Protein Alignment Ret and LOC1273258

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_061507028.1
• Gene: LOC1273258 / 1273258
• VectorBaseID: AGAMI1_012797
• Length: 1261
• Species: Anopheles gambiae
• Alignment Length: 553
• Identity: 146/553 - (26%)
• Similarity: 215/553 - (38%)
• Gaps: 144/553 - (26%)

  Fly   765 EFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSN-SVEYMALLSEFQLLQE 828
            |....:|.|..|:|.|.|.:|.:.|      |.| ..||||..::... .|....:|.|.:|...
Mosquito    97 EIQYHELDLKEVIGVGGFSKVHRAF------LNG-EEVAVKASRQDDEFEVARQNVLQEAKLFWS 154

  Fly   829 VSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAW 893
            :.|||::.|.|.|...:...|::||||.|||...| ..|||            |.||  ::.:|.
Mosquito   155 LKHPNIVSLKGVCLDPKTLCLVMEYARGGSLNKIL-AGRKI------------PPNV--LVDWAI 204

  Fly   894 QICKGMAYL---SELKLVHRDLAARNVLLAD--------GKICKISDFGLTRDVYEDDAYLKRSR 947
            ||.:||.||   :.:.::||||.:.|||:::        .|..||:||||.|:.|.    ..|..
Mosquito   205 QIARGMKYLHCEAPISVIHRDLKSSNVLISESIQHGHLLNKTLKITDFGLAREAYR----TTRMS 265

  Fly   948 DRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGY------- 1005
            ......||.||.:....|:..|||||:|||.|||:| |.:||.|      :..|...|
Mosquito   266 AAGTFAWMPPEVIKSGTYSKASDVWSYGVLLWELLT-GETPYKG------FDSLSVAYGVAVNTL 323

  Fly  1006 RMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAVSNPLYCGDDS 1070
            .:..|:.|.|:...::::||..:|:.|||||    :.||         ||:..|.|.......:|
Mosquito   324 ALPIPKTCPESWGKLMKSCWEIDPHRRPSFK----DIEK---------DLDIIARSGFAQTPHES 375

  Fly  1071 ALITTELG----EPESLQHLWSPPKIAYDIHDQATSYDQS------------------EEEMPVT 1113
             ..|.:.|    ..|.||.|....|......::..|.::.                  |:|:...
Mosquito   376 -FHTMQDGWKKEIAEVLQELRKKEKAFKSFEEELRSKEEELTRVQQEQRYKEENLAKREQELHAR 439

  Fly  1114 STAPPGYDL--------PRP------------LLDATANGQVLRYENDLRFPLNIRKSSCTPSYS 1158
            .....|.:|        |.|            .|...|.||: ...:|.|..:.|:.::......
Mosquito   440 EIELLGRELKILINQNTPTPKKRKGKFSKSRIKLIKKAPGQI-SLPSDFRHTITIQHTAIRDERQ 503

  Fly  1159 NMTSEP--PAT------------------TSLPHYSVPVKRGRSYLDMTNKSLIPDNLDSREFEK 1203
            .:.:.|  |||                  .|..|     :|.||:|.....|..|     ::|.|
Mosquito   504 RIDTPPGSPATRLRTIVFPGDVIKGKTWGPSTLH-----QRERSHLPTMRPSARP-----QQFSK 558

  Fly  1204 HLSKTISFRFSSLLNLSETKEV-----SPGWQA 1231
            ........|.::|...|...|:     ...|.|
Mosquito   559 SAPNLDKSRATALSASSSRHEILDYDTDEAWYA 591

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	99/297 (33%)
LOC1273258	XP_061507028.1	None