Protein Alignment Ret and CSK

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_004374.1
• Gene: CSK / 1445
• HGNCID: 2444
• Length: 450
• Species: Homo sapiens
• Alignment Length: 290
• Identity: 107/290 - (36%)
• Similarity: 161/290 - (55%)
• Gaps: 31/290 - (10%)

  Fly   757 FESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLS 821
            :.||   |....::|:|...:|:||||.|:.|   :..|    ..||||.:|   |.....|.|:
Human   184 YRSG---WALNMKELKLLQTIGKGEFGDVMLG---DYRG----NKVAVKCIK---NDATAQAFLA 235

  Fly   822 EFQLLQEVSHPNVIKLLGACTSSEAPLLII-EYARYGSLRSYLRLSRKIECAGVDFADGVEPVNV 885
            |..::.::.|.|:::|||.....:..|.|: ||...|||..||| ||.....|.|
Human   236 EASVMTQLRHSNLVQLLGVIVEEKGGLYIVTEYMAKGSLVDYLR-SRGRSVLGGD---------- 289

  Fly   886 KMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRV 950
             .:|.|:..:|:.|.||.....|||||||||||:::..:.|:||||||:     :|...:...::
Human   290 -CLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTK-----EASSTQDTGKL 348

  Fly   951 PVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSE 1015
            ||||.|||:|.:..:::||||||||:|.||:.:.|..|||.|..:::...::.||:||.|:.|..
Human   349 PVKWTAPEALREKKFSTKSDVWSFGILLWEIYSFGRVPYPRIPLKDVVPRVEKGYKMDAPDGCPP 413

  Fly  1016 AVYSIVRTCWADEPNGRPSFKFLASEFEKL 1045
            |||.:::.||..:...||||..|..:.|.:
Human   414 AVYEVMKNCWHLDAAMRPSFLQLREQLEHI 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	104/277 (38%)
CSK	NP_004374.1	Interaction with PTPN22. /evidence=ECO:0000250|UniProtKB:P41241	9..70
		SH3_CSK	11..67	CDD:212703
		SH2_csk_like	78..175	CDD:198190
		PTKc_Csk	188..443	CDD:133213	105/281 (37%)