back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ret and tie1

DIOPT Version :9

Sequence 1:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	XP_002931650.3	Gene:	tie1 / 100496664	XenbaseID:	XB-GENE-922217	Length:	1127	Species:	Xenopus tropicalis

Alignment Length:	864	Identity:	219/864 - (25%)
Similarity:	343/864 - (39%)	Gaps:	225/864 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   326 TGRPHTI-VSCQLRFSRNGVFRETPYCVSLEARDLTIVSRVDAMSATANVCYHINLS-------- 381
            :|.|..| .|.:||.....|...:.  ..|:....|....|.:::.|.|..:...:|
Frog   366 SGNPQPIRESIELRRPDGSVLAASK--AVLDRERSTCEFAVQSLTLTDNGLWECRVSTTGGQDSR 428

  Fly   382 --KLHESEQELPQALPL----RARQHRIFESEEFNGDSAGRSLSPPTVDYDKDVSVYRSAASNFR 440
              ::|.....||...||    |::|..:.....|:||....|:.......|.|     |...|..
Frog   429 KFQVHVKVPPLPIEPPLLLDRRSQQLTLSPLHNFSGDGPIISIKLHYKPKDND-----SPWKNIV 488

  Fly   441 VVQPDSFLDLMRLRSIRFDIV-----------EDKLGAFGITSTSGIVFVKNPQVLEEAPETIYF 494
            |.|.::.: |.:|:.:...::           |..||...:..|........|.:...|.|....
Frog   489 VKQKENII-LQKLKPVTSYLIRAQLSRPGPGGEGPLGPLAVMETDCQEPTVKPVIKGHAVEDRNT 552

  Fly   495 LNVTW-----------------------IDQQRLSHVRVINVHLVHGRPENTSCELKVKSRSQTC 536
            |.::|                       |.|:.::.:.|:: ..|:|...|....|||
Frog   553 LYISWNLPSTPVIGNGFLLQIYHPENHLIRQENITSMYVLS-RKVYGLHANKEYTLKV------- 609

  Fly   537 AQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYGSCVPE-----------------SRYCPD 584
              :.|.               |:..|..|..|.....|..|.                 |...||
Frog   610 --LIYH---------------CRNLGPPSDPFVVTIHSKGPSPPKDLRAEPISRDSIKLSWLPPD 657

  Fly   585 HVCDP-------LEELNPMACPQDCTPAGRIVGPHSSNENK-----RGIYSASGTCICEDNGKCS 637
               ||       ..|..|:..|      |......:.|:|:     .|:.:::
Frog   658 ---DPNGGIIKYTVESRPVGIP------GEPQWADTENQNQTWHIISGLNAST------------ 701

  Fly   638 CAPLDEEPKMKKPRKRKN-ETEAEPLLGVRR--------GTPPNQPLQDP--------MLLGVLN 685
                     ..:.|.|.| :...|..|.|:.        ..||:...::|        ::|.::.
Frog   702 ---------FYQFRVRANSKVPGEWSLSVQSTAHSLEIGSQPPSMESKNPRPSGSSHQLILAIIG 757

  Fly   686 VAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMP 750
            .....|      |.|      :|.||.|...::....||          :....:||.|:..::.
Frog   758 SVSITC------FTI------ILALLALFCIKKNFFHRR----------RMFTYQSGSGEETILQ 800

  Fly   751 LQSGF------------RFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVA 803
            ..||.            .|.....:|    |.::.:.|:|||.||||:|....:....   ...|
Frog   801 FSSGTLTLSRRPRPQTEPFSYPVLEW----EDIKFEDVIGEGNFGQVIKAMIKKDGQK---MNAA 858

  Fly   804 VKMLKKGSNSVEYMALLSEFQLLQEVS-HPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSR 867
            :||||:.::..::.....|.::|.::. |||:|.|||||.:.....:.||||.||:|..:||.||
Frog   859 IKMLKEFASENDHRDFAGELEVLCKLGHHPNIINLLGACENRGYLYIAIEYAPYGNLLDFLRKSR 923

  Fly   868 KIECAGVDFADGVEPVNVK-----------MVLTFAWQICKGMAYLSELKLVHRDLAARNVLLAD 921
            .:|         .:||..|           .:|.||..:.|||.||||.:.:||||||||||:.:
Frog   924 VLE---------TDPVFAKEHGTASTLTSQQLLQFASDVAKGMQYLSEKQFIHRDLAARNVLVGE 979

  Fly   922 GKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGA 986
            ..:.||:||||:|.   ::.|:|::..|:||:|||.|||...|||:||||||||||.||:::||.
Frog   980 NLVTKIADFGLSRG---EEVYVKKTMGRLPVRWMAIESLNYSVYTTKSDVWSFGVLLWEIVSLGG 1041

  Fly   987 SPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAK 1051
            :||.|:....|:..|..||||::|.||.:.||.::|.||.|.|..||.|..::.:..::|.....
Frog  1042 TPYCGMTCAELYENLPQGYRMEKPRNCDDEVYELMRQCWRDRPYERPPFSQISIQLTRMLDARKA 1106

  Fly  1052 YIDLETNAVSNPLYCGDDS 1070
            |:::.  ...|..|.|.|:
Frog  1107 YVNMA--LFENFTYAGIDA 1123

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.