DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ret and Flt3

DIOPT Version :9

Sequence 1:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_034359.2	Gene:	Flt3 / 14255	MGIID:	95559	Length:	1000	Species:	Mus musculus

Alignment Length:	1204	Identity:	284/1204 - (23%)
Similarity:	428/1204 - (35%)	Gaps:	417/1204 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 LYSLEQNPLLRINSSSGEIYMRTDYRSPNSSATFLVTAFPRDQPDH--------ELLNVSHLSLE 126
            |.|.|.|     .||:|:   .:.||....|...|..| ||.|.:.        |:.....::|:
Mouse    38 LISHENN-----GSSAGK---PSSYRMVRGSPEDLQCA-PRRQSEGTVYEAATVEVAESGSITLQ 93

  Fly   127 V---TPQPLEEYCSELEHICFWSSAQYTI-AESHGPYRRKDFFEPVLIGALNSRAAKYLCPHVSL 187
            |   ||..|.         |.|.....:: .:.|...:.:......::....::|.:||. |:..
Mouse    94 VQLATPGDLS---------CLWVFKHSSLGCQPHFDLQNRGIVSMAILNVTETQAGEYLL-HIQS 148

  Fly   188 E-------YSLNAGSSH-FVLKQNRLYTRQTLDHDELNGLNAKAGQLQARITCTVKLSSRDQRKF 244
            |       :::|...:. :||:  |.|.|:..:.|.|  |....|..:..:...:..|.|:..|
Mouse   149 EAANYTVLFTVNVRDTQLYVLR--RPYFRKMENQDAL--LCISEGVPEPTVEWVLCSSHRESCK- 208

  Fly   245 SRILDIKLLDRNDNGPKLQESSSKFDFYLEQPYFQADEEAGKKVIYVDKDTLEANAHLVYAVHND 309
                                                  |.|..|:..::..|
Mouse   209 --------------------------------------EEGPAVVRKEEKVL------------- 222

  Fly   310 SHGLFRPDCHAYEADHTGRPHTIVSCQLRFSRNGVFRETPYCVSLEARDLTIVSRVDAMSATANV 374
             |.||..|               :.|   .:||.:.||   |..|...||
Mouse   223 -HELFGTD---------------IRC---CARNALGRE---CTKLFTIDL--------------- 250

  Fly   375 CYHINLSKLHESEQELPQALPLRARQHRIFESEEFNGDSAGRSLSPPTVDYDKDVSVYRSAASNF 439
                         .:.||:
Mouse   251 -------------NQAPQS---------------------------------------------- 256

  Fly   440 RVVQPDSFLDLMRLRSIRFDIVEDKLGAFGITSTSGIVFVKNPQVLEEAPETIYFLNVTWIDQQR 504
              ..|..||.:.....||...:....| ||:|      :....:.|||..   ||...|:...:.
Mouse   257 --TLPQLFLKVGEPLWIRCKAIHVNHG-FGLT------WELEDKALEEGS---YFEMSTYSTNRT 309

  Fly   505 LSHVRVINVHLVHGRPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFG 569
            :..:.:..|..| ||.:         :...||:..|:.||......|.        :|..:|...
Mouse   310 MIRILLAFVSSV-GRND---------TGYYTCSSSKHPSQSALVTILE--------KGFINATSS 356

  Fly   570 TRYGSCVPESRYC--------PDHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIY---- 622
            .......|..::|        |...|..:.......|.|.....|..:.....::||.|.|
Mouse   357 QEEYEIDPYEKFCFSVRFKAYPRIRCTWIFSQASFPCEQRGLEDGYSISKFCDHKNKPGEYIFYA 421

  Fly   623 ------------------------SASGTCICEDNG---------KCS-----CAPLDEEPKMKK 649
                                    :::....|..:|         |||     |.....|....|
Mouse   422 ENDDAQFTKMFTLNIRKKPQVLANASASQASCSSDGYPLPSWTWKKCSDKSPNCTEEIPEGVWNK 486

  Fly   650 PRKRK-----------NETEAEPLLGVR------RGTP-----PNQP-----LQDPMLLGVLNVA 687
            ...||           |.:||...|.|:      .||.     .|.|     :||       |::
Mouse   487 KANRKVFGQWVSSSTLNMSEAGKGLLVKCCAYNSMGTSCETIFLNSPGPFPFIQD-------NIS 544

  Fly   688 GFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMPLQ 752
            .:.....|:.|::.     :::|:|          .:..||....|..|.:..:|       ||.
Mouse   545 FYATIGLCLPFIVV-----LIVLIC----------HKYKKQFRYESQLQMIQVTG-------PLD 587

  Fly   753 S-----GFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSN 812
            :     .||....|.|||||||.|:...|||.|.||:|:...|..|:.......|||||||:.::
Mouse   588 NEYFYVDFRDYEYDLKWEFPRENLEFGKVLGSGAFGRVMNATAYGISKTGVSIQVAVKMLKEKAD 652

  Fly   813 SVEYMALLSEFQLLQEVS-HPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRL----------- 865
            |.|..||:||.:::..:. |.|::.||||||.|....||.||..||.|.:|||.
Mouse   653 SCEKEALMSELKMMTHLGHHDNIVNLLGACTLSGPVYLIFEYCCYGDLLNYLRSKREKFHRTWTE 717

  Fly   866 -----------------------SRKI-------ECAG-----VDFADGVEPVNVKM-------- 887
                                   ||::       :.:|     :...|.:|..|.|.
Mouse   718 IFKEHNFSFYPTFQAHSNSSMPGSREVQLHPPLDQLSGFNGNLIHSEDEIEYENQKRLAEEEEED 782

  Fly   888 --------VLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLK 944
                    :|.||:|:.|||.:|.....|||||||||||:..||:.||.||||.||:..|.:|:.
Mouse   783 LNVLTFEDLLCFAYQVAKGMEFLEFKSCVHRDLAARNVLVTHGKVVKICDFGLARDILSDSSYVV 847

  Fly   945 RSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGI-APQNLWSLLKTGYRMD 1008
            |...|:||||||||||.:.:||.||||||:|:|.||:.:||.:||||| ...|.:.|:::|::|:
Mouse   848 RGNARLPVKWMAPESLFEGIYTIKSDVWSYGILLWEIFSLGVNPYPGIPVDANFYKLIQSGFKME 912

  Fly  1009 RPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLG------NNAKYIDLETNAVSNP-LYC 1066
            :|...:|.:|.::::|||.:...||||..|.|    .||      ..|.|.::..|...:| :|
Mouse   913 QPFYATEGIYFVMQSCWAFDSRKRPSFPNLTS----FLGCQLAEAEEAMYQNMGGNVPEHPSIY- 972

  Fly  1067 GDDSALITTELG-EPESLQHLWSPPKIAYDIHDQ 1099
             .:...::.|.| ||.|       |:....||.:
Mouse   973 -QNRRPLSREAGSEPPS-------PQAQVKIHGE 998

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	129/348 (37%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	127/334 (38%)
Flt3	NP_034359.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..67		7/24 (29%)
		ig	256..346	CDD:278476	24/157 (15%)
		PKc_like	573..950	CDD:304357	144/387 (37%)
		Important for normal regulation of the kinase activity and for maintaining the kinase in an inactive state in the absence of ligand binding. /evidence=ECO:0000250	592..598		2/5 (40%)
		Pkinase_Tyr	611..946	CDD:285015	127/338 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	968..1000		10/40 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910