Protein Alignment Ret and Fes

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_034324.2
• Gene: Fes / 14159
• MGIID: 95514
• Length: 822
• Species: Mus musculus
• Alignment Length: 977
• Identity: 236/977 - (24%)
• Similarity: 359/977 - (36%)
• Gaps: 267/977 - (27%)

  Fly   134 EYCSELEHICF-------WSSAQYTIAESHGPYRRKDFFEPVL-----IGALNSRAAKYLCPHVS 186
            ||...|.|:..       |||         ||      ..||.     |.:.....::.|..|..
Mouse    43 EYAGLLHHMSLQDSGGQSWSS---------GP------DSPVSQSWAEITSQTENLSRVLRQHAE 92

  Fly   187 LEYSLNAG--SSHFVLKQNRLYTRQTLDHDELNGLNAKAGQLQARITCTVKLSSRDQRKFSRILD 249
               .||:|  |...||.:.|.:.|:|        .|.:..|||..:|   |..|:|..|......
Mouse    93 ---DLNSGPLSKLSVLIRERQHLRKT--------YNEQWQQLQQELT---KTHSQDIEKLKTQYR 143

  Fly   250 IKLLDRNDNGPKLQESSSKFDFYLEQPYFQADEEAGKKVIYVDKDTLEANAHLVYAVHND-SHGL 313
            ..:.|......|.||:|.             |::..|.     ||....:...::|.||. ..|:
Mouse   144 TLVRDSTQARRKYQEASK-------------DKDRDKA-----KDKYVRSLWKLFAHHNRYVLGV 190

  Fly   314 FRPDCHAYEADHTGRPHTIVSCQ-LRFSRNGVFRETPYCVSLEARDLTIVSRVDAMSATANVCYH 377
            .....|.:.......|..:.|.| |.....|:.::    :..|..:::.:.:.|..|
Mouse   191 RAAQLHHHHHHRFMLPGLLQSLQDLHEEMAGILKD----ILQEYLEISSLVQDDVAS-------- 243

  Fly   378 INLSKLHESEQELPQALPLRARQHRIFESEEFNGDSAGRSLSPPTVDYDKDVSVYRSAASNFRVV 442
                 :|   :||..|   .||....||...|..........||.|.:|:      |...:...:
Mouse   244 -----IH---RELAAA---AARIQPEFEYLGFLRQYGSTPDVPPCVTFDE------SLLEDGEQL 291

  Fly   443 QPDSFLDLMRLRSIRFDIVEDKLGAFGITSTSGIVFVKNPQVLEEAPETIYFLNVTWIDQQRLSH 507
            :|..    ::|..:..:.|:..|     ||.:..:.|...:||..              |:.:|.
Mouse   292 EPGE----LQLNELTLESVQHTL-----TSVTDELAVATKEVLSR--------------QEMVSQ 333

  Fly   508 VRVINVHLVHGRPENTSCELKVKSRSQ--------------TCAQIKYQSQCVRYCGLATGGGSC 558
            ::    ..:....:||....:|:..|:              .|:|.|.|:|             .
Mouse   334 LQ----RELQSEEQNTHPRERVQLLSKRQMLQEAIQGLQIALCSQDKLQAQ-------------Q 381

  Fly   559 QWRGSNSAMFGTRYGSCVP---ESRYCPDHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRG 620
            :...|.....||.....||   :.|:.........|        ...||...|:..|.|     |
Mouse   382 ELLQSKMEQLGTGEPPAVPLLQDDRHSTSSTEQERE--------GGRTPTLEILKSHFS-----G 433

  Fly   621 IYSASGTCICEDNGKCSC-APLDEEPKMKKP--------------------------RKRKNETE 658
            |:          ..|.|. .||...|:::||                          ..|:::.:
Mouse   434 IF----------RPKFSIPPPLQLVPEVQKPLYEQLWYHGAIPRAEVAELLTHSGDFLVRESQGK 488

  Fly   659 AEPLLGVR-RGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQ 722
            .|.:|.|. .|.|.:..:|....|..|...||.          :.|||...||
Mouse   489 QEYVLSVMWDGQPRHFIIQSSDNLYRLEGDGFP----------SIPLLITHLL------------ 531

  Fly   723 RRLGKQSMTTSSKQALPESGGGDFALMPLQSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLK 787
                      ||:|.|.:..|...        ||....| ||....|.|.|...:|.|.||:|..
Mouse   532 ----------SSQQPLTKKSGVVL--------FRAVPKD-KWVLKHEDLVLGEQIGRGNFGEVFS 577

  Fly   788 GFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLIIE 852
            |...     ...|.||||..::..........|.|.::|::.:|||:::|:|.||..:...:::|
Mouse   578 GRLR-----ADNTPVAVKSCRETLPPDLKAKFLQEARILKQYNHPNIVRLIGVCTQKQPIYIVME 637

  Fly   853 YARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNV 917
            ..:.|...::||            .:|.. :.||.:|........||.||.....:||||||||.
Mouse   638 LVQGGDFLTFLR------------TEGAR-LRVKTLLQMVGDAAAGMEYLESKCCIHRDLAARNC 689

  Fly   918 LLADGKICKISDFGLTRD----VYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLC 978
            |:.:..:.||||||::|:    :|...|.|:    :|||||.|||:|....|:|:|||||||:|.
Mouse   690 LVTEKNVLKISDFGMSREEADGIYAASAGLR----QVPVKWTAPEALNYGRYSSESDVWSFGILL 750

  Fly   979 WELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFE 1043
            ||..:|||||||.:..|.....::.|:|:..||.|.:||:.::..|||.||..||||..:..|..
Mouse   751 WETFSLGASPYPNLTNQQTREFVEKGHRLPCPELCPDAVFRLMEQCWAYEPGQRPSFSIICQELH 815

  Fly  1044 KL 1045
            .:
Mouse   816 SI 817

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	100/280 (36%)
Fes	NP_034324.2	Important for interaction with membranes containing phosphoinositides. /evidence=ECO:0000250	1..300		70/336 (21%)
		F-BAR_Fes	7..239	CDD:153369	52/246 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	392..420		6/35 (17%)
		SH2_Fps_family	453..537	CDD:198224	21/115 (18%)
		Protein Kinases, catalytic domain	564..814	CDD:473864	97/271 (36%)