DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ret and Hck

DIOPT Version :10

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_034537.2 Gene:Hck / 15162 MGIID:96052 Length:524 Species:Mus musculus


Alignment Length:376 Identity:127/376 - (33%)
Similarity:191/376 - (50%) Gaps:73/376 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   714 LIAQRKMLQRRLGKQSMTTSSKQAL------PESG------------GGDFALMPLQSGF----- 755
            |:|...||...:.:.|.||....:|      |:.|            .|.|.:.| :|.|     
Mouse   156 LLAPGNMLGSFMIRDSETTKGSYSLSVRDFDPQHGDTVKHYKIRTLDSGGFYISP-RSTFSSLQE 219

  Fly   756 ---RFESG-----------------------DAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIA 794
               .::.|                       || ||.|||.||::..||.|:||:|.      :|
Mouse   220 LVLHYKKGKDGLCQKLSVPCVSPKPQKPWEKDA-WEIPRESLQMEKKLGAGQFGEVW------MA 277

  Fly   795 GLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLIIEYARYGSL 859
            .....|.||||.:|.||.|||  |.|:|..|::.:.|..::| |.|..|.|...::.|:...|||
Mouse   278 TYNKHTKVAVKTMKPGSMSVE--AFLAEANLMKSLQHDKLVK-LHAVVSQEPIFIVTEFMAKGSL 339

  Fly   860 RSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKI 924
            ..:|:..           :|.:....|:: .|:.||.:|||::.:...:||||.|.|:|::...:
Mouse   340 LDFLKSE-----------EGSKQPLPKLI-DFSAQISEGMAFIEQRNYIHRDLRAANILVSASLV 392

  Fly   925 CKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPY 989
            |||:||||.| :.||:.|..|...:.|:||.|||::....:|.||||||||:|..|::|.|..||
Mouse   393 CKIADFGLAR-IIEDNEYTAREGAKFPIKWTAPEAINFGSFTIKSDVWSFGILLMEIVTYGRIPY 456

  Fly   990 PGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLAS 1040
            ||::...:...|:.||||.||:||.|.:|:|:..||.:.|..||:|:::.|
Mouse   457 PGMSNPEVIRALEHGYRMPRPDNCPEELYNIMIRCWKNRPEERPTFEYIQS 507

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864 104/271 (38%)
HckNP_034537.2 SH3 80..135 CDD:473055
SH2_Src_HCK 138..241 CDD:198226 16/85 (19%)
Protein Kinases, catalytic domain 252..522 CDD:473864 110/279 (39%)
Blue background indicates that the domain is not in the aligned region.

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