Protein Alignment Ret and Fer

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001033086.2
• Gene: Fer / 14158
• MGIID: 105917
• Length: 823
• Species: Mus musculus
• Alignment Length: 995
• Identity: 220/995 - (22%)
• Similarity: 366/995 - (36%)
• Gaps: 306/995 - (30%)

  Fly   133 EEYCSELEHICFWSSAQYTIAESHGPYRRKDFFEPVLIGALNSRAAKYLCPHVSLEYSLNAGSSH 197
            :||...|:::|.....:.|:..::.....|.:   :|:.....:.::.:..|..   .||:|..|
Mouse    40 KEYAYTLQNLCNQVDKESTVQVNYVSNVSKSW---LLMIQQTEQLSRIMKTHAE---DLNSGPLH 98

  Fly   198 FVLKQNRLYTRQTLDHDELN----GLNAKAGQLQARITCTVKLSSRDQRKFSRILDIKLLDRNDN 258
                  || |....|..::.    |::.   |::|.:   :|::..:..|........:.:.|..
Mouse    99 ------RL-TMMIKDKQQVKKSYVGIHQ---QIEAEM---IKVTKTELEKLKSSYRQLIKEMNSA 150

  Fly   259 GPKLQESSSKFDFYLEQPYFQADEEAGKKVIYVDKDTLEANAHLVYAVHND-SHGLFRPDCHAYE 322
            ..|.:|:.:|            .:|..|.....||.|::     ::.:||. ...|.....|..:
Mouse   151 KEKYKEALAK------------GKETEKAKERYDKATMK-----LHMLHNQYVLALKGAQLHQSQ 198

  Fly   323 ADHTGRPHTIVSCQ-----LRFSRNGVFRETPYCVSLEARDLTIVSRVDAMSATANVCYHINLSK 382
            ...|..|..:.|.|     :..:..|:|.:.....||...::..|.:...||.
Mouse   199 YYDTTLPLLLDSVQKMQEEMIKALKGIFDDYSQITSLVTEEIVNVHKEIQMSV------------ 251

  Fly   383 LHESEQELPQALPLRARQHRIFESEEFNGDSAGRSLSPPTVDYDKDVSVYRSAASNFRVVQPDSF 447
                                    |:.:          |:.:|:..:.|:|:.|:..:.::.|:.
Mouse   252 ------------------------EQID----------PSTEYNNFIDVHRTTAAKEQEIEFDTS 282

  Fly   448 L----DLMRLRSIRFDIVEDKLGAFGITSTSGIVFVKNPQVLEEAPETIYFLNVTWIDQQRLSHV 508
            |    :.::...|.::         .:|:.|..|.:|.  :.||..:|          ||.|.|.
Mouse   283 LLEENENLQANEIMWN---------NLTADSLQVMLKT--LAEELTQT----------QQMLLHK 326

  Fly   509 RVINVHLVHGRPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYG 573
            ....:.|          |.:::...:||.:   :|..|...|..
Mouse   327 EAAVLEL----------EKRIEESFETCEK---KSDIVLLLGQK--------------------- 357

  Fly   574 SCVPESRYCPDHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSC 638
                          ..||||........||.| :.....:..|.|          :.|::||
Mouse   358 --------------QALEELKQSVQQLRCTEA-KCAAQKALLEQK----------VQENDGK--- 394

  Fly   639 APLDEEPKM--------------KKPRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLGVLNVAGF 689
                |.|.:              :|.|..|.|:....:.|:         ::.|.  .||..:..
Mouse   395 ----EPPPVVNYEEDARSVTSMERKERLSKFESIRHSIAGI---------IKSPK--SVLGSSTQ 444

  Fly   690 ECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQR--------RLGKQSMTTSSKQAL-PESGG-- 743
            .||      ||:             :.:|.:.:.        |:..|.:.......| .||.|
Mouse   445 VCD------VIS-------------VGERPLAEHDWYHGAIPRIEAQELLKQQGDFLVRESHGKP 490

  Fly   744 GDFALMPLQSG-------------FRFE------------------------SG---------DA 762
            |::.|.....|             :|||                        ||         |.
Mouse   491 GEYVLSVYSDGQRRHFIIQFVDNLYRFEGTGFSNIPQLIDHHFNTKQVITKKSGVVLLNPIPKDK 555

  Fly   763 KWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQ 827
            ||....|.:.|..:||:|.||:|.||      .|...|.||:|..|:.......:..|.|.::|:
Mouse   556 KWVLNHEDVSLGELLGKGNFGEVYKG------TLKDKTPVAIKTCKEDLPQELKIKFLQEAKILK 614

  Fly   828 EVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFA 892
            :..|||::||:|.||..:...:|:|....|...::|| .||.|            :.:|.::.|:
Mouse   615 QYDHPNIVKLIGVCTQRQPVYIIMELVPGGDFLTFLR-KRKDE------------LKLKQLVRFS 666

  Fly   893 WQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYED-DAYLKRSRDRVPVKWMA 956
            ..:..||.||.....:||||||||.|:.:....||||||::|.  || ..|......::|:||.|
Mouse   667 LDVAAGMLYLESKNCIHRDLAARNCLVGENNTLKISDFGMSRQ--EDGGVYSSSGLKQIPIKWTA 729

  Fly   957 PESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIV 1021
            ||:|....|:|:|||||||:|.||..:||..||||:..|.....::.||||..|:||.|.|::|:
Mouse   730 PEALNYGRYSSESDVWSFGILLWETFSLGVCPYPGMTNQQAREQVERGYRMSAPQNCPEEVFTIM 794

  Fly  1022 RTCWADEPNGRPSFKFLASE 1041
            ..||..:|..||.|..|..|
Mouse   795 MKCWDYKPENRPKFNDLHKE 814

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	103/273 (38%)
Fer	NP_001033086.2	Important for interaction with membranes containing phosphoinositides. /evidence=ECO:0000250	1..300		54/350 (15%)
		F-BAR_Fer	5..238	CDD:153370	42/233 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	389..408		5/25 (20%)
		SH2_Fps_family	454..539	CDD:198224	13/84 (15%)
		Protein Kinases, catalytic domain	567..817	CDD:473864	102/269 (38%)