DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ret and Flt4

DIOPT Version :10

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_446104.2 Gene:Flt4 / 114110 RGDID:621737 Length:1363 Species:Rattus norvegicus


Alignment Length:1375 Identity:323/1375 - (23%)
Similarity:525/1375 - (38%) Gaps:396/1375 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 EDNRLASDYLYSLEQNPLLRINS-------SSGEIYMRTDY-----RSPNSSATFLVTAFPRD-- 111
            ||.::..| ....|..|..::.|       ::|..|....|     ....:::|::   |.||  
  Rat    76 EDTQVVQD-CEGTEARPYCKVLSLAQTHANNTGSYYCYYKYIKARIEGTTAASTYV---FVRDFE 136

  Fly   112 -----QPDHELLN----------VSHLSLEVTPQPLEEYCSELE---HICFWSSAQYTIAESHGP 158
                 :||..|:|          ||...|.:|   |....|.|.   ....|..           
  Rat   137 QPFINKPDTLLVNRKDSMWVPCLVSIPGLNIT---LRSQSSVLHPDGQEVLWDD----------- 187

  Fly   159 YRRKDFFEPVLIGALNSRAAKYLCPHVSLEYSLNAGSSHFV-------LKQNRLYTRQTLDHDEL 216
              |:....|.|:    .|.|.|      |:.....|...|:       :..|.||..|......|
  Rat   188 --RRGMRVPTLL----LRDALY------LQCETTWGDQDFLSNPFLVHITGNELYDIQLYPKKSL 240

  Fly   217 NGLNAKAGQLQARITCTV---------------------------KLSSRDQRKFSRILDIKLLD 254
            ..|   .|: :..:.|||                           :.|.:...:.|.||.|..:.
  Rat   241 ELL---VGE-KLVLNCTVWAEFDSGVTFDWDYPGKQAERAKWVPERRSQQTHTELSSILTIHNVS 301

  Fly   255 RNDNGPKLQESSSKFDFYLEQPYFQADEEAGKKVIYVDKDTLEANA-------HLVYAVHNDSHG 312
            ::|.||.:.|:::....:.|.......|:....|.::....|||.|       .:..|.:.....
  Rat   302 QHDLGPYVCEANNGIQRFRESTEVIVHEKPFISVEWLKGPVLEATAGDEMVKLPVKLAAYPPPEF 366

  Fly   313 LFRPDCHAYEADHTGRPHTIVSCQLRFSRNGVFRETPYCVSLEARDLTIVSRVDAMSATANVCYH 377
            .:..|..|....|  .||.:|..::..:..||     |.::|......:...: ::....||..|
  Rat   367 QWYKDRKAVTGRH--NPHALVLKEVTEASAGV-----YTLALWNSAAGLRQNI-SLELVVNVPPH 423

  Fly   378 INLSKLHESEQELPQALPLRARQHRIFESEEFNGDSAGRSLSPPTVDYDKDVSV---YRS----- 434
            |     ||.|...|......:||                :|:..|....:.:||   :|.     
  Rat   424 I-----HEKEASSPSIYSRHSRQ----------------TLTCTTYGVPQPLSVQWHWRPWTPCK 467

  Fly   435 --AASNFRVVQPDSFLDLMRLRSIRFDIVEDKLGAF-GITSTSGIVFVKNPQ----VLEEAPETI 492
              |..:.|..||..  .:.:.|..:....:|.:... .:.:.:..|..||..    |:::|..:.
  Rat   468 TFAQRSLRRRQPRD--GMPQCRDWKEVTTQDAVNPIESLDTWTESVEGKNKTVSKLVIQDANVSA 530

  Fly   493 YFLNVTW--IDQ-QRLSHVRVINVHLVHGRPENTSCE-------LKVKSRSQTCAQIKYQSQCVR 547
            .:..|.:  :.| :||.:..|..:      |:..|.|       |:.:|...:|....|..:.:|
  Rat   531 MYKCVVFNKVGQDERLIYFYVTTI------PDGFSIESEPSEDPLEGQSVRLSCRADNYTYEHLR 589

  Fly   548 YCGL-------ATGGG---SCQWRGSNSAMFGTRYGSCVPES--------------RYCP----D 584
            :..|       |.|..   .|:    |..:|.|...:.:.|:              |..|    |
  Rat   590 WYRLNLSTLHDAQGNPLLLDCK----NVHLFATPLEANLEEAEPGARHATLSLNIPRVAPEDEGD 650

  Fly   585 HVCDPLEELN-----------------------------------PMACPQDCTPAGRIVGPHSS 614
            :||:..:..|                                   .|.||        :.|.|..
  Rat   651 YVCEVQDRRNQDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMRCP--------VAGAHVP 707

  Fly   615 N----ENKRGIYSASGTCICEDNGKCSCAPLDEEPK---MKKPRKRKNETEAEPLLGVRRGTPPN 672
            :    :::|.:...||..:.:.|.:.|...:.||..   :......|....:...:.| .|:...
  Rat   708 SIVWYKDERLLEKESGIDLADSNQRLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAV-EGSEDK 771

  Fly   673 QPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQA 737
            ..::..:|:|...:|.|       |:|:      :||:.|.:        :|.....:.|.....
  Rat   772 GSMEIVILIGTGVIAVF-------FWVL------LLLIFCNM--------KRPAHADIKTGYLSI 815

  Fly   738 LPESGGGDFALMPLQSGFRFESGD-AKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITT 801
            :.:.|.     :||:....:.|.| ::||||||:|.|..|||.|.||:|::..|..|.......|
  Rat   816 IMDPGE-----VPLEEQCEYLSYDVSQWEFPRERLHLGRVLGHGAFGKVVEASAFGINKGSSCDT 875

  Fly   802 VAVKMLKKGSNSVEYMALLSEFQLLQEV-SHPNVIKLLGACTSSEAPLL-IIEYARYGSLRSYLR 864
            |||||||:|:.:.|:.||:||.::|..: :|.||:.||||||....||: |:|:.:||:|.::||
  Rat   876 VAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPNGPLMVIVEFCKYGNLSNFLR 940

  Fly   865 LSRK-------------------IECAGVD--------------FADG----------------- 879
            :.|:                   :|.|..|              |..|                 
  Rat   941 VKRETFDPYAEKSPEQRRRFRAMVEGAKADRRRLGSTDRALFTRFLMGKGSARRAPFVQEAEDLW 1005

  Fly   880 VEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLK 944
            :.|:.::.::.:::|:..||.:|:..|.:||||||||:||::..|.||.||||.||:|:|..|::
  Rat  1006 LSPLTMEDLVCYSFQVALGMEFLASRKCIHRDLAARNILLSESDIVKICDFGLARDIYKDPDYVR 1070

  Fly   945 RSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGI-APQNLWSLLKTGYRMD 1008
            :...|:|:|||||||:.|.|||::|||||||||.||:.:||||||||: ..:.....||.|.||.
  Rat  1071 KGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLKDGTRMR 1135

  Fly  1009 RPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLL-GNNAKYIDLETNAVSNPLYCGDD--- 1069
            .||..:.|:..|:::||:.:|..||:|..|......|| |...:..:.|..|:.:.....:|   
  Rat  1136 APELATPAIRHIMQSCWSGDPKARPAFSDLVEILGDLLQGGGWQEEEEECMALHSSQSSEEDGFM 1200

  Fly  1070 ----SALITTELGEPESLQHLWSPPKIAYDIHDQATSYDQSEEEMPVTSTAPPGYDLPRPLLDAT 1130
                :||..|| .:.||     |||.:  ..|..|.                             
  Rat  1201 QASTTALHITE-ADAES-----SPPSM--HCHSLAA----------------------------- 1228

  Fly  1131 ANGQVLRYENDLRFPLNIRKSSCTPSYSNMTS--EPPATTSLPHYSVPVKRGRSYLDMTNKSLIP 1193
                  ||.|.:.||..:.:.:..|..|.|.:  |.|.|        |.....|..:.|:..:: 
  Rat  1229 ------RYYNCVSFPGRLVRGTKAPGSSRMKTFEELPMT--------PTTYKASVDNQTDSGMV- 1278

  Fly  1194 DNLDSREFEK 1203
              |.|.|||:
  Rat  1279 --LASEEFEQ 1286

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864 129/332 (39%)
Flt4NP_446104.2 Ig_2 137..224 CDD:464026 21/112 (19%)
IgI_VEGFR 230..329 CDD:409448 18/102 (18%)
Ig strand A 230..234 CDD:409448 1/3 (33%)
Ig strand A' 240..244 CDD:409448 2/6 (33%)
Ig strand B 246..255 CDD:409448 2/9 (22%)
Ig strand C 262..267 CDD:409448 0/4 (0%)
Ig strand C' 270..272 CDD:409448 0/1 (0%)
Ig strand D 276..284 CDD:409448 0/7 (0%)
Ig strand E 289..297 CDD:409448 3/7 (43%)
Ig strand F 307..313 CDD:409448 2/5 (40%)
Ig strand G 318..324 CDD:409448 1/5 (20%)
Ig 331..418 CDD:472250 16/94 (17%)
Ig strand B 352..356 CDD:409353 0/3 (0%)
Ig strand C 365..369 CDD:409353 0/3 (0%)
Ig strand E 382..386 CDD:409353 1/3 (33%)
Ig strand F 396..401 CDD:409353 2/9 (22%)
Ig strand G 411..414 CDD:409353 0/3 (0%)
IG_like 570..663 CDD:214653 18/96 (19%)
Ig strand B 574..578 CDD:409353 0/3 (0%)
Ig strand C 587..591 CDD:409353 1/3 (33%)
Ig strand E 636..640 CDD:409353 0/3 (0%)
Ig strand F 650..655 CDD:409353 3/4 (75%)
Ig 678..765 CDD:472250 13/94 (14%)
Ig strand B 695..699 CDD:409353 1/3 (33%)
Ig strand C 708..712 CDD:409353 0/3 (0%)
Ig strand E 731..735 CDD:409353 0/3 (0%)
Ig strand F 745..750 CDD:409353 0/4 (0%)
VEGFR-2_TMD 770..804 CDD:375470 10/54 (19%)
Protein Kinases, catalytic domain 837..1175 CDD:473864 134/337 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1289..1330
Blue background indicates that the domain is not in the aligned region.

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