Protein Alignment Ret and src-1

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001364829.1
• Gene: src-1 / 171722
• WormBaseID: WBGene00005077
• Length: 537
• Species: Caenorhabditis elegans
• Alignment Length: 285
• Identity: 115/285 - (40%)
• Similarity: 160/285 - (56%)
• Gaps: 26/285 - (9%)

  Fly   764 WEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQE 828
            ||.||.:|.|...||:|.||:|..|      ...||..||:|.:|.|:.|.|  |.|.|.|::::
 Worm   259 WEIPRNQLHLKRKLGDGNFGEVWYG------KWRGIVEVAIKTMKPGTMSPE--AFLQEAQIMKQ 315

  Fly   829 VSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAW 893
            ..|||::||...||..|...:|.||...|||..|||            .|| ..:.::.::..|.
 Worm   316 CDHPNLVKLYAVCTREEPFYIITEYMINGSLLQYLR------------TDG-STLGIQALVDMAA 367

  Fly   894 QICKGMAYLSELKLVHRDLAARNVLLADG----KICKISDFGLTRDVYEDDAYLKRSRDRVPVKW 954
            ||..||.||.|.|||||||||||||:.|.    .:.|::||||.|.:.|:|.|..|:..:.|:||
 Worm   368 QIANGMMYLEERKLVHRDLAARNVLVGDKISGVPVVKVADFGLARKLMEEDIYEARTGAKFPIKW 432

  Fly   955 MAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVY- 1018
            .|||:.....:|.||||||:|:|.:|::|.|..||||:..:.:...::.||||..|..|.|.:|
 Worm   433 TAPEAATCGNFTVKSDVWSYGILLYEIMTKGQVPYPGMHNREVVEQVELGYRMPMPRGCPEQIYE 497

  Fly  1019 SIVRTCWADEPNGRPSFKFLASEFE 1043
            .::..||...|:.||:|..|...|:
 Worm   498 EVLLKCWDKTPDRRPTFDTLYHFFD 522

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	111/279 (40%)
src-1	NP_001364829.1	SH3_Src_like	79..130	CDD:212779
		SH2_Src_family	138..240	CDD:199827
		PTKc_Src_like	270..522	CDD:270630	108/272 (40%)