DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ret and Csf1r

DIOPT Version :9

Sequence 1:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_001032948.2	Gene:	Csf1r / 12978	MGIID:	1339758	Length:	977	Species:	Mus musculus

Alignment Length:	941	Identity:	241/941 - (25%)
Similarity:	373/941 - (39%)	Gaps:	294/941 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   327 GRPHTIVSCQLRFSRNGVFRETPYCVSLEARDLTIV----SRVDAMSATANVCYHINLSKLHESE 387
            ||..|.....|:.:|  |..|.|. :.||...|..:    :::...:..|.|.:::.| |..:::
Mouse   183 GRESTSTGIWLKVNR--VHPEPPQ-IKLEPSKLVRIRGEAAQIVCSATNAEVGFNVIL-KRGDTK 243

  Fly   388 QELPQALPLRARQHRIFESEEFNGD------SAGRSLSPPTVDYDKDVSVY----------RSAA 436
            .|:|                 .|.|      ...|:||...||: :|..:|          |:|.
Mouse   244 LEIP-----------------LNSDFQDNYYKKVRALSLNAVDF-QDAGIYSCVASNDVGTRTAT 290

  Fly   437 SNFRVVQPDSFLDLMRLRSIRFDI-VEDKLGAFGITSTSGIVFVKNPQVLEEAPETIYFLNVTWI 500
            .||:||: .::|:|...:|:..:: |.|.|          |:.|.     .:|..:|...|.|::
Mouse   291 MNFQVVE-SAYLNLTSEQSLLQEVSVGDSL----------ILTVH-----ADAYPSIQHYNWTYL 339

  Fly   501 -----DQQRLSHV--RVI---NVHLVHGRPE------------------NTSCELKVKSRSQTCA 537
                 ||::|..:  |.|   ...|...|.:                  |.:.||
Mouse   340 GPFFEDQRKLEFITQRAIYRYTFKLFLNRVKASEAGQYFLMAQNKAGWNNLTFEL---------- 394

  Fly   538 QIKYQSQCVRYCGLATGGGSCQWRGSNSA--MFGTRYGSCVPESRY--CPDHV--CDPLEEL--- 593
            .::|..:.           |..|...|.:  :|....|...|...:  |..|.  ||..:.|
Mouse   395 TLRYPPEV-----------SVTWMPVNGSDVLFCDVSGYPQPSVTWMECRGHTDRCDEAQALQVW 448

  Fly   594 ---NPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSCAPLDEEPKMKKPRKRKN 655
               :|....|  .|..:::   ..::...|....:.|..|:.:....
Mouse   449 NDTHPEVLSQ--KPFDKVI---IQSQLPIGTLKHNMTYFCKTHNSVG------------------ 490

  Fly   656 ETEAEPLLGVRRGTP---PNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQ 717
             ..::....|..|..   |::.|..|:::..::|..                |.|||||.||...
Mouse   491 -NSSQYFRAVSLGQSKQLPDESLFTPVVVACMSVMS----------------LLVLLLLLLLYKY 538

  Fly   718 R---------KMLQRRLGKQSMTTSSKQALPESGGGDFALMPLQSGFRFESGDAKWEFPREKLQL 773
            :         |:::|..| .|.|......||.                    :.||||||..||.
Mouse   539 KQKPKYQVRWKIIERYEG-NSYTFIDPTQLPY--------------------NEKWEFPRNNLQF 582

  Fly   774 DTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEV-SHPNVIKL 837
            ...||.|.||:|::..|..:.....:..|||||||..:::.|..||:||.:::..: .|.|::.|
Mouse   583 GKTLGAGAFGKVVEATAFGLGKEDAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNL 647

  Fly   838 LGACTSSEAPLLIIEYARYGSLRSYLRLSRKIEC------------------------------- 871
            |||||.....|:|.||..||.|.::||  ||.|.
Mouse   648 LGACTHGGPVLVITEYCCYGDLLNFLR--RKAEAMLGPSLSPGQDSEGDSSYKNIHLEKKYVRRD 710

  Fly   872 -----AGVDFADGVEPVNVKM---------------------VLTFAWQICKGMAYLSELKLVHR 910
                 .|||....:.||:...                     :|.|:.|:.:|||:|:....:||
Mouse   711 SGFSSQGVDTYVEMRPVSTSSSDSFFKQDLDKEASRPLELWDLLHFSSQVAQGMAFLASKNCIHR 775

  Fly   911 DLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFG 975
            |:|||||||..|.:.||.||||.||:..|..|:.:...|:|||||||||:.|.|||.:|||||:|
Mouse   776 DVAARNVLLTSGHVAKIGDFGLARDIMNDSNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYG 840

  Fly   976 VLCWELITLGASPYPGIAPQN-LWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFK--- 1036
            :|.||:.:||.:|||||...| .:.|:|.||:|.:|....:.:|||:::||..||..||:|:
Mouse   841 ILLWEIFSLGLNPYPGILVNNKFYKLVKDGYQMAQPVFAPKNIYSIMQSCWDLEPTRRPTFQQIC 905

  Fly  1037 FLASEFEKLLGNNAKYIDLETNAVSNPLYCGDD-----SALITTELGEPESLQHLWSPPKIAYDI 1096
            ||..|..:|...:..|.:|.::..|:    |.|     |...::|..|..|.:||
Mouse   906 FLLQEQARLERRDQDYANLPSSGGSS----GSDSGGGSSGGSSSEPEEESSSEHL---------- 956

  Fly  1097 HDQATSYDQSEEEMPVTSTAPPGYDLPRPLL 1127
                             :...|| |:.:|||
Mouse   957 -----------------ACCEPG-DIAQPLL 969

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	125/340 (37%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	123/332 (37%)
Csf1r	NP_001032948.2	ig	25..85	CDD:278476
		IG_like	28..101	CDD:214653
		IG_like	113..195	CDD:214653	4/11 (36%)
		Ig	113..179	CDD:299845
		ig	207..293	CDD:278476	20/104 (19%)
		IG_like	209..295	CDD:214653	20/104 (19%)
		Ig4_SCFR_like	299..398	CDD:143176	22/123 (18%)
		IG_like	311..395	CDD:214653	19/108 (18%)
		Regulatory juxtamembrane domain. /evidence=ECO:0000250	540..572		7/52 (13%)
		PTKc_CSF-1R	541..913	CDD:133237	137/394 (35%)
		Pkinase_Tyr	580..904	CDD:285015	121/325 (37%)
		Activation loop. /evidence=ECO:0000250	794..816		9/21 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	921..957		11/66 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910