Protein Alignment Ret and Y116A8C.24

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001255917.1
• Gene: Y116A8C.24 / 178481
• WormBaseID: WBGene00013801
• Length: 528
• Species: Caenorhabditis elegans
• Alignment Length: 309
• Identity: 73/309 - (23%)
• Similarity: 140/309 - (45%)
• Gaps: 43/309 - (13%)

  Fly   750 PLQSGFRFESGDAKWEF--PREKLQL---DTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKK 809
            |:.:||..:...:|.::  ..::::.   |.:||.|.|..|.:|   :|.....:..||:|..|.
 Worm   153 PIGAGFFLKRAISKGKYMIAHDRIKYSPKDDLLGTGNFSDVFRG---KIELENQMVNVALKTTKL 214

  Fly   810 GSNSVE----------YMALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLR 864
            ..::::          ...::.|.:::.::.|.||....|........|||||:...|:|:.:|
 Worm   215 LDDTMDPTKNVKANKIKKEMIQEAEVMSQLRHANVTSFFGIAVDRLPILLIIEFCNGGNLQGHL- 278

  Fly   865 LSRKIECAGVDFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISD 929
                     :.|.|.: ..|.:.:  :......|:.|:..:.:.|||:||||.|::.....|:||
 Worm   279 ---------IKFGDRI-GTNERFL--YLHDASAGLNYIHAMSITHRDIAARNCLISVNGFVKLSD 331

  Fly   930 FGL---------TRDVYEDDAYLKRSRDRVPVKWMAPESLAD--HVYTSKSDVWSFGVLCWELIT 983
            ||:         .:.|.|||...:....::||:||:|| |.|  ..::..||:||.|:|.:|:.|
 Worm   332 FGMGLKVRRNESAKKVAEDDDGKENKEPKLPVRWMSPE-LVDTPDAFSKMSDMWSLGILAYEIFT 395

  Fly   984 LGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGR 1032
            ....|:..:...::...:|:|.....|.:....:..:::......|..|
 Worm   396 NATKPFFNLDDTDVMQTVKSGKHPPLPLSMGPDLIRLLKDVLVAAPTQR 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	69/287 (24%)
Y116A8C.24	NP_001255917.1	SH2	70..155	CDD:214585	1/1 (100%)
		PTKc	183..454	CDD:270623	68/279 (24%)