Protein Alignment Ret and LOC100496572

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: NP_001415012.1
• Gene: LOC100496572 / 100496572
• XenbaseID: XB-GENE-29083231
• Length: 1368
• Species: Xenopus tropicalis
• Alignment Length: 1357
• Identity: 293/1357 - (21%)
• Similarity: 479/1357 - (35%)
• Gaps: 413/1357 - (30%)

  Fly    10 TLLTIITQRKHCAAVDVYFPTTSVKFNMPINEESESIFSKIPLAQFQVLRMEDNRLASDYLYSLE 74
            |||:::||.:     .|||.|.|     .::......:|...::..::|..:|.  .|...:||.
 Frog   170 TLLSVVTQSR-----GVYFYTAS-----SLDSRIAESYSPTSISIRRLLGSQDG--FSPGFHSLS 222

  Fly    75 QNPLLRINSSSGEI-YMRTDYRSPNSSATFLVTAFPRDQPDHELLNVSH---LSLEVTPQPLEEY 135
               :|.....|..| |:.|   ..:.|..:.:|.    ||:|.|.|..|   :.|....:.:..|
 Frog   223 ---VLESYRDSYPIHYVHT---FVSGSYVYFLTV----QPEHPLSNTYHSRVVRLSKNEEEMRSY 277

  Fly   136 ------CSELE---------------------HICFWSS---AQYTIAESHGPYRRKDFFEPVLI 170
                  | .||                     |:....|   .:..|:|.          :|||.
 Frog   278 RELILEC-RLEPKRRRRRRRAEPKIFNVLKAAHVATVGSTLAGELDISEK----------DPVLF 331

  Fly   171 GALNSRAAKYLCPH--------------VSLEYSLNA------------GSSHF------VLKQN 203
            ........|...|.              :|:|..:||            |.:.|      ..|.|
 Frog   332 AVFAQSEPKSAQPRYNSAVCAFPLRLIDLSIEDGMNACCSNTNSVRLTRGLNFFQPEMDCPQKDN 396

  Fly   204 RLYTR----QTLDHDELNGLNAKAGQLQARITCTVKLSSRDQ-------RKFSRILDIKLLDRND 257
            :..|.    .||....|..::...|||...:..:|.:|.::.       ....|:|.: :|.||.
 Frog   397 QSDTSCKNVPTLVLPPLRRVDIFNGQLDGVLLTSVYVSPQEDLTIGFLGTSAGRLLQV-VLQRNS 460

  Fly   258 NGPKLQESSSKFDFYLEQPYFQADEEAGKKVIYVDKDTLEANAHLVYAVHNDSHGLFRPDC-HAY 321
            | |:...:.|..|.|   |..:...:.|..:.:|       ..:.|..|:     :..|.| |..
 Frog   461 N-PRTLSNFSISDNY---PVSREVTQIGDSLFFV-------TGNQVTKVN-----ITGPGCRHFL 509

  Fly   322 EADHTGRPHTIVSCQLRFSRNGVFRETPYCVSLEARDLTIVSRVDAMSATANVCYHINLSKLHES 386
            ......|....:.|.  :.:| |..:...|....|::..:.:..|....||.:..:.|::.....
 Frog   510 TCSRCLRAPRFMGCS--WCKN-VCCQQGECEGECAQNTCLPAITDFYPKTAPLRGNTNITLCGRD 571

  Fly   387 EQ-----ELPQALPLRARQHRIFESEEFNGDSAGRSLSPPTVDYDKDVSVYRSAASNFRVVQPDS 446
            .|     ..|....:.|..||:             |:.|.|...:...|   ::.|....:|.:.
 Frog   572 FQSSVVYNAPPKAKITAGTHRV-------------SVGPRTCIVNPGKS---NSTSLVCTLQTEG 620

  Fly   447 FLDLMRLRSIRFDIVEDKLGA----FGITSTSGIVFVKNPQVLEEAPE----------TIYFLNV 497
            ..|......|...|.|:..|.    .|..|.:|..||: |.:....|.          |:...|:
 Frog   621 LPDTASTADIALTIDENLTGTPYYIKGTISAAGFNFVE-PAITSIEPNFGPLAGGTMLTLKGQNL 684

  Fly   498 TWIDQQRLSHVRVINVHLVHGR---------PENTSCELKVKSRS---------------QTCAQ 538
            ...:.||:         .:.|.         |....|.:..:|.|               .:.||
 Frog   685 RSGETQRV---------FISGAECMISGSLCPAEVLCCVSPRSLSLGPLNVSALLDGAEISSPAQ 740

  Fly   539 IKY---------QSQC----------------------VRYCGLATGGGSCQWRGSNSAM----- 567
            .:|         :..|                      :.|.|..|....||...|:..:
 Frog   741 FQYKPDPLVSVIRPNCSLASGTRLTIQGSNLDSVSSIKISYSGQKTVSSDCQGTFSSDRIVCRSP 805

  Fly   568 ----FGTRYGSCV----------P-ESRYCPDHVCDPLEELNPMACPQDCTPAGRIV----GP-- 611
                || |.|:..          | ..||..::|..|..       |:|  |.|.|:    |.
 Frog   806 EYPYFG-RPGNLTLALDAVNYIYPYRFRYLQNYVIHPFR-------PKD--PDGGILKLKKGEDE 860

  Fly   612 -HSSNENKRGIYSASGTCICEDNGKCSCAPLDEEPKMKKPRKRKNETEA---------------- 659
             .:..||...:.:.....:.....:|:...|..|...:.|:.....:|.
 Frog   861 IETHQENLEQVATCLKVSMTVGGRECNPTVLKNEITCRIPKGMVIPSEGSIVQVCVDDDCTTVGL 925

  Fly   660 -------EPLLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQ 717
                   :|:||:..|:                               ...:|.|.:|:.||:..
 Frog   926 VMIVNMLDPVLGIVLGS-------------------------------VASVLVVAVLIFLLLKH 959

  Fly   718 RKMLQRRLGKQSMTTSSK-------------------QALPES-----------------GGGDF 746
            ::..:::...:::...|.                   ..:|.|                 |||..
 Frog   960 QRKKKKKPAVEALELLSNNNREPVLSPISLLHVDYRTSYIPSSNSGGMLSHGAGYSGGSLGGGSM 1024

  Fly   747 ALM------PLQSGFRFESGDAKWEFPREKL--QLDTVLGEGEFGQVLKGFATEIAGLPGITTVA 803
            .::      .|:.....|..|..  .|...|  ..|.::|:|.||.|..|  |.:.........|
 Frog  1025 PILLTSLLDSLRPELLEEVKDVL--IPERCLTTHRDRIIGKGHFGSVYHG--TYVDEDQQEVHCA 1085

  Fly   804 VKMLKKGSNSVEYMALLSEFQLLQEVSHPNVIKLLGACTSSEA-PLLIIEYARYGSLRSYLRLSR 867
            ||.|.:.::..|....|.|..|::...||||:.|:|.....|. ||:::.:.::|.||.::|...
 Frog  1086 VKSLNRITDLEEVEEFLREGILMKSFHHPNVLSLIGIFLPQEGLPLVVLPFMKHGDLRHFIRCQE 1150

  Fly   868 KIECAGVDFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGL 932
            :            .| .||.::.|..|:.:||.||:..|.|||||||||.:|.:....|::||||
 Frog  1151 R------------NP-TVKDLVGFGLQVSRGMEYLANRKFVHRDLAARNCMLDETFHVKVADFGL 1202

  Fly   933 TRDVYEDDAY-LKRSRD-RVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQ 995
            .|||::.:.| ::|.:: |:||||||.|||....:|:||||||||||.|||:|.||.|||.:.|.
 Frog  1203 ARDVFDKEYYSVRRHKNARLPVKWMALESLQTQKFTTKSDVWSFGVLLWELMTRGAPPYPDVDPY 1267

  Fly   996 NLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAV 1060
            ::...|..|.|:.:||.|.:.:||::.:||..:|..||:|..|..:.|               .:
 Frog  1268 DITRYLFRGRRLAQPEYCPDPLYSLMLSCWNPQPEERPTFTQLVGDME---------------VI 1317

  Fly  1061 SNPLYCGD-----DSALITTELGEPESLQHLWSPPKIAYDIHDQATSYDQSEEEMPV 1112
            ||.| |||     :...:..:..:|....|   ||. ..::.::.:|.:  |||.|:
 Frog  1318 SNSL-CGDHYINLNVTYVNLDRDQPFPPTH---PPS-EDELEEENSSTE--EEENPI 1367

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	107/283 (38%)
LOC100496572	NP_001415012.1	None