DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ret and Fgfr3

DIOPT Version :9

Sequence 1:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_001156689.1	Gene:	Fgfr3 / 14184	MGIID:	95524	Length:	802	Species:	Mus musculus

Alignment Length:	440	Identity:	167/440 - (37%)
Similarity:	240/440 - (54%)	Gaps:	67/440 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   696 MFFVITCPLLFVLLLLCLLIAQ-RKMLQRRLG-----KQSMTTSSKQALPESGGGDFALMPLQSG 754
            :||      ||:|::..:::.: |...::.||     |.|.....:|...||.....:..||...
Mouse   378 VFF------LFILVVAAVILCRLRSPPKKGLGSPTVHKVSRFPLKRQVSLESNSSMNSNTPLVRI 436

  Fly   755 FRFESG---------------DAKWEFPREKLQLDTVLGEGEFGQVLK----GFATEIAGLPGIT 800
            .|..||               |.|||..|.:|.|...||||.||||:.    |...:....|  .
Mouse   437 ARLSSGEGPVLANVSELELPADPKWELSRTRLTLGKPLGEGCFGQVVMAEAIGIDKDRTAKP--V 499

  Fly   801 TVAVKMLKKGSNSVEYMALLSEFQLLQEV-SHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLR 864
            ||||||||..:...:...|:||.::::.: .|.|:|.||||||......:::|||..|:||.:||
Mouse   500 TVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYVLVEYAAKGNLREFLR 564

  Fly   865 LSRKIECAGVDFADGV-----EPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKI 924
            ..|.   .|:|::...     |.:..|.:::.|:|:.:||.||:..|.:||||||||||:.:..:
Mouse   565 ARRP---PGMDYSFDACRLPEEQLTCKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTEDNV 626

  Fly   925 CKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPY 989
            .||:||||.|||:..|.|.|.:..|:||||||||:|.|.|||.:|||||||||.||:.|||.|||
Mouse   627 MKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLLWEIFTLGGSPY 691

  Fly   990 PGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLL--GNNAKY 1052
            |||..:.|:.|||.|:|||:|.:|:..:|.|:|.||...|:.||:||.|..:.:::|  .:..:|
Mouse   692 PGIPVEELFKLLKEGHRMDKPASCTHDLYMIMRECWHAVPSQRPTFKQLVEDLDRILTVTSTDEY 756

  Fly  1053 IDL------------ETNAVSNPLYCGDDSALITTELGEPESLQHLWSPP 1090
            :||            :|.:.|:   .|||| :.|.:|..|       .||
Mouse   757 LDLSVPFEQYSPGGQDTPSSSS---SGDDS-VFTHDLLPP-------GPP 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	130/290 (45%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	129/280 (46%)
Fgfr3	NP_001156689.1	IGc2	51..110	CDD:197706
		IG	52..108	CDD:214652
		Ig2_FGFR	155..239	CDD:143265
		IG_like	254..349	CDD:214653
		Ig3_FGFR	262..350	CDD:143175
		PTKc_FGFR3	455..788	CDD:173652	145/341 (43%)
		Pkinase_Tyr	468..744	CDD:285015	129/280 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910