Protein Alignment Ret and LOC1279581

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_061512028.1
• Gene: LOC1279581 / 1279581
• VectorBaseID: AGAMI1_009797
• Length: 872
• Species: Anopheles gambiae
• Alignment Length: 982
• Identity: 218/982 - (22%)
• Similarity: 351/982 - (35%)
• Gaps: 357/982 - (36%)

  Fly   278 FQADEEAGKKVIYVDKDTLEANAHLVYAVHNDSHGLFRPDCHAYEADHTGRPHTIVSCQLRFSRN 342
            |::|:.. |..::.:....|...::|...|.||.     .|...::......|  :.|
Mosquito    37 FRSDQHV-KLHVWWNSTLPETTDYVVTITHIDSE-----KCMLKDSPFENHKH--IKC------- 86

  Fly   343 GVFRETPYCVSLEARDLTIVSRVDAMSATANVCYHINLSKLHESEQELPQALPLRARQHRIFESE 407
                 .|..||.|..::||.|  |......:.|                   |:  :||..:..:
Mosquito    87 -----APIVVSAETTEVTIPS--DLNGVFKHTC-------------------PI--QQHCTYSIQ 123

  Fly   408 EFNGDSAGRSLSPPTVDYDKDVSVYRSAASNFRVVQPDSFLDLMRLRSIRFDIVE--------DK 464
            .       .:|:.||                 ||.      |::.:.    |.||        :.
Mosquito   124 V-------ETLNLPT-----------------RVT------DVIEVP----DCVEGLCSCHYAEH 154

  Fly   465 LGAFGITSTSGIVFVKNPQVLEEAPETIYFLNVTWIDQQRLSHVRVINVHLVHGRPENTSCELKV 529
            |.|  :.:||.|:.:...|::           |:|          .:........|||.:.:
Mosquito   155 LPA--LLNTSAIIKITTNQLI-----------VSW----------TLGTFNKTEMPENVNLK--- 193

  Fly   530 KSRSQTCAQIKYQSQCVRYCGLATG-GGSCQWRGSNSAM-------------------FGTRYGS 574
                            ..|.|:..| .....|.|.:|:|                   .|::|..
Mosquito   194 ----------------AIYLGVRRGTNNDLAWGGQHSSMREIMLPVESNTHSFNINDFIGSKYIF 242

  Fly   575 CVPESRYCPDHVCDPLEELNPMACPQDCTPAGRIVG-PHSSNENKRGIYSASGTCICEDNGKCSC 638
            .|            .|:.::...|.:...|.  :|. |.:..........:.||  |.::..|:|
Mosquito   243 VV------------QLKVIDTRDCERTAQPI--LVSLPDAEKRLPNATGGSKGT--CTNDTVCNC 291

  Fly   639 APLDEEPKMKKPRKRKNETEAEPLLGVR----------RGTPP---NQP-------LQ------- 676
            ..|:..|..              |||.|          |...|   .||       ||
Mosquito   292 ERLNRFPDF--------------LLGCRHEGSEIIVTWRTLKPVTWRQPSSTDIVQLQLAIRSEL 342

  Fly   677 ----------DPMLLGVLNVAGFECDR----SCMFFVITCPLL---------------------- 705
                      |||   ..|...|..|.    |...||:|...:
Mosquito   343 TGAILCSVSVDPM---ATNTHTFFVDEIVPTSSTSFVLTASFIDGNNYCERIIPTYKIPPNLTST 404

  Fly   706 -FVLLLLCLLIAQRKM----------LQRRLGKQSMTTSSKQALPESGGGDFALMPLQSGFRF-- 757
             .::.::|:|:|...:          .:||...:....:.:.....|.|.....:.::....:
Mosquito   405 SILVPVICVLVAVITVTVLASILFIYYKRRTKFRWKANNWRGVYVRSSGDHHPQVAMEENRLYID 469

  Fly   758 -------ESGDAKW-EFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSV 814
                   ..|||.: |.|...|::...:|:|.||:|....|.::.|..|...||:|.|||.|:|.
Mosquito   470 MDILNARARGDADYLEVPHSCLRIGREIGKGAFGRVFMASAIKLPGFSGPKIVAIKQLKKCSSSD 534

  Fly   815 EYMALLSEFQLLQEV-SHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLR-------------- 864
            |:...|.|..::::| .|||::.|||.||..|...:|:||...|.|..|||
Mosquito   535 EFDEFLDEITMMKKVGKHPNIVALLGCCTIKEPLTMIMEYVGCGDLLEYLRKIRAKHLAKVHQLD 599

  Fly   865 LSRKIECA--GVDFADG------------------------------------------------ 879
            :..::|.|  |::.|.|
Mosquito   600 IGAQLENANSGLNTAPGNNIFGPMVKYLDLLHTSSSNSDASYITQTDTTTRPSVTETTYTALSGT 664

  Fly   880 ---------VEPVNVKMVL------TFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISD 929
                     :...:::.||      .||.||..||.:|..|.:.||||||||:|:.:.|..||||
Mosquito   665 MGDEDNNSTIGSCSLEYVLDHKELHNFAKQIAFGMEHLEGLHITHRDLAARNILIDERKTLKISD 729

  Fly   930 FGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAP 994
            |||:|    ...|:.....:||::|::.|::.|::|::|||||:||::.||:.|||..|||.::.
Mosquito   730 FGLSR----TGIYVNTRNKKVPLRWLSIEAMRDNLYSNKSDVWAFGIVLWEIGTLGGYPYPSVSN 790

  Fly   995 QNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAK-YIDLETN 1058
            ..|::.|:.|.|::|||||:..||.::..||.::||.||||:    :..|.|..:.| |||.  |
Mosquito   791 HELFAYLQEGKRLERPENCTVDVYDLMLQCWREDPNERPSFQ----QISKHLQPHKKIYIDF--N 849

  Fly  1059 AVSNPLY 1065
            .: .|.|
Mosquito   850 EI-EPTY 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	114/358 (32%)
LOC1279581	XP_061512028.1	None