Protein Alignment Ret and LOC1274321

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_061504086.1
• Gene: LOC1274321 / 1274321
• VectorBaseID: AGAMI1_010576
• Length: 1601
• Species: Anopheles gambiae
• Alignment Length: 1264
• Identity: 259/1264 - (20%)
• Similarity: 410/1264 - (32%)
• Gaps: 421/1264 - (33%)

  Fly     9 VTLLTIITQRKHCAAVDVYFPTTSVKFNMPINEESESIFSKIPLAQFQVLRMEDNRLASDY---- 69
            |....:..:|...|:.||..|:.|.....|......:.::::..|:    ...|.||::.|
Mosquito   528 VCSFVVCRERVQAASGDVLPPSASDPTIRPAEPADGATYAELLPAR----NDSDQRLSNVYVDME 588

  Fly    70 ---LYSLE----------------QNPLLRINSSSGEIY-----------------------MRT 92
               |:.|:                |.||  :.|::||.:                       :||
Mosquito   589 ACLLHELDVEQSFQYTNLSSCGPRQQPL--VASAAGESFGASCELPNPTNTDHQRHALQYRRLRT 651

  Fly    93 DYRSPNSSATFLVTAFP---RDQP-----------------DHELLNVSHLSLEVTPQPLEEYCS 137
            ...|.:|....|...:|   .|:|                 :.:.||.|..:|.......|....
Mosquito   652 HASSEDSEVHLLNRQYPCEAADEPGAGEDDEDDDDGAARCTNADELNDSKNNLLREESFDENQRQ 716

  Fly   138 ELEHICFWSSAQYTIAESHGPY--RRKDFFEPV--------------------LIGALNSRAAKY 180
            :|.:...|........|:.|.|  .||:...|.                    .|.|||.:..::
Mosquito   717 QLSNCSTWRRKSTEEGETDGKYLTMRKEVAIPAPEAIPSQEAQWKSSIERHLDHIDALNQKLDEH 781

  Fly   181 --LCPHVSLEYSL-------------------------------NAGSSHFVLKQNRLYTRQTLD 212
              |...:|.||..                               .|.|....:::....|:|..|
Mosquito   782 QRLAARLSEEYEYIRVQTLTRPAVAPQPQKPLPGATKPPTQTFEKANSFREKIRRRIKGTKQDSD 846

  Fly   213 H--------DELNGLNAKAGQLQARITCTVKLSSRDQRKFSRILDIKLLDRNDNGPKLQESSSKF 269
            .        |..:...:.:|:|::|||     :...||:|      :|:...|:      :|...
Mosquito   847 RQADRSVSPDNPDQPESFSGRLRSRIT-----AHHTQRQF------RLMKDTDS------ASPST 894

  Fly   270 DFYLEQPYFQADEEAGKKVIYVDKDTLEANAHLVYAVHNDSHGLFRPDCH--------------- 319
            |..:.:.....:..||:|     |...:|:.....|....|.|  .||.|
Mosquito   895 DRSIAERLPPGNSAAGRK-----KKKRKASKANRAARQQLSRG--GPDGHQPERHQPLHPQQAFS 952

  Fly   320 ----------AYEADHTGRPHTIVSCQLRFSRNGVFRETPYCVSLEARDLTIVSRVDAMSATANV 374
                      |...||:|.|....:..|..|.:...|.|       .|:| |.|......::.|:
Mosquito   953 EDELLAEEQPALSPDHSGGPRATAAGGLGTSFSQTVRAT-------WREL-IHSTNKVKDSSMNL 1009

  Fly   375 CYHINLSKLHESEQELPQALPLR-------------ARQHRIFESEEFNGDSAGRSLSPPTVDYD 426
            ...   |...|.:.:|..|.|.|             .|:|::.       |....|....|.||.
Mosquito  1010 ALR---SDRPEEKLDLIAADPDRQGLLSIRFTFSDGGRKHQLV-------DGMMASDMHTTADYC 1064

  Fly   427 KDVSVYRSAASNFRVVQPDSFLDLMRLRSIRFDIVEDKLGAFGITSTSGIVFVKNPQVLEEAPET 491
            ..:.|.||..:..:...||.                                       :..|||
Mosquito  1065 VPLLVARSEDTQLQAGSPDG---------------------------------------DMRPET 1090

  Fly   492 IYFLNVTWIDQQRL--------SHVRVINVHLVH------------GRPENT------SCELKVK 530
            ..|       .||.        |::|.....|||            ||...|      :|..::.
Mosquito  1091 PVF-------AQRASKAGPSLKSNLRDKLTKLVHKKTASGGSVQSGGRSVATAQEVCRTCSKRIV 1148

  Fly   531 SR-----------SQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYGSCVPESRYCPD 584
            .|           |:|....:.:...:..|    .||.....|:.|.|....|
Mosquito  1149 QRSGSDGGGGMHASRTVLDFRKEFPDIDIC----EGGHDHLDGATSEMINLEY------------ 1197

  Fly   585 HVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSCAPLDEE----- 644
                  |:::.:.           :.||...:.     ||:...||......:..||.||
Mosquito  1198 ------EDIDVLT-----------IKPHKLIDP-----SAAEGGICVSMTLSTNRPLHEEEWFHG 1240

  Fly   645 --PKMKKPRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVI------- 700
              |:.:..|..:||.:.     :.|.|..|...|.     ||:|    |......|::
Mosquito  1241 VLPREEVVRLLRNEGDF-----LVRETTRNDESQT-----VLSV----CWNGHKHFIVQTTAEGH 1291

  Fly   701 ------TCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQA-LPESG-GGDFALMPLQSGFRF 757
                  ..|.:                      |.:.....|: ||.:| .|.....|:..
Mosquito  1292 YRFEGPAFPSI----------------------QELIVHQYQSELPVTGRSGAVLRKPVLR---- 1330

  Fly   758 ESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSE 822
                .:||...:.:.|...:|.|.||.|.|........    |.||||..:......:....|.|
Mosquito  1331 ----ERWELSNDDVILLDKIGRGNFGDVYKAKLKSSKN----TLVAVKTCRMTLPEEQKRKFLQE 1387

  Fly   823 FQLLQEVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKM 887
            .::|::..|||::||:|.|...:..::::|....|||..:||             .....:..:.
Mosquito  1388 GRILKQYDHPNIVKLIGICVQKQPIMIVMELVAGGSLLMFLR-------------KNASTLGQRQ 1439

  Fly   888 VLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPV 952
            ::........||.||.....:||||||||.|:....|.||||||::|:  |::..:.....::|:
Mosquito  1440 MMGMCRDAAAGMRYLESKNCIHRDLAARNCLIGSENIVKISDFGMSRE--EEEYIVSGGMKQIPI 1502

  Fly   953 KWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAV 1017
            ||.|||:|....|||..||||:|:|.||:.:.|.:||.|::.......:..||||..||.....:
Mosquito  1503 KWTAPEALNFGKYTSLCDVWSYGILVWEIFSRGDTPYSGMSNSMARERIDEGYRMPAPEGAPPEM 1567

  Fly  1018 YSIVRTCWADEPNGRPSFKFLASEFEKLL 1046
            |.::..||:.||..||.|..:.|..:.||
Mosquito  1568 YRLMLKCWSYEPESRPHFDEICSVVDALL 1596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	89/277 (32%)
LOC1274321	XP_061504086.1	None