Protein Alignment Ret and LOC1273778

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_061505105.1
• Gene: LOC1273778 / 1273778
• VectorBaseID: AGAMI1_002663
• Length: 2368
• Species: Anopheles gambiae
• Alignment Length: 935
• Identity: 241/935 - (25%)
• Similarity: 369/935 - (39%)
• Gaps: 270/935 - (28%)

  Fly   317 DCHAYEADHTGRPHTIVSCQLRFSRNGV-FRETPYCVSLEARDLTIVSRVDAMSATANVC--YH- 377
            :.:..:.|..|:|...||    :.::|. :|:..|..::..:.|.   ..||.:...|||  |.
Mosquito   183 EAYRLKCDAVGQPAPHVS----WLKDGAEYRDNSYKSTIVFKQLL---PTDAGTYVCNVCNVYGC 240

  Fly   378 INLS---KLHESEQELPQALPLRARQHRIFES-EEFNGDSA-----------GR----------- 416
            :|.:   ::.||.:..|..:     ||...|| .:..||.|           ||
Mosquito   241 VNATTVLEVVESGEHEPAYI-----QHNTMESHSQLQGDPATQDTQVMMRALGRYYPAGATEKRP 300

  Fly   417 ---SLSPPTVDYDKD-----------------VSVYRSAASNFRVVQPDSFLDLMRLRSIRFDIV 461
               :..|...|.|:|                 ..|:.|                        |..
Mosquito   301 QHHTYQPEDADMDEDDDEDGEEEEEEEGPTNGTGVHGS------------------------DTT 341

  Fly   462 EDKLGAFGITST----SGIVFVKNPQVLE------------EAPETIY-FLNVTWIDQQR----- 504
            ||..||...:.|    ...:|.|..|:.:            ..|...| ..|:||....|
Mosquito   342 EDSAGAVNGSGTPPPDRAPIFTKKDQMTKIVSKPSGNMVRLRCPADGYPKPNITWTKDGRKIERA 406

  Fly   505 LSHVRVIN--VHLVHGRPENTSCELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAM 567
            :..|:.:|  :.|....|::        |.|.||| :..|..|:.:              :....
Mosquito   407 MGQVKKVNWAIVLEDLVPQD--------SGSYTCA-VCNQVGCINF--------------TTKLE 448

  Fly   568 FGTRYGSCVPESRYCPDHV-----------CDPLEELNP--------------MACPQDCTPAGR 607
            ...|: ...|.....|.:|           |..|.:|.|              |:.|::.|...|
Mosquito   449 VKDRF-PARPHITERPKNVTALVNTTVIFSCPILSDLEPHIEWVKLGLVDLENMSIPENVTKLKR 512

  Fly   608 ------IVGPHSSNENKRGIYSASGTCICED-----NGKCSCAPLDEEPKMKKPRKRKNETEAEP 661
                  ::...:......|.|    |||..:     |.......|||.|....|......|.:..
Mosquito   513 DPDNPEVLTLENVTHADEGWY----TCIAANSLGATNESAYLQVLDELPPDDTPTAHPVRTHSTL 573

  Fly   662 LLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITC--PLLFVLLLLCLLIAQRKMLQRR 724
            ::|:                              ..|:..|  .|..:::::|..:.:.||..|.
Mosquito   574 IMGM------------------------------TIFLCACFTVLAVIVIIVCKKLKREKMKHRA 608

  Fly   725 LGKQSMTTSS----KQALPES---GGGDFALMPL-----QSGFRFESG--------------DAK 763
            :...:..|..    ||.:.||   |..:...||:     |.....:||              |..
Mosquito   609 MEHVNQWTKKVIVLKQPVVESSIPGMSEALQMPIVRIEKQRSTLVQSGNCDPTMISEYEFPIDLN 673

  Fly   764 WEFPREKLQLDTVLGEGEFGQVLKGFATE-IAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQ 827
            |||||.||.|...||||.||:|:...|.. :.|.|. |.|||||||:|....:...|:.|.::::
Mosquito   674 WEFPRNKLHLGKSLGEGMFGKVVMAEAHGLVKGHPS-TVVAVKMLKEGHTDADVKDLVCEMEVMK 737

  Fly   828 EV-SHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVN------- 884
            .: .|.|:|.|||.|.......:|:|||.:|:|:::||..|        |....|..|
Mosquito   738 MIGKHVNIINLLGCCCKDGPLYVIVEYAPHGNLKNFLRSHR--------FGSNYEATNEKEKKIL 794

  Fly   885 -VKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRD 948
             .|.:::||:||.:||.:|:..:.:||||||||:|::|..:.||:||||.||:::.:.|.|.:..
Mosquito   795 TQKELISFAYQIARGMEHLASRRCIHRDLAARNILVSDNYVMKIADFGLARDIHDQEYYRKTTTG 859

  Fly   949 RVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAP-QNLWSLLKTGYRMDRPEN 1012
            ::|::|||||||.:..|.|:|||||||||.||::|||.:|||.|.. .||...||.|.||::|..
Mosquito   860 KLPIRWMAPESLEEKFYDSQSDVWSFGVLLWEIMTLGGNPYPSIPTWDNLLEHLKKGKRMEKPPL 924

  Fly  1013 CSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLG--NNAKYIDLETNAVSNPLYCGDDSALITT 1075
            ||..:|..:|.||...|..||:|..:....::|:.  :|.:|:||....:..| ...|||   ..
Mosquito   925 CSIEIYLFMRECWHYRPEERPTFSEIVQHLDRLVSITSNEEYLDLGLPQLETP-PSSDDS---DD 985

  Fly  1076 ELGEPESLQHLWSPPKIAYDIHDQA 1100
            ::.|.|.            |..|||
Mosquito   986 DVEEDEE------------DCDDQA 998

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	118/291 (41%)
LOC1273778	XP_061505105.1	None