Protein Alignment Ret and B0252.1

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_495419.2
• Gene: B0252.1 / 174133
• WormBaseID: WBGene00015087
• Length: 809
• Species: Caenorhabditis elegans
• Alignment Length: 746
• Identity: 168/746 - (22%)
• Similarity: 274/746 - (36%)
• Gaps: 228/746 - (30%)

  Fly   423 VDYDKDVSVYRSAASNFRVVQPDSFLDLMRLRSIRFDIVEDKLGAFGITSTSGIVFVKN-----P 482
            :.|..|::....|| .|.|.:.|..::|...|:|                     |.:|     |
 Worm   185 LSYADDLTPLEEAA-EFPVFKSDDEMNLSATRNI---------------------FQENRDFEFP 227

  Fly   483 QVL-EEAPETIYFLNVTWIDQQRLSHVRVINVHLVHGRPENTSCELKVKSRSQTCAQIKYQSQCV 546
            .:: |:.|.:..::.:|..:..:|..|       |.......:|::         :|.|..||.|
 Worm   228 AIIHEDKPSSDVYVFMTSFNVSQLMRV-------VESTINGPTCQM---------SQTKMYSQFV 276

  Fly   547 RYCGLATGGGSCQ----WRGSNSAMFGTRYGSCVPESRYCPDHVCDPLEELNPMACPQDCTPAGR 607
             :..:...|...|    |.|..:..|.:   :|              |:..|.||...:||..
 Worm   277 -HSQIIKNGTVWQIILPWLGQKTHSFSS---NC--------------LKSFNHMAAEPNCTAM-- 321

  Fly   608 IVGPHSSNENKRGIY--------SASGTCIC---EDNGKCSCAP---------------LDEEPK 646
                      |..||        :|:....|   ..|.:|:...               :||:
 Worm   322 ----------KAQIYANFVEHVAAANNQTFCYLFVGNAECATTTNLTTNIKDSTHIRLVMDED-- 374

  Fly   647 MKKPRKRKNETEAE---PL--LGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLL- 705
                   .|:...:   ||  ||....|..||.:.:.|.. :.|.:     .||...:...|||
 Worm   375 -------LNDVYEDFTLPLVNLGFLDKTVDNQVIHNDMFY-LQNYS-----TSCTDEIPMVPLLS 426

  Fly   706 ----------------FVLLLLCLLIA------------QRK-----------MLQRRLGKQSMT 731
                            .:.:.:|..|:            .||           |||.|:.|....
 Worm   427 ARPWHRPKYLSIALDDMLTIFICATISVTTFGILIYRHVSRKHRQQVELLSELMLQPRIYKAPKE 491

  Fly   732 TSSKQALPESGGGDFALMPLQSGFRFESGDAKWEFPREKLQLDT--VLGEGEFGQVLKGFATEIA 794
            .:....||                        ||...|.:.:|.  :||||....|..|   ::.
 Worm   492 CAKVARLP------------------------WEIKSENVHIDKEFLLGEGTISNVYLG---KLK 529

  Fly   795 G----LPGITTVAVKMLKKGSNSVEYMALL---SEFQLLQEVS-------HPNVIKLLGACTSSE 845
            |    :..|..|.:|..:..:.:|...:..   .|.||.:|::       |.::..|||....::
 Worm   530 GKSPIMQWIDRVEMKQYQDCAVAVRVPSHFDEPEEDQLQREIASMRQLRHHDHIALLLGWTNKND 594

  Fly   846 APLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVN---VKMVLTFAWQICKGMAYLSELKL 907
            ....::|.. :.:|..||...|  |.|..|.:.|..|::   .:::....::||.|:.|:....|
 Worm   595 LVCSLLELT-HMNLIKYLSQIR--ETAEQDNSSGFTPMSRIPFQVLYKIIYEICDGIEYIHSRNL 656

  Fly   908 VHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRS--RDRVPVKWMAPESLADHVYTSKSD 970
            |||||.||||||..|...|||.||...:. :|..:...|  ...:||:|:|||..... ::.|||
 Worm   657 VHRDLTARNVLLTTGLRAKISGFGFCSEP-DDPKFAANSLALRYLPVRWLAPECFIGK-FSVKSD 719

  Fly   971 VWSFGVLCWELITLGASPYPG-IAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPS 1034
            .||||||.:|:.:||..||.. |.|:.:...::.|.....|:.||:..|.|:::|:....:.||:
 Worm   720 SWSFGVLMYEMFSLGEQPYEDLIRPEEIIESIRKGRVPAHPKYCSKQTYKIMQSCYQSFMSRRPN 784

  Fly  1035 FKFLASEFEKLLGNNAKYIDLETNAVSNPLY 1065
            |..|         .||.::. .||..:||.:
 Worm   785 FTQL---------KNAFHVQ-STNYYNNPAF 805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	87/300 (29%)
B0252.1	NP_495419.2	Protein Kinases, catalytic domain	515..792	CDD:473864	87/293 (30%)