DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ret and Flt4

DIOPT Version :9

Sequence 1:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_446104.2	Gene:	Flt4 / 114110	RGDID:	621737	Length:	1363	Species:	Rattus norvegicus

Alignment Length:	1375	Identity:	323/1375 - (23%)
Similarity:	525/1375 - (38%)	Gaps:	396/1375 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 EDNRLASDYLYSLEQNPLLRINS-------SSGEIYMRTDY-----RSPNSSATFLVTAFPRD-- 111
            ||.::..| ....|..|..::.|       ::|..|....|     ....:::|::   |.||
  Rat    76 EDTQVVQD-CEGTEARPYCKVLSLAQTHANNTGSYYCYYKYIKARIEGTTAASTYV---FVRDFE 136

  Fly   112 -----QPDHELLN----------VSHLSLEVTPQPLEEYCSELE---HICFWSSAQYTIAESHGP 158
                 :||..|:|          ||...|.:|   |....|.|.   ....|..
  Rat   137 QPFINKPDTLLVNRKDSMWVPCLVSIPGLNIT---LRSQSSVLHPDGQEVLWDD----------- 187

  Fly   159 YRRKDFFEPVLIGALNSRAAKYLCPHVSLEYSLNAGSSHFV-------LKQNRLYTRQTLDHDEL 216
              |:....|.|:    .|.|.|      |:.....|...|:       :..|.||..|......|
  Rat   188 --RRGMRVPTLL----LRDALY------LQCETTWGDQDFLSNPFLVHITGNELYDIQLYPKKSL 240

  Fly   217 NGLNAKAGQLQARITCTV---------------------------KLSSRDQRKFSRILDIKLLD 254
            ..|   .|: :..:.|||                           :.|.:...:.|.||.|..:.
  Rat   241 ELL---VGE-KLVLNCTVWAEFDSGVTFDWDYPGKQAERAKWVPERRSQQTHTELSSILTIHNVS 301

  Fly   255 RNDNGPKLQESSSKFDFYLEQPYFQADEEAGKKVIYVDKDTLEANA-------HLVYAVHNDSHG 312
            ::|.||.:.|:::....:.|.......|:....|.::....|||.|       .:..|.:.....
  Rat   302 QHDLGPYVCEANNGIQRFRESTEVIVHEKPFISVEWLKGPVLEATAGDEMVKLPVKLAAYPPPEF 366

  Fly   313 LFRPDCHAYEADHTGRPHTIVSCQLRFSRNGVFRETPYCVSLEARDLTIVSRVDAMSATANVCYH 377
            .:..|..|....|  .||.:|..::..:..||     |.::|......:...: ::....||..|
  Rat   367 QWYKDRKAVTGRH--NPHALVLKEVTEASAGV-----YTLALWNSAAGLRQNI-SLELVVNVPPH 423

  Fly   378 INLSKLHESEQELPQALPLRARQHRIFESEEFNGDSAGRSLSPPTVDYDKDVSV---YRS----- 434
            |     ||.|...|......:||                :|:..|....:.:||   :|.
  Rat   424 I-----HEKEASSPSIYSRHSRQ----------------TLTCTTYGVPQPLSVQWHWRPWTPCK 467

  Fly   435 --AASNFRVVQPDSFLDLMRLRSIRFDIVEDKLGAF-GITSTSGIVFVKNPQ----VLEEAPETI 492
              |..:.|..||..  .:.:.|..:....:|.:... .:.:.:..|..||..    |:::|..:.
  Rat   468 TFAQRSLRRRQPRD--GMPQCRDWKEVTTQDAVNPIESLDTWTESVEGKNKTVSKLVIQDANVSA 530

  Fly   493 YFLNVTW--IDQ-QRLSHVRVINVHLVHGRPENTSCE-------LKVKSRSQTCAQIKYQSQCVR 547
            .:..|.:  :.| :||.:..|..:      |:..|.|       |:.:|...:|....|..:.:|
  Rat   531 MYKCVVFNKVGQDERLIYFYVTTI------PDGFSIESEPSEDPLEGQSVRLSCRADNYTYEHLR 589

  Fly   548 YCGL-------ATGGG---SCQWRGSNSAMFGTRYGSCVPES--------------RYCP----D 584
            :..|       |.|..   .|:    |..:|.|...:.:.|:              |..|    |
  Rat   590 WYRLNLSTLHDAQGNPLLLDCK----NVHLFATPLEANLEEAEPGARHATLSLNIPRVAPEDEGD 650

  Fly   585 HVCDPLEELN-----------------------------------PMACPQDCTPAGRIVGPHSS 614
            :||:..:..|                                   .|.||        :.|.|..
  Rat   651 YVCEVQDRRNQDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSLEMRCP--------VAGAHVP 707

  Fly   615 N----ENKRGIYSASGTCICEDNGKCSCAPLDEEPK---MKKPRKRKNETEAEPLLGVRRGTPPN 672
            :    :::|.:...||..:.:.|.:.|...:.||..   :......|....:...:.| .|:...
  Rat   708 SIVWYKDERLLEKESGIDLADSNQRLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAV-EGSEDK 771

  Fly   673 QPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQA 737
            ..::..:|:|...:|.|       |:|:      :||:.|.:        :|.....:.|.....
  Rat   772 GSMEIVILIGTGVIAVF-------FWVL------LLLIFCNM--------KRPAHADIKTGYLSI 815

  Fly   738 LPESGGGDFALMPLQSGFRFESGD-AKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITT 801
            :.:.|.     :||:....:.|.| ::||||||:|.|..|||.|.||:|::..|..|.......|
  Rat   816 IMDPGE-----VPLEEQCEYLSYDVSQWEFPRERLHLGRVLGHGAFGKVVEASAFGINKGSSCDT 875

  Fly   802 VAVKMLKKGSNSVEYMALLSEFQLLQEV-SHPNVIKLLGACTSSEAPLL-IIEYARYGSLRSYLR 864
            |||||||:|:.:.|:.||:||.::|..: :|.||:.||||||....||: |:|:.:||:|.::||
  Rat   876 VAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPNGPLMVIVEFCKYGNLSNFLR 940

  Fly   865 LSRK-------------------IECAGVD--------------FADG----------------- 879
            :.|:                   :|.|..|              |..|
  Rat   941 VKRETFDPYAEKSPEQRRRFRAMVEGAKADRRRLGSTDRALFTRFLMGKGSARRAPFVQEAEDLW 1005

  Fly   880 VEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLK 944
            :.|:.::.::.:::|:..||.:|:..|.:||||||||:||::..|.||.||||.||:|:|..|::
  Rat  1006 LSPLTMEDLVCYSFQVALGMEFLASRKCIHRDLAARNILLSESDIVKICDFGLARDIYKDPDYVR 1070

  Fly   945 RSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGI-APQNLWSLLKTGYRMD 1008
            :...|:|:|||||||:.|.|||::|||||||||.||:.:||||||||: ..:.....||.|.||.
  Rat  1071 KGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLKDGTRMR 1135

  Fly  1009 RPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLL-GNNAKYIDLETNAVSNPLYCGDD--- 1069
            .||..:.|:..|:::||:.:|..||:|..|......|| |...:..:.|..|:.:.....:|
  Rat  1136 APELATPAIRHIMQSCWSGDPKARPAFSDLVEILGDLLQGGGWQEEEEECMALHSSQSSEEDGFM 1200

  Fly  1070 ----SALITTELGEPESLQHLWSPPKIAYDIHDQATSYDQSEEEMPVTSTAPPGYDLPRPLLDAT 1130
                :||..|| .:.||     |||.:  ..|..|.
  Rat  1201 QASTTALHITE-ADAES-----SPPSM--HCHSLAA----------------------------- 1228

  Fly  1131 ANGQVLRYENDLRFPLNIRKSSCTPSYSNMTS--EPPATTSLPHYSVPVKRGRSYLDMTNKSLIP 1193
                  ||.|.:.||..:.:.:..|..|.|.:  |.|.|        |.....|..:.|:..::
  Rat  1229 ------RYYNCVSFPGRLVRGTKAPGSSRMKTFEELPMT--------PTTYKASVDNQTDSGMV- 1278

  Fly  1194 DNLDSREFEK 1203
              |.|.|||:
  Rat  1279 --LASEEFEQ 1286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	129/332 (39%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	126/323 (39%)
Flt4	NP_446104.2	Ig_2	137..220	CDD:404734	21/108 (19%)
		IgI_VEGFR	230..329	CDD:409448	18/102 (18%)
		Ig strand B	248..252	CDD:409448	0/3 (0%)
		Ig strand C	263..267	CDD:409448	0/3 (0%)
		Ig strand E	293..297	CDD:409448	2/3 (67%)
		Ig strand F	307..312	CDD:409448	1/4 (25%)
		Ig strand G	320..323	CDD:409448	1/2 (50%)
		Ig	331..418	CDD:416386	16/94 (17%)
		Ig strand A	332..337	CDD:409353	1/4 (25%)
		Ig strand A'	342..347	CDD:409353	3/4 (75%)
		Ig strand B	349..360	CDD:409353	0/10 (0%)
		Ig strand C	364..370	CDD:409353	0/5 (0%)
		Ig strand C'	372..375	CDD:409353	0/2 (0%)
		Ig strand D	378..380	CDD:409353	1/3 (33%)
		Ig strand E	382..387	CDD:409353	2/4 (50%)
		Ig strand F	395..403	CDD:409353	4/12 (33%)
		Ig strand G	409..418	CDD:409353	0/9 (0%)
		IG_like	570..663	CDD:214653	18/96 (19%)
		Ig strand B	574..578	CDD:409353	0/3 (0%)
		Ig strand C	587..591	CDD:409353	1/3 (33%)
		Ig strand E	636..640	CDD:409353	0/3 (0%)
		Ig strand F	650..655	CDD:409353	3/4 (75%)
		IGc2	693..755	CDD:197706	12/69 (17%)
		Ig strand B	695..699	CDD:409353	1/3 (33%)
		Ig strand C	708..712	CDD:409353	0/3 (0%)
		Ig strand E	731..735	CDD:409353	0/3 (0%)
		Ig strand F	745..750	CDD:409353	0/4 (0%)
		VEGFR-2_TMD	770..804	CDD:375470	10/54 (19%)
		PKc_like	837..1175	CDD:419665	134/337 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1289..1330
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910