Protein Alignment Ret and F11E6.8

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001255960.1
• Gene: F11E6.8 / 178530
• WormBaseID: WBGene00008711
• Length: 442
• Species: Caenorhabditis elegans
• Alignment Length: 383
• Identity: 122/383 - (31%)
• Similarity: 192/383 - (50%)
• Gaps: 69/383 - (18%)

  Fly   705 LFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESGG-GDFALMPLQSGFRFESGDAKWE--- 765
            ||:::|...|:|  .::|....|.:          .||| |..|:.|..    |.:..::|.
 Worm    55 LFLVVLTVALLA--VLVQYHCQKGT----------NSGGLGAGAISPKS----FSTSPSQWTTCS 103

  Fly   766 ---------------------------FPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVA 803
                                       .|.|.:.|:|::|:|.||.|.:|...:.||  .:..||
 Worm   104 TVSSTYSTQSLLQLIGSDLRQSLQGLLLPSEAVVLETIVGKGYFGNVYRGRMRDPAG--RLIPVA 166

  Fly   804 VKMLK--KGSNSVEYMALLSEFQLLQEVSHPNVIKLLGACTSSEA-PLLIIEYARYGSLRSYLRL 865
            ||.||  :..:.......|.|..:::.:.||:|:.|||...|... |.:::.|...|.|::|:
 Worm   167 VKTLKGERARDIAHIEKFLREGVVMKHLDHPHVLSLLGISISPAGNPWVVLPYMEGGDLKTYI-- 229

  Fly   866 SRKIECAGVDFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDF 930
                       ||....:.|..:|.||.|:.:||:||:....|||||||||.:::..:|.|::||
 Worm   230 -----------ADPNRALCVLELLDFAHQVAQGMSYLAAQHFVHRDLAARNCMISADRIVKVADF 283

  Fly   931 GLTRDVYEDDAYLKRSRD---RVPVKWMAPESLAD-HVYTSKSDVWSFGVLCWELITLGASPYPG 991
            ||..|:.:.::|:..|..   |:|:||:|||||.| .|::|.:||||||||.|||:|..||||..
 Worm   284 GLAVDLLDKESYIDESETGPARLPLKWLAPESLRDRRVFSSATDVWSFGVLMWELLTRAASPYGE 348

  Fly   992 IAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNN 1049
            ::...:...|:||.|:.:|.:|.:.:|.:::.||...|..||.|.||:.....||..|
 Worm   349 VSNTKVRHYLETGMRLPQPTHCPDIIYDLMQCCWRSTPEDRPDFVFLSHRLRALLQEN 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	104/285 (36%)
F11E6.8	NP_001255960.1	PTKc	141..400	CDD:270623	100/273 (37%)