Protein Alignment Ret and ver-3

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_509836.1
• Gene: ver-3 / 181289
• WormBaseID: WBGene00006896
• Length: 1227
• Species: Caenorhabditis elegans
• Alignment Length: 1290
• Identity: 278/1290 - (21%)
• Similarity: 466/1290 - (36%)
• Gaps: 371/1290 - (28%)

  Fly     1 MESTTIVFVTLLTIITQRKHCAAVDVYFPTTSVKFNMPINEESESIF----------SKIPLAQF 55
            :..|..|||       .||     .|:.|..||   |.|.::.|.:.          |.|.|...
 Worm   118 LNDTIYVFV-------HRK-----KVFLPLKSV---MIIYKQGEVMVPCKTTKFVDKSDIELYAS 167

  Fly    56 QVLRMEDNRLASDYLYSLEQNPLLRINSSSGEIYMRTDY-RSPNSSATFLVTAFPRDQPDHELLN 119
            .||..|.::...|..|..:....|.......::.....| :..|.:||:::|.......|.
 Worm   168 NVLVKEASKYNYDQRYGFKITKKLYSEKQIVDVNFECRYKKEENQTATYIITEKEASSDDG---- 228

  Fly   120 VSHLSLEVTPQPLEEYCSELEHICFWSSAQYTIAESHGPYRRKDFFEPVLIGALNSRAAKYLCPH 184
             .|.|.|...|              |                                     ||
 Worm   229 -YHFSWEKGFQ--------------W-------------------------------------PH 241

  Fly   185 VSLEYSLNAGSSHFVLKQNRLYTRQTLDHDELNGLNAKAGQLQARITCTVKLSSR---DQ----- 241
            |...:||..         |..|....:.|...|.|:.:..|      |:....|.   |:
 Worm   242 VGYNFSLTC---------NLNYNGSKIFHGYTNKLSIECPQ------CSHDPGSHVHVDRHRIIG 291

  Fly   242 RKFSRILDIKLLDRNDNGPK--LQESSSKFDFYLEQPYFQADEEAGKKVIYVD------KDTLEA 298
            .|.|..:.|:.|:..|:|..  :.|..:|...|.:...:.|.::|..|||...      |:....
 Worm   292 NKISTTVRIQHLELEDSGKYTCIWEHENKETKYTDYHLYVAPKKAQIKVIETSPTIMRIKENRAT 356

  Fly   299 NAHLVYAVHNDSHGLFRPDCHA------YEAD-HTG-RPHTIVSCQLRFSRNGVFRETPYCVSLE 355
            :....:|::.     |..:.:.      |.:. |.| :..||::...|......|.:..:..:|:
 Worm   357 SLTAKFAIYP-----FEKESYTAKWSRIYNSSIHEGPQSETIINDDFRKIAATSFGDGAFSENLD 416

  Fly   356 ARDLTIVSRVDAMSATANVCYHINLSKLH---------ESEQELPQA-LPLRARQHRIFESEEFN 410
            .:...:.:.   ||.|    |.:::|.:.         ..|.:.|.. :.:|........::|:
 Worm   417 IKAFAVSTN---MSGT----YVLSISHMDTVQVVQWEVAIENDEPDVQITVREPSSFFISNQEY- 473

  Fly   411 GDSAGRSLSPPTVDYDKDVSVYRSAASNFRVVQPDSFLDLMRLRSIRFDIVE-DKLGAFGITSTS 474
                          |..|.:::....| ..:...|...:.....|.:|..:| :||.:.|.|...
 Worm   474 --------------YKPDTNLHIECIS-ISIPPADVVFEYKTKNSEQFQEIEPNKLVSVGGTFDR 523

  Fly   475 GIVFVKNPQVLEEAPETIYFLNVTWIDQQRL--SHVRVIN--------VHLVHG---RPENTSCE 526
            |:::                 |||:.:...|  |.:|..|        :.:..|   ||.:   |
 Worm   524 GLIY-----------------NVTFTEGMDLKCSSIRKGNRAITVNKLIKIGEGFEVRPHH---E 568

  Fly   527 LKVKSRSQTCAQIKYQSQCVRY-C--GLATGGGSCQWRGSNSAMFGTRYGSCVP-----ESRYCP 583
            ...|:.....::|.|:...|:. |  .|.:...|..||..||.....   |.:|     |.:...
 Worm   569 KSSKATESEPSKIIYEGDNVKLTCVFPLDSDDWSVSWRFENSKSSDI---SSIPTTTETEIKQYS 630

  Fly   584 DHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCIC----EDNGKCSCAPLDEE 644
            .|:...|.::..                           |.:||..|    ||:.|.....:|.:
 Worm   631 KHLILNLRDVTT---------------------------SFTGTYTCVVKNEDSEKLLETSIDVK 668

  Fly   645 PKMKKPRKRKNETEAEPLLGVRR---------GTPP--------NQPLQ----DPMLLGVLNVAG 688
             .:.||......:.|..::...:         ||||        ..|..    |..:|.|....|
 Worm   669 -AISKPSITGGNSNAVVIVDYDQYFEINCNMTGTPPPVYQWFKDGNPYTHGDVDGSILRVSRARG 732

  Fly   689 -----FEC--------------------DRSCMFF------VITCPLLFVLLLLCLLIAQRKMLQ 722
                 |.|                    .:..:||      ::...::.|.||.|.|.|..::.:
 Worm   733 EDDGEFHCLATNRAGDKLNSIEVQVNNAPKGSLFFYWFLALLLLISIIAVFLLTCKLRASNRLTK 797

  Fly   723 RR---LGKQSMTTSSKQA--LPESGGGDFALMPLQSGFRFESGDAKWEFPREKLQLDTVLGEGEF 782
            ::   |.....|....||  |||    :...:|::....:...:..:|.....|::...:|.|.|
 Worm   798 QKDIALNTLYETMIKHQAGPLPE----EMKDLPVEERTYYLPYNNDYEIDPVNLEILNPIGSGHF 858

  Fly   783 GQVLKGF------ATEIAG---LPGITTVAVKMLKKGSNSVEYMALLS-EFQLLQEV-SHPNVIK 836
            |.|.||.      .::|..   ||    ||||......| ||...::: |.:::..: .:|||:.
 Worm   859 GVVKKGLLGMAYPKSKIESKTRLP----VAVKSSTNPFN-VELQKMMAEELKVMCAIPKNPNVLA 918

  Fly   837 LLGACTSS--EAPLLII-EYARYGSLRSYLRLSRK------IECAGVDFADG-VEPVNVKM---- 887
            |:||.|.:  :..|.|: |:...|:||.:|:..|.      :|...|...|. :.|.:||.
 Worm   919 LIGAVTKNMRQGQLYIVTEFIDGGNLREFLQAHRNTFINELVEDEHVPVDDSYLVPNSVKKKIYK 983

  Fly   888 -----------------------VLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISD 929
                                   :|:...||.||||:|:::..||||||.||||:...||.:|:|
 Worm   984 FDEKLGEGTRLLVEDPDALCTSDLLSIGLQIAKGMAWLADVPCVHRDLACRNVLITKTKIVRIAD 1048

  Fly   930 FGLTRDVYEDDAY-LKRSRDR-VPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGI 992
            |||::.......| .|:|:|. :||:||..|.:.:..:|.||||||||:..:|:.|||.:|||..
 Worm  1049 FGLSKKHTNKTYYRTKKSKDTPLPVRWMPLECIEEFKFTQKSDVWSFGICLYEIFTLGGTPYPNC 1113

  Fly   993 APQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEK-LLGNNAKYIDLE 1056
            ...|:...::.|.|..:||.|.:.:|.:::.||...|..||:|....:.||. :..:::::::
 Worm  1114 DTFNVIEFIRNGNRNKQPEYCHDEIYELMKVCWQFNPKDRPTFNDCITFFENHMRDSSSQFLE-- 1176

  Fly  1057 TNAVSNPLYCGDDSALITTELGEPESLQHLW---SPPKIAYDIHDQATSYDQSEE 1108
              .|.|.|:         ||:.|...|.. |   |.|.:. ::..|.:...|.||
 Worm  1177 --RVENMLH---------TEMQEQSKLDD-WIQDSRPDVP-NVSFQKSPKKQKEE 1218

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	105/329 (32%)
ver-3	NP_509836.1	IG_like	242..>313	CDD:214653	18/85 (21%)
		IG_like	578..667	CDD:214653	22/118 (19%)
		Ig strand B	588..592	CDD:409353	1/3 (33%)
		Ig strand C	602..606	CDD:409353	1/3 (33%)
		Ig strand E	633..637	CDD:409353	0/3 (0%)
		Ig strand F	647..652	CDD:409353	2/4 (50%)
		Ig_3	672..744	CDD:464046	14/71 (20%)
		PTKc	851..1164	CDD:270623	102/317 (32%)