DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ret and Flt1

DIOPT Version :10

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_034358.2 Gene:Flt1 / 14254 MGIID:95558 Length:1333 Species:Mus musculus


Alignment Length:1456 Identity:323/1456 - (22%)
Similarity:515/1456 - (35%) Gaps:508/1456 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 FVTLLTIIT-QRKHCAAVDV-YFPTTSVKFNMPINEESESIFSKIPLAQFQVLRMEDNRLASDYL 70
            |.:.||:.| |..|...... |.||::.|     .:::||                     |.|:
Mouse    89 FCSTLTLDTAQANHTGLYTCRYLPTSTSK-----KKKAES---------------------SIYI 127

  Fly    71 Y-SLEQNPLLRINSSSGEIYMRTDYR---------SPNSSATFLVTAFPRD--QPDHELLNVSHL 123
            : |...:|.:.:::...::...|:.|         |||.:.|  :..||.|  .||.:.:.    
Mouse   128 FVSDAGSPFIEMHTDIPKLVHMTEGRQLIIPCRVTSPNVTVT--LKKFPFDTLTPDGQRIT---- 186

  Fly   124 SLEVTPQPLEEYCSELEHICFWSSAQ-YTIAESHGPYRRKDFFEPVLIGALNSRAAKYLCPHVSL 187
                                 |.|.: :.||  :..|:.        ||.||..|          
Mouse   187 ---------------------WDSRRGFIIA--NATYKE--------IGLLNCEA---------- 210

  Fly   188 EYSLNAGSSHFVLKQNRLYTRQTLDHDELNGL-----------NAKAGQ-LQARITCTVKLSSRD 240
              ::|          ..||....|.|.:.|.:           ....|| |....|.|.:|::|.
Mouse   211 --TVN----------GHLYQTNYLTHRQTNTILDVQIRPPSPVRLLHGQTLVLNCTATTELNTRV 263

  Fly   241 QRKFS-------RILDIKLLDRNDNGPKLQESSSKFDFYLEQPYFQADEEAGKKVIYVDKDTLEA 298
            |..::       |....:.:||:.:...:..|..|.:          :.|:..|.:|..:     
Mouse   264 QMSWNYPGKATKRASIRQRIDRSHSHNNVFHSVLKIN----------NVESRDKGLYTCR----- 313

  Fly   299 NAHLVYAVHNDSHGLFRPDCHAYE-----ADHTGRP-----------------HTIVSCQLRFSR 341
                  .....|...|....|.||     ..|..:|                 ....|.::.:.:
Mouse   314 ------VKSGSSFQSFNTSVHVYEKGFISVKHRKQPVQETTAGRRSYRLSMKVKAFPSPEIVWLK 372

  Fly   342 NG---VFRETPYCV---SL--------EARDLTIV-----SRVDAMSATANVCYHINLSKLHESE 387
            :|   ..:...|.|   ||        :|.|.||:     ||: ..:.||.:..::......:|.
Mouse   373 DGSPATLKSARYLVHGYSLIIKDVTTEDAGDYTILLGIKQSRL-FKNLTATLIVNVKPQIYEKSV 436

  Fly   388 QELPQ--ALPLRARQHRIFESEEFNGDSAGRSLSPPTV---------DYDKDVSVYRSAASNFRV 441
            ..||.  ..||.:||  :.....:       .:..||:         ::.|:...:.:......:
Mouse   437 SSLPSPPLYPLGSRQ--VLTCTVY-------GIPRPTITWLWHPCHHNHSKERYDFCTENEESFI 492

  Fly   442 VQPDSFLDLMRLRSI--RFDIVEDKLGAFGITSTSGIVFVKNPQV-------------------- 484
            :.|.|.|. .|:.||  |..::|      |...|...:.|.:.|.                    
Mouse   493 LDPSSNLG-NRIESISQRMTVIE------GTNKTVSTLVVADSQTPGIYSCRAFNKIGTVERNIK 550

  Fly   485 -------------LEEAP------------ETIYFLNVTWIDQQRLSHVRVINVHLVH------- 517
                         ||:.|            ....:.::|||      .:|.:|...:|       
Mouse   551 FYVTDVPNGFHVSLEKMPAEGEDLKLSCVVNKFLYRDITWI------LLRTVNNRTMHHSISKQK 609

  Fly   518 -GRPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYGSCVPESRY 581
             ...::.|..|.:..::.:...              :|..:|:.|...:.....|....:.....
Mouse   610 MATTQDYSITLNLVIKNVSLED--------------SGTYACRARNIYTGEDILRKTEVLVRDSE 660

  Fly   582 CPDHVCDPLEEL-------NPMACPQDCTPA----------------GRIVGPHSS-------NE 616
            .| |:...|.:.       ..:.|.....||                |.|:||.:|       .|
Mouse   661 AP-HLLQNLSDYEVSISGSTTLDCQARGVPAPQITWFKNNHKIQQEPGIILGPGNSTLFIERVTE 724

  Fly   617 NKRGIYSASGTCICEDNGKCSCAPLDEEPKMKKPRKRKNETEAEPLLGVRRGTPPNQPLQDPMLL 681
            ...|:|....|                        .:|...|:...|.| :||.....|:     
Mouse   725 EDEGVYRCRAT------------------------NQKGAVESAAYLTV-QGTSDKSNLE----- 759

  Fly   682 GVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDF 746
                           ...:||..:...|...||....:.|:|...:......|....|:.     
Mouse   760 ---------------LITLTCTCVAATLFWLLLTLFIRKLKRSSSEVKTDYLSIIMDPDE----- 804

  Fly   747 ALMPL-QSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKG 810
              :|| :...|.....:||||.||:|:|...||.|.||:|::..|..|...|...||||||||:|
Mouse   805 --VPLDEQCERLPYDASKWEFARERLKLGKSLGRGAFGKVVQASAFGIKKSPTCRTVAVKMLKEG 867

  Fly   811 SNSVEYMALLSEFQLLQEVSHP-NVIKLLGACTSSEAPLL-IIEYARYGSLRSYLRLSRKIECAG 873
            :.:.||.||::|.::|..:.|. ||:.||||||....||: |:||.:||:|.:||:..|.:.|..
Mouse   868 ATASEYKALMTELKILTHIGHHLNVVNLLGACTKQGGPLMVIVEYCKYGNLSNYLKSKRDLFCLN 932

  Fly   874 VDFA----------------------DGV------------------------------EPVNVK 886
            .|.|                      |.|                              :|:.::
Mouse   933 KDAALHMELKKESLEPGLEQGQKPRLDSVSSSSVTSSSFPEDRSVSDVEGDEDYSEISKQPLTME 997

  Fly   887 MVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVP 951
            .::::::|:.:||.:||..|.:||||||||:||::..:.||.||||.||:|::..|::|...|:|
Mouse   998 DLISYSFQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARDIYKNPDYVRRGDTRLP 1062

  Fly   952 VKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGI-APQNLWSLLKTGYRMDRPENCSE 1015
            :|||||||:.|.||::||||||:|||.||:.:||.|||||: ..::..|.||.|.||..||..:.
Mouse  1063 LKWMAPESIFDKVYSTKSDVWSYGVLLWEIFSLGGSPYPGVQMDEDFCSRLKEGMRMRTPEYATP 1127

  Fly  1016 AVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAK-----YIDLETNAV---------SNPLYC 1066
            .:|.|:..||..:|..||.|..|..:...||..|.:     ||.|  ||:         |.|.:.
Mouse  1128 EIYQIMLDCWHKDPKERPRFAELVEKLGDLLQANVQQDGKDYIPL--NAILTRNSGFTYSTPTFS 1190

  Fly  1067 GD------------------------------------------------DSALIT-TELGEPES 1082
            .|                                                |..|.| |.||.|..
Mouse  1191 EDLFKDGFADPHFHSGSSDDVRYVNAFKFMSLERIKTFEELSPNSTSMFEDYQLDTSTLLGSPLL 1255

  Fly  1083 LQHLW--SPPKIAYDIHDQATSYDQSEEEMPVTSTAPPGYDLPRPLLDATANGQVLRYENDLRFP 1145
            .:..|  :.||.:..|..:..|   ..:|..::       |||||....::.|.:...::|   .
Mouse  1256 KRFTWTETKPKASMKIDLRIAS---KSKEAGLS-------DLPRPSFCFSSCGHIRPVQDD---E 1307

  Fly  1146 LNIRKSSC---TPSYSNMT--SEPPA 1166
            ..:.|.||   .|.|:::.  |.|||
Mouse  1308 SELGKESCCSPPPDYNSVVLYSSPPA 1333

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864 128/333 (38%)
Flt1NP_034358.2 Ig_3 32..109 CDD:464046 6/19 (32%)
IG_like 144..220 CDD:214653 24/134 (18%)
Ig 232..331 CDD:472250 19/119 (16%)
Ig strand B 249..253 CDD:409448 1/3 (33%)
Ig strand C 264..268 CDD:409448 1/3 (33%)
Ig strand E 295..299 CDD:409448 1/3 (33%)
Ig strand F 309..314 CDD:409448 1/15 (7%)
Ig strand G 322..325 CDD:409448 1/2 (50%)
Ig 334..425 CDD:472250 16/91 (18%)
Ig strand B 354..358 CDD:409353 0/3 (0%)
Ig strand C 367..371 CDD:409353 0/3 (0%)
Ig strand E 389..393 CDD:409353 2/3 (67%)
Ig strand F 403..408 CDD:409353 3/4 (75%)
Ig strand G 418..421 CDD:409353 0/2 (0%)
Ig 447..553 CDD:472250 18/121 (15%)
Ig strand B 451..455 CDD:409353 1/5 (20%)
Ig strand C 464..468 CDD:409353 1/3 (33%)
Ig strand E 515..520 CDD:409353 1/4 (25%)
Ig strand F 533..538 CDD:409353 0/4 (0%)
Ig strand G 546..549 CDD:409353 0/2 (0%)
IG_like 570..641 CDD:214653 10/90 (11%)
Ig strand B 574..578 CDD:409353 0/3 (0%)
Ig strand C 587..595 CDD:409353 3/13 (23%)
Ig strand E 620..624 CDD:409353 1/3 (33%)
Ig strand F 634..639 CDD:409353 1/4 (25%)
I-set 662..749 CDD:400151 18/111 (16%)
Ig strand B 680..683 CDD:409353 0/2 (0%)
Ig strand C 692..696 CDD:409353 0/3 (0%)
Ig strand E 715..719 CDD:409353 1/3 (33%)
Ig strand F 729..734 CDD:409353 1/4 (25%)
Protein Kinases, catalytic domain 820..1157 CDD:473864 132/336 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 947..983 2/35 (6%)

Return to query results.
Submit another query.