Protein Alignment Ret and hir-1

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_504458.1
• Gene: hir-1 / 178936
• WormBaseID: WBGene00016059
• Length: 903
• Species: Caenorhabditis elegans
• Alignment Length: 969
• Identity: 227/969 - (23%)
• Similarity: 365/969 - (37%)
• Gaps: 278/969 - (28%)

  Fly   298 ANAHLVYAVHNDSHGLFR---PDCHAYEADHTGRPHTIVSCQLRFSRNGVFRETPYCVSLEARDL 359
            :|..||    :.:.|.|.   ..|.|:.........::.:|:            |.|..|..::|
 Worm    16 SNQELV----SKAEGCFLRCVAQCVAFVEKSDSTQQSLDACK------------PQCQKLNNKNL 64

  Fly   360 TIVSRVDAMSATANVCYH-INLSKLHESEQELPQALPLRARQ----------------HRIFESE 407
                      .:.|.|:. .|...:.|.....|..|.|:..:                :|...|:
 Worm    65 ----------CSDNTCWSTCNGELVPEKTLPAPTNLTLKGVRGLSWSPVPGAVMYYIGYRTLNSK 119

  Fly   408 EFNGD------SAGRSLSPPT-VDYDKDVSVYRSAAS---------NFRVVQP----DSFLDLMR 452
            .|..|      .....||..| :|...::.|..:|.|         ..::..|    :..|||:.
 Worm   120 TFTSDDFVITEKQTVDLSTLTNIDPCSELEVAVAAFSEDGIGNESKELKISSPKPTANPKLDLLE 184

  Fly   453 LRSIRFDIVEDKLGAFGITSTSGIVF--VKNPQVLEEAPETIYFLNVTWIDQQRLSH-VRVINVH 514
            |:.:...:|.|   .:...:|..:.|  ..:|          :||....:|.|.|.| :..::..
 Worm   185 LQYLNTTLVSD---FYQANATVHVEFRYKTDP----------WFLGPDDLDVQPLFHLISCVDPD 236

  Fly   515 LVHGRP--------ENTSCELKVKS--RSQTCAQIKY-QSQCVRYCGLATGGGSCQWRGSNSAMF 568
            |..|.|        :|::....:.|  ..:.|..:.| ||...:.|...|     :.....|:..
 Worm   237 LSQGIPVPDFDVHVKNSTISTSIGSDMMDRKCRYVYYLQSVMSKKCNTMT-----EMPSPPSSAL 296

  Fly   569 GT--------RYGSCVPESRYCP------------------DHVCDPLEEL------------NP 595
            .|        :...||....|.|                  :::.||...|            |.
 Worm   297 QTIQVECDIVKNAPCVKVPSYQPPLCGMVENVAFSVLSRDRENLNDPASNLTVNVTFIPVTRNNE 361

  Fly   596 MA---------------CPQDCTPAG----RIVGPHSSNENKRGIYSASGTCICED--------- 632
            |.               ..::.|..|    .::|..||...    :.:||.|:.|:
 Worm   362 MPTLYYIGIFGTASEYHTKEEETFLGVNITHVIGKESSCTG----FDSSGNCLAENLNRSIVLQG 422

  Fly   633 ------NGKCSCAPLDEEPKMKKPRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLG----VLNVA 687
                  .|...||..|                      :|..|.|:..|.......    ::.||
 Worm   423 IHPKTLYGLTICAVKD----------------------IRNLTLPDVTLDSKSFRAKADRIMLVA 465

  Fly   688 GFECDRSCMFFVITCPLLFVLLLLCLLI----------AQRKMLQRRLGKQSMTTSSKQALPESG 742
            ....:...|...|....|.|:|:..::|          .:.|....::||.:|....
 Worm   466 HTSNNPVGMIIGIVIGSLVVILVAIVVIWFYFRKKSENMKFKFQMEQVGKNNMNRYI-------- 522

  Fly   743 GGDFALMPLQSGFRFESGDAKWEFPREKLQL--DTVLGEGEFGQVL------KGFATEIAGLP-G 798
              ||.:|..::..        ||..|..|.:  |..||.|.||.|.      |..|.:.|..| |
 Worm   523 --DFPIMAAKNDI--------WEIERRNLIIHNDKKLGSGAFGAVYLGKLIGKSLAHKDANSPLG 577

  Fly   799 IT-------TVAVKMLKKGSNSVEYMALLSEFQLLQEVS-------HPNVIKLLGACTSSEAPLL 849
            |.       .||||||.      ||...:|:.:.|:|::       |..::.:|...|.||...|
 Worm   578 INLMRAENCQVAVKMLP------EYADEMSKHEFLREIALMKTLGYHERLVNMLACVTESEPLCL 636

  Fly   850 IIEYARYGSLRSYLR----LSRKIECAGVDFADGVEP--------VNVKMVLTFAWQICKGMAYL 902
            ::||...|.|..:||    ...|::..|:::.|..|.        |.:|.:|.||.||..|:.||
 Worm   637 VVEYCDNGDLLKFLRERCKYMMKLDDLGINYHDPPENENYDTNMIVTLKQLLQFAVQISYGLEYL 701

  Fly   903 SELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTS 967
            |:...||||:||||||:.:|..|||.||||.|.:|.|.:..|....::|:|||:||::..:.::.
 Worm   702 SQKGFVHRDVAARNVLVHEGTACKIGDFGLCRYIYADQSQYKSKGGKLPLKWMSPEAIRHYEFSI 766

  Fly   968 KSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGR 1032
            |||:||||:|.:|:||||.|||||:.|:::...|:.|.|:::|:||.|..|.::..||..:|:.|
 Worm   767 KSDIWSFGILLFEVITLGGSPYPGMPPEDVLPFLEGGGRIEKPDNCPENFYDVMMQCWNADPDDR 831

  Fly  1033 PSFK----FLASEFEKLLGNNAKYIDLETNAVSNPLYCGD----DSALITTELGEPESL 1083
            ..|.    .||::.|.:. .:..|:.|:.......:..||    |..:|..|:.:|..|
 Worm   832 IEFSDVRMQLATQLEDIT-EDYSYLKLDAAKDYYNVQYGDEKKTDVVIIPDEIIKPSKL 889

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	115/317 (36%)
hir-1	NP_504458.1	fn3	85..164	CDD:394996	14/78 (18%)
		RGP	227..>281	CDD:385243	10/53 (19%)
		PTKc	547..842	CDD:270623	110/300 (37%)