Protein Alignment Ret and Tie

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_061501122.1
• Gene: Tie / 1277092
• VectorBaseID: AGAMI1_010250
• Length: 1339
• Species: Anopheles gambiae
• Alignment Length: 508
• Identity: 140/508 - (27%)
• Similarity: 223/508 - (43%)
• Gaps: 124/508 - (24%)

  Fly   659 AEPLLGVRRGTPPNQPLQ----------------------DPMLLGVLNVAGFECDR-SCMFFVI 700
            |.|:|..|  ||||..|.                      |.:||...:....|..: :...||:
Mosquito   820 AGPVLSTR--TPPNLDLSLAFTSPPPVDHSSGTKKPAVSFDGVLLHHNSDVVIEMRKMNTATFVL 882

  Fly   701 TCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMPLQSGFRFESGD---- 761
            ....:..::::.|.:.:..:..|   :..::...::.:|:      ...|:....|.|..|
Mosquito   883 AGLGMLPIVIIVLYVLKATVFNR---ENKVSHDLERYIPD------GQPPISPVVRLEQSDTSSA 938

  Fly   762 ------AKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALL 820
                  .:.:|.|..|:..::||||.||||.|..|.::||..|.|.:.....::..|.  :..|.
Mosquito   939 TDESIMTEHDFNRGNLRFKSLLGEGNFGQVWKAEADDLAGHLGTTRIVAVKTERSDNG--HGDLK 1001

  Fly   821 SEFQLLQEV-SHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVE--- 881
            :|.:::::: |||||:.|||||...:..|||:|||..|.|.|.||.:|.   |....|..|.
Mosquito  1002 AEAEIMRKLGSHPNVVTLLGACLEQDPQLLIMEYAMRGRLLSLLRAARG---AVNGLAPSVHNNR 1063

  Fly   882 ----PVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRD---VYED 939
                |::.:.:..||..|.:||.|:||.|:||||||||||||....||||.|||::.|   |...
Mosquito  1064 PPIMPLSPRRLTGFAHDIARGMEYISEKKIVHRDLAARNVLLDHNGICKICDFGMSIDLEKVKSS 1128

  Fly   940 DAYLK------------------------------------------------------------ 944
            .|.::
Mosquito  1129 HAQIRMPRSHQHSESRFKFDLSARSFGIGRHHSHGHDHASHGRHGGGAGGGGSGGGHSNSHGHDT 1193

  Fly   945 RSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDR 1009
            :||..:|::|||||:|..|:::.::|||:||::.||:.|||.:|||.::.:.:...:..|.|.:.
Mosquito  1194 KSRPALPIRWMAPEALQYHIFSRETDVWAFGIVLWEIATLGCTPYPSLSGREVVRSVPNGARPEV 1258

  Fly  1010 PENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAVSN 1062
            |.:|...:|.:::..|..:|..||:|    ||....|........||.|..||
Mosquito  1259 PADCRPELYDLMQRTWRKDPRQRPTF----SEARTCLARTLCQWQLEDNDTSN 1307

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	111/349 (32%)
Tie	XP_061501122.1	None