Protein Alignment Ret and Shark

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_061517294.1
• Gene: Shark / 1272509
• VectorBaseID: AGAMI1_002383
• Length: 1207
• Species: Anopheles gambiae
• Alignment Length: 416
• Identity: 129/416 - (31%)
• Similarity: 196/416 - (47%)
• Gaps: 67/416 - (16%)

  Fly   719 KMLQRRLGKQSMTTSSKQALPESGGGDFALMPLQ---SGFRFESGDAKWEFPREKLQLDTVLGEG 780
            |:.:|....||   |..:|...||...|..|..|   |....:.....:..|:|.:..:||||.|
Mosquito   813 KLFERLDSNQS---SFSRASVLSGESVFFAMFQQQQSSNTAAQPEGPNYFIPKECIHAETVLGRG 874

  Fly   781 EFGQVLKGF----ATEIAG----------------LPGITTVAVKMLKKGSNSVEYMALLSEFQL 825
            |||.|.:||    ..:|||                :.|...||:|.:.......:....|.|..:
Mosquito   875 EFGFVYQGFLDPWPVDIAGGGYQSGGVAHKTSPPVMMGRVPVAIKKVMDSQERRDRTDFLREASV 939

  Fly   826 LQEVSHPNVIKLLGACTSSEAPLLII-EYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKM-V 888
            :..:.|..:::|:|.|..  .||::: |....||:..|:..::             ..:|.|. :
Mosquito   940 MIRLRHNCIVRLIGICKG--PPLIMVQELISLGSMLVYITKNK-------------ATINPKQEM 989

  Fly   889 LTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSR-DRVPV 952
            :.:|.||..||.||.|...|||||||||:|||:....|||||||:|.:.....|.:.|: .:.|:
Mosquito   990 MIWAAQIASGMQYLEEKHFVHRDLAARNILLANKYQAKISDFGLSRAIGAGQEYYRASQGGKWPI 1054

  Fly   953 KWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAV 1017
            ||.||||.....::..||||||||..||:.:.||.||..:....:..|::...|:.||:.|.:.|
Mosquito  1055 KWYAPESFNYGTFSHASDVWSFGVTLWEMFSYGAPPYHDMKGAEVIKLIEEDQRLSRPDACPDKV 1119

  Fly  1018 YSIVRTCWADEPNGRPSFKFLASEF---------EKLLGN----NAKYIDLETNAVSNPLYCGDD 1069
            :.::|.||...|..||:|:||...|         ::|:|.    ||....| |:|..:.....::
Mosquito  1120 FEVMRNCWQYNPKLRPTFRFLHRFFSDDIEYQNLQELVGTGVEINANATTL-THAGGSSSSSSNN 1183

  Fly  1070 SALITTELGEPESLQHLWSPPKIAYD 1095
            :|.|||.  ||       :.|::|.|
Mosquito  1184 TATITTV--EP-------TVPEVASD 1200

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	101/314 (32%)
Shark	XP_061517294.1	None