DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ret and Kit

DIOPT Version :9

Sequence 1:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_001116205.1	Gene:	Kit / 16590	MGIID:	96677	Length:	979	Species:	Mus musculus

Alignment Length:	945	Identity:	227/945 - (24%)
Similarity:	364/945 - (38%)	Gaps:	294/945 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 IYVDKDTLEANAHL----VYAVHNDSHGLFRPDCHAYEADHTGRPHTIVSCQLRFSRNGVFRETP 349
            ::.||.||:..|.:    |.:|...||.|.:.|
Mouse   196 LHSDKFTLKVRAAIKAIPVVSVPETSHLLKKGD-------------------------------- 228

  Fly   350 YCVSLEARDLTIVSRVDAMSATANVCYHINLSKLHESEQELPQALPLRARQHRIFESEEFNGD-S 413
                    ..|:|..:..:|.:.|..:    .|::...|.:.|.      :|..:...:||.: .
Mouse   229 --------TFTVVCTIKDVSTSVNSMW----LKMNPQPQHIAQV------KHNSWHRGDFNYERQ 275

  Fly   414 AGRSLSPPTVDYDKDVSVYRSAASNFRVVQPDSFLDLMRLRSIRFDIVEDKLGAFGITSTSGIVF 478
            ...::|...||   |..|:...|:|                         ..|:..:|:|.
Mouse   276 ETLTISSARVD---DSGVFMCYANN-------------------------TFGSANVTTTL---- 308

  Fly   479 VKNPQVLEEAPETIYFLNVTWIDQQRLSHVRVINVHLV-----HGRPE-------NTSCELKVKS 531
                :|:|:.     |:|::.:....:......||.||     :.:||       |.:...|.|.
Mouse   309 ----KVVEKG-----FINISPVKNTTVFVTDGENVDLVVEYEAYPKPEHQQWIYMNRTSANKGKD 364

  Fly   532 --RSQTCAQIKYQSQCVRYCGL-ATGGGSCQWRGSNS-AMFGTRYG------------------- 573
              :|...:.|:|.:| :|...| .|.||:..:..||| |.....:.
Mouse   365 YVKSDNKSNIRYVNQ-LRLTRLKGTEGGTYTFLVSNSDASASVTFNVYVNTKPEILTYDRLINGM 428

  Fly   574 -SCVPESRYCPDHVCD-------------PLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSA 624
             .||.|.  .|:...|             |:..::........:|.|::|           :.|:
Mouse   429 LQCVAEG--FPEPTIDWYFCTGAEQRCTTPVSPVDVQVQNVSVSPFGKLV-----------VQSS 480

  Fly   625 SGTCICEDNGKCSCAPLDEEPKMKK------PRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLGV 683
            ..:.:...||...|...::..|...      ....|.:.:|..|.             .|:|:|.
Mouse   481 IDSSVFRHNGTVECKASNDVGKSSAFFNFAFKGNNKEQIQAHTLF-------------TPLLIGF 532

  Fly   684 LNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFAL 748
            :..||                   .:.:.:::...|.||:     .|.....:.:.|..|.::..
Mouse   533 VVAAG-------------------AMGIIVMVLTYKYLQK-----PMYEVQWKVVEEINGNNYVY 573

  Fly   749 M-PLQSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSN 812
            : |.|..:     |.||||||.:|.....||.|.||:|::..|..:.......||||||||..::
Mouse   574 IDPTQLPY-----DHKWEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKSDAAMTVAVKMLKPSAH 633

  Fly   813 SVEYMALLSEFQLLQEV-SHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSR--------- 867
            ..|..||:||.::|..: :|.|::.||||||.....|:|.||..||.|.::||..|
Mouse   634 LTEREALMSELKVLSYLGNHMNIVNLLGACTVGGPTLVITEYCCYGDLLNFLRRKRDSFIFSKQE 698

  Fly   868 -KIECA------------------------GVDFA---------------------------DGV 880
             :.|.|                        ||.:.                           |..
Mouse   699 EQAEAALYKNLLHSTEPSCDSSNEYMDMKPGVSYVVPTKTDKRRSARIDSYIERDVTPAIMEDDE 763

  Fly   881 EPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKR 945
            ..:::..:|:|::|:.||||:|:....:||||||||:||..|:|.||.||||.||:..|..|:.:
Mouse   764 LALDLDDLLSFSYQVAKGMAFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVK 828

  Fly   946 SRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGI-APQNLWSLLKTGYRMDR 1009
            ...|:|||||||||:...|||.:|||||:|:..|||.:||:|||||: .....:.::|.|:||..
Mouse   829 GNARLPVKWMAPESIFSCVYTFESDVWSYGIFLWELFSLGSSPYPGMPVDSKFYKMIKEGFRMVS 893

  Fly  1010 PENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAVSNPLYCG------- 1067
            ||:....:|.:::|||..:|..||:||.:....||.:.::.|:|      .||...|.
Mouse   894 PEHAPAEMYDVMKTCWDADPLKRPTFKQVVQLIEKQISDSTKHI------YSNLANCNPNPENPV 952

  Fly  1068 --DDSALITTELGEPESLQHLWSPPKIAYDIHDQA 1100
              |.|..:.:......|.|.|.        :|:.|
Mouse   953 VVDHSVRVNSVGSSASSTQPLL--------VHEDA 979

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	121/341 (35%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	119/333 (36%)
Kit	NP_001116205.1	ig	217..308	CDD:278476	24/168 (14%)
		IG_like	221..310	CDD:214653	24/174 (14%)
		Ig4_SCFR	314..414	CDD:143268	24/105 (23%)
		IG_like	325..412	CDD:214653	22/87 (25%)
		Ig	427..501	CDD:299845	13/86 (15%)
		PTKc_Kit	556..930	CDD:270682	132/378 (35%)
		Important for interaction with phosphotyrosine-binding proteins. /evidence=ECO:0000250	571..573		0/1 (0%)
		Pkinase_Tyr	592..926	CDD:285015	119/333 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910