Protein Alignment Ret and Frk

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_034367.2
• Gene: Frk / 14302
• MGIID: 103265
• Length: 512
• Species: Mus musculus
• Alignment Length: 316
• Identity: 115/316 - (36%)
• Similarity: 170/316 - (53%)
• Gaps: 25/316 - (7%)

  Fly   749 MPLQSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNS 813
            :|......:::.| :||..|..:||...||.|:||:|.:|...      ..|.||||.||.|  |
Mouse   220 VPTPFDLSYKTAD-QWEIDRNSIQLLKRLGSGQFGEVWEGLWN------NTTPVAVKTLKPG--S 275

  Fly   814 VEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFAD 878
            ::....|.|.|:::.:.||.:|:|...||..:...:|.|..|:|||:.||:            .|
Mouse   276 MDPNDFLREAQIMKSLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQ------------ND 328

  Fly   879 GVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTR--DVYEDDA 941
            |...:::...:..|.|:..|||||.....:||||||||||:.:..|.|::||||.|  .|..:|.
Mouse   329 GGSKIHLIQQVDMAAQVASGMAYLESQNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDI 393

  Fly   942 YLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYR 1006
            |..:...::||||.|||::..:.::.||||||||:|.:|:||.|..||.|:....:..:|...||
Mouse   394 YESKHEIKLPVKWTAPEAIRTNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLSQNYR 458

  Fly  1007 MDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAVSN 1062
            :.:|.||.:..|||:..||..||..||:|:.|..:.|.....:..|.|  ||...|
Mouse   459 LPQPSNCPQQFYSIMLECWNVEPKQRPTFETLHWKLEDYFETDCSYSD--TNNFIN 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	105/280 (38%)
Frk	NP_034367.2	SH3_Src_like	54..111	CDD:212779
		SH2_Src_Frk	119..214	CDD:199831
		PTKc_Frk_like	232..501	CDD:270653	109/289 (38%)