Protein Alignment Ret and kin-26

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_501309.1
• Gene: kin-26 / 177575
• WormBaseID: WBGene00002208
• Length: 433
• Species: Caenorhabditis elegans
• Alignment Length: 327
• Identity: 102/327 - (31%)
• Similarity: 168/327 - (51%)
• Gaps: 36/327 - (11%)

  Fly   721 LQRRLGK-QSMTTSSKQALPESGGGDFALMPLQSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQ 784
            :|:.||. |...|..|:       |...:.|::..|        ||...:::.:...||||.||:
 Worm    94 IQKMLGTYQRNNTEIKE-------GCMLVNPIRRQF--------WELEHDQITIHKKLGEGAFGE 143

  Fly   785 VLKGFATEIAGLPGITTVAVKMLK-KGSNSVEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAPL 848
            |..|......|:..: .||:|.:| ..:...:....|:|.:.::::.|.|:||..|.....|...
 Worm   144 VSSGVMKFKKGMKTV-QVAIKQVKLDKTGKAKIKDFLAEARTMRKLGHQNIIKFYGVGVLQEPLY 207

  Fly   849 LIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLA 913
            |::|.|..|:|.|:|   :|.|...||       ...:|:|..||    |:.|:....::|||:|
 Worm   208 LVMELAVNGALDSFL---KKNEDLSVD-------KKTEMILQAAW----GLEYIHGKPMLHRDIA 258

  Fly   914 ARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLC 978
            |||.|..|||: |||||||||:   ...|..:...:.|::|:|.|::...:.:.|:|||::||||
 Worm   259 ARNCLYTDGKV-KISDFGLTRN---GTVYQIKPNTKSPIRWLAIETIKTMICSEKTDVWAYGVLC 319

  Fly   979 WELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFE 1043
            ||:....|.||||:.|.::.:.:..||||....:....:.:::..|.|:.||.|||...:|...:
 Worm   320 WEIFNNAAEPYPGMKPADVATQVANGYRMPPYPHAQAEIQTMMARCNAENPNDRPSMAEIAEILQ 384

  Fly  1044 KL 1045
            ::
 Worm   385 RV 386

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	91/277 (33%)
kin-26	NP_501309.1	SH2_Fps_family	15..108	CDD:198224	5/13 (38%)
		TyrKc	130..383	CDD:197581	91/271 (34%)