Protein Alignment Ret and W03A5.1

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_498153.3
• Gene: W03A5.1 / 175744
• WormBaseID: WBGene00020966
• Length: 803
• Species: Caenorhabditis elegans
• Alignment Length: 398
• Identity: 109/398 - (27%)
• Similarity: 173/398 - (43%)
• Gaps: 80/398 - (20%)

  Fly   689 FECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMPLQS 753
            |||....:|...|           :...::|..:|...:.:::...|:              |.|
 Worm   419 FECGEKTLFATKT-----------VFDGEKKHHERLKNRLNLSKEEKE--------------LVS 458

  Fly   754 GFRFESG-DAKWE----------------FPREKLQLDT-VLGEGEFGQVLKG-FATEIA-GLPG 798
            .:....| ..|||                ...:|:...| .:|:|.||.|.|| |...:. .:|
 Worm   459 SYMKNQGPQKKWENMPLHETSIRINSLFYVDGKKIDCGTDQIGKGAFGTVKKGKFRNSLGESVP- 522

  Fly   799 ITTVAVKML-KKGSNSVEYMALLSEFQLLQEVSHPNVIKLLG-ACTSSEAPLLIIEYARYGSLRS 861
               ||||.| .:.|:..|.....||.::|:.|:|||::...| :.:..|..|.::......||..
 Worm   523 ---VAVKKLGLRESSKDERNPAFSEMEILEMVAHPNIVFYYGFSISGDEQALYLLFELMDTSLDK 584

  Fly   862 YLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQICKGMAYLSEL--KLVHRDLAARNVLLADGK- 923
            :           :|.:|.:...|.:  |....|||:||::|...  .:||.|||||||||....
 Worm   585 F-----------IDKSDAILSENER--LDILAQICRGMSFLHTRTPSIVHGDLAARNVLLKKHPV 636

  Fly   924 -----ICKISDFGLTRDVYEDDAYLKRSRD---RVPVKWMAPESLADHVYTSKSDVWSFGVLCWE 980
                 ||||:|.||.:...::   |..|.|   ::|.||:.||.|.....:.|:|:|:||::|:|
 Worm   637 YIKKYICKITDLGLAKTCLDE---LYTSYDDPTKIPFKWLPPEVLGSRTLSLKTDIWAFGIVCFE 698

  Fly   981 LITLGASPYPGIAP-QNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEF-E 1043
            :......||....| .||...|..||..::..:.|:.:|:|...|....|..||||..|..:| :
 Worm   699 VCDKVGEPYGACVPTSNLCQYLTDGYVHEKGLHMSDTIYNIALDCMRQHPIERPSFAELVDQFLD 763

  Fly  1044 KLLGNNAK 1051
            .|:.|:.:
 Worm   764 HLIENDGE 771

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	94/296 (32%)
W03A5.1	NP_498153.3	PTKc	498..761	CDD:270623	90/282 (32%)