEALD 847

  Fly   962 DHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWA 1026
            .:|||.:|||||:|||.||::|||.:|||.||...|::.||.||||:.|..|.:.||.::.:||.
 Worm   848 SNVYTVESDVWSYGVLLWEIMTLGGTPYPTIAMPELYANLKEGYRMEPPHLCPQEVYHLMCSCWR 912

  Fly  1027 DEPNGRPSFKFLASEFEKLLGNNAKYI-------------------------------------- 1053
            ::...|||||.:....:.:|....:.|
 Worm   913 EKLEERPSFKTIVDYLDWMLTMTNETIEGSQEFNDQFFSERSTASGPVSPMESFQKKRKHRPLSA 977

  Fly  1054 --------------DLETNAVSNP------LYCGDD---SALITTE---------LGEPESLQHL 1086
                          |.|:|....|      |||.|:   :.:||.|         |.||....::
 Worm   978 PVNLPSEPQHTICDDYESNFSVEPPNDPNHLYCNDNMLKNHIITPETSQLYIHKVLNEPIGNGYV 1042

  Fly  1087 WSPPKIAYDIHDQAT-SYDQSEEEMPVTSTAPPGYDLPRPLLDATANGQVLRYEND------LRF 1144
             ...|:|..:...|. |.|.:     :.|.|.|.||  ||...|:...|..:|.|.      |.|
 Worm  1043 -RQDKLARAVSGVANQSLDSA-----LGSPAWPSYD--RPSNKASCLDQTHQYYNTTSKIQYLHF 1099

  Fly  1145 PLN------------IRKSSCTPSY-------------SNMTSEPPATT 1168
            ..:            |.:.|..|:|             .|||...|..|
 Worm  1100 TFDDPDCMTRSRDSAIFEESYHPNYIQSHPLYSKIIIKKNMTPRNPLPT 1148

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	126/304 (41%)
		TyrKc	771..1042	CDD:197581	124/296 (42%)
egl-15	NP_001300356.1	IG_like	41..126	CDD:214653
		Ig	47..126	CDD:299845
		Ig	302..382	CDD:299845
		IG_like	306..384	CDD:214653
		IG_like	401..502	CDD:214653
		Ig3_FGFR	407..503	CDD:143175
		PKc_like	627..933	CDD:304357	130/315 (41%)
		Pkinase_Tyr	640..928	CDD:285015	124/296 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910