Protein Alignment Ret and Fyn

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_030100741.1
• Gene: Fyn / 14360
• MGIID: 95602
• Length: 576
• Species: Mus musculus
• Alignment Length: 297
• Identity: 109/297 - (36%)
• Similarity: 166/297 - (55%)
• Gaps: 27/297 - (9%)

  Fly   749 MPLQSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNS 813
            ||..:....::.|. ||.|||.|||...||.|:||:|..|...      |.|.||:|.||.|:.|
Mouse   289 MPRLTDLSVKTKDV-WEIPRESLQLIKRLGNGQFGEVWMGTWN------GNTKVAIKTLKPGTMS 346

  Fly   814 VEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLII-EYARYGSLRSYLRLSRKIECAGVDFA 877
            .|  :.|.|.|:::::.|..:::|....  ||.|:.|: ||...|||..:|:
Mouse   347 PE--SFLEEAQIMKKLKHDKLVQLYAVV--SEEPIYIVTEYMSKGSLLDFLK------------- 394

  Fly   878 DGV-EPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDA 941
            ||. ..:.:..::..|.|:..||||:..:..:||||.:.|:|:.:|.||||:||||.| :.||:.
Mouse   395 DGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLAR-LIEDNE 458

  Fly   942 YLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYR 1006
            |..|...:.|:||.|||:.....:|.||||||||:|..||:|.|..||||:..:.:...::.|||
Mouse   459 YTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYR 523

  Fly  1007 MDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFE 1043
            |..|::|..:::.::..||..:|..||:|::|....|
Mouse   524 MPCPQDCPISLHELMIHCWKKDPEERPTFEYLQGFLE 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	101/276 (37%)
Fyn	XP_030100741.1	SH3_Fyn_Yrk	124..179	CDD:212939
		SH2_Src_Fyn_isoform_a_like	184..284	CDD:198281
		PTKc_Fyn	300..573	CDD:270655	107/286 (37%)