DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ret and Abl2

DIOPT Version :10

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_033725.2 Gene:Abl2 / 11352 MGIID:87860 Length:1182 Species:Mus musculus


Alignment Length:501 Identity:154/501 - (30%)
Similarity:227/501 - (45%) Gaps:94/501 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly   763 KWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQ 827
            |||..|..:.:...||.|::|:|..|...:.:     .|||||.||:.:..||  ..|.|..:::
Mouse   280 KWEMERTDITMKHKLGGGQYGEVYVGVWKKYS-----LTVAVKTLKEDTMEVE--EFLKEAAVMK 337

  Fly   828 EVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFA 892
            |:.|||:::|||.||......::.||..||:|..|||     ||:.       |.|...::|..|
Mouse   338 EIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLR-----ECSR-------EEVTAVVLLYMA 390

  Fly   893 WQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAP 957
            .||...|.||.:...:||||||||.|:.:..:.|::||||:| :...|.|...:..:.|:||.||
Mouse   391 TQISSAMEYLEKKNFIHRDLAARNCLVGENHVVKVADFGLSR-LMTGDTYTAHAGAKFPIKWTAP 454

  Fly   958 ESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVR 1022
            ||||.:.::.|||||:||||.||:.|.|.||||||....::.||:.||||::||.|...||.::|
Mouse   455 ESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMR 519

  Fly  1023 TCWADEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAVSNPLYCGDDSAL---ITTELGEPES-- 1082
            .||...|..||||......||.:.                     .||::   :..|||...|  
Mouse   520 ACWKWSPADRPSFAETHQAFETMF---------------------HDSSISEEVAEELGRTASSS 563

  Fly  1083 -----LQHLWSPPKIAYDIHDQATSYDQSE-----EEMPVTSTAPPGY-----------DLPRPL 1126
                 |..|...|.....:..|..:.:..:     .|...:|:||.|:           .|||..
Mouse   564 SVVPYLPRLPLLPSKTRTLRKQGENKENLDGGLDAAESLASSSAPAGFIRSTQASSGSPALPRKQ 628

  Fly  1127 LDATANGQVLRYENDLRFPLNIRKSSCTPSYSNMTSEPPATTSLPHYSVPVKRGRSYLDMTNKSL 1191
            .|.:.: .:|....:..|..: ||.....|:....:.|          .|.||..|:.:|.|   
Mouse   629 RDKSPS-SLLEDAKETCFTRD-RKGGFFSSFMKKRNAP----------TPPKRSSSFREMEN--- 678

  Fly  1192 IPDNLDSREFEKHLSKTISFRFSSLLNLSETK--EVSPGWQAEDAV 1235
                      :.|....::..||.:.:|....  .|:|..|..:.|
Mouse   679 ----------QPHKKYELTGNFSPVASLQHADGFSVAPSQQEPNLV 714

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864 111/278 (40%)
Abl2NP_033725.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..42
CAP 2..106
SH3_Abl 111..164 CDD:212784
SH2_ABL 169..262 CDD:198189
PTKc_Abl 281..543 CDD:270645 114/281 (41%)
Kinase activation loop. /evidence=ECO:0000250 427..451 8/24 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 612..642 5/30 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 655..674 6/28 (21%)
Nuclear localization signal. /evidence=ECO:0000255 659..661 0/1 (0%)
F-actin-binding 695..930 5/20 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 765..796
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 809..858
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..1059
F-actin-binding 1020..1182
FABD 1063..1182 CDD:197885
Blue background indicates that the domain is not in the aligned region.

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