DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ret and abl-1

DIOPT Version :10

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_509778.2 Gene:abl-1 / 181261 WormBaseID:WBGene00000018 Length:1224 Species:Caenorhabditis elegans


Alignment Length:585 Identity:172/585 - (29%)
Similarity:267/585 - (45%) Gaps:126/585 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   710 LLCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMPLQSGFRFESGDAKWEFPREKLQLD 774
            |:|||               |..:||:   :.|.|.|:|.|        :...:||..|.::.:.
 Worm   276 LICLL---------------MYPASKK---DKGRGLFSLSP--------NAPDEWELDRSEIIMH 314

  Fly   775 TVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPNVIKLLG 839
            ..||.|::|.|.:|:...     ...|:|||.||:  :::.....|:|..:::::.|.|:::|||
 Worm   315 NKLGGGQYGDVYEGYWKR-----HDCTIAVKALKE--DAMPLHEFLAEAAIMKDLHHKNLVRLLG 372

  Fly   840 ACTSSEAPLLII-EYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQICKGMAYLS 903
            .|| .|||..|| |:...|:|..|||.:.|         ..:.|:   :::..|.||..||:||.
 Worm   373 VCT-HEAPFYIITEFMCNGNLLEYLRRTDK---------SLLPPI---ILVQMASQIASGMSYLE 424

  Fly   904 ELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSK 968
            ....:||||||||.|:::..|.||:||||.| ..::|.|...:..:.|:||.|||.||.:.::||
 Worm   425 ARHFIHRDLAARNCLVSEHNIVKIADFGLAR-FMKEDTYTAHAGAKFPIKWTAPEGLAFNTFSSK 488

  Fly   969 SDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRP 1033
            ||||:||||.||:.|.|.:||||:...|::.||:.|:|||.|:.|..:||.::..||...|:.||
 Worm   489 SDVWAFGVLLWEIATYGMAPYPGVELSNVYGLLENGFRMDGPQGCPPSVYRLMLQCWNWSPSDRP 553

  Fly  1034 SFKFLASEFEKLLGNNAKYIDLETNAVSNPLYCGDDSALITTEL--------------------- 1077
            .|:.:....|.|:.:|:.     .:.|...|...:|..|.:.:.                     
 Worm   554 RFRDIHFNLENLISSNSL-----NDEVQKQLKKNNDKKLESDKRRSNVRERSDSKSRHSSHHDRD 613

  Fly  1078 GEPESLQHLWSPPKI---AYDIHDQATSYDQSEEEMPVTSTAPPGYDLPRP--------LLDATA 1131
            .:.|||....|.|:|   ::...|.:.|:........|||....|...|.|        ||.:..
 Worm   614 RDRESLHSRNSNPEIPNRSFIRTDDSVSFFNPSTTSKVTSFRAQGPPFPPPPQQNTKPKLLKSVL 678

  Fly  1132 NG-------QVLRYENDLRFPL---NIRKSSCTPSYSNMTSEPPATTSLPHYSVPVKR------- 1179
            |.       :..|.|.|...||   |:||     :.:.:....|....:..|...::|       
 Worm   679 NSNARHASEEFERNEQDDVVPLAEKNVRK-----AVTRLGGTMPKGQRIDAYLDSMRRVDSWKES 738

  Fly  1180 --------GRSYLDMT--NKSL----IPDNLDSREFEK-H--LSKTISFR--FSSLLNLSETKEV 1225
                    |.|.|..|  |.||    :||:::|..:.| |  ..:.:..|  .|.|...|||.|:
 Worm   739 TDADNEGAGSSSLSRTVSNDSLDTLPLPDSMNSSTYVKMHPASGENVFLRQIRSKLKKRSETPEL 803

  Fly  1226  1225
             Worm   804  803

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864 105/279 (38%)
abl-1NP_509778.2 SH3_Abl 119..185 CDD:212784
SH2_ABL 190..283 CDD:198189 5/21 (24%)
PTKc_Abl 304..566 CDD:270645 107/282 (38%)
FABD 1091..1224 CDD:197885
Blue background indicates that the domain is not in the aligned region.

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