Protein Alignment Ret and ret

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_012822323.2
• Gene: ret / 100495902
• XenbaseID: XB-GENE-485176
• Length: 1102
• Species: Xenopus tropicalis
• Alignment Length: 1270
• Identity: 376/1270 - (29%)
• Similarity: 556/1270 - (43%)
• Gaps: 318/1270 - (25%)

  Fly    23 AVDVYFPTTSVKFNMPINEESESIFSKIPLAQFQVLRMEDN-------RLA-SDYLYSLEQNPLL 79
            |..:||.|.....|:.:::.:.::...|.:       |:|:       ||. :.||..:......
 Frog    17 ASGLYFLTKDYDENLYVDQPAGTLLLHIHV-------MKDSPHETPHFRLCPNSYLSRISFYHWF 74

  Fly    80 RINSSSGEIYM-----RTDYR--SPNSSAT---FLVTAFPRDQP--DHELLNVSHLSLEVTPQPL 132
            .|:..:|.:|:     |:||.  :..||..   .::....:.||  |:...|.....:.:|.:.:
 Frog    75 WIDEHTGILYLNRSLDRSDYEVFAQGSSLAVQKIILKVSTKPQPFLDNNCDNAPFTRVHLTFRNI 139

  Fly   133 -EEYCSEL--EHICF-WSSAQYTIAESHGPYRRKDFFEPVLIGALNSRAAKYLCPHVSLEYSLNA 193
             ...||.|  :.:|| .....:.|.|:..|.:...|         :.|.....||:||:.|.|.:
 Frog   140 TSSICSSLKPKDLCFNDKDLSFHIKENKPPGKLYKF---------HPRPIVQSCPNVSVSYMLIS 195

  Fly   194 GSSH---FVLKQNRLYTRQTLDHDELNGLNAKAGQLQARITCTVKLSSRDQRKFSRILDIKLLDR 255
            ..|:   |....:.:....|:|.:|....:..|       .|.:: .|..:.:..:...||:.|.
 Frog   196 DHSYPFRFNPNTSEVSLTHTMDREERENYDLVA-------KCLLR-DSTSEVEVEKSFQIKVDDE 252

  Fly   256 NDNGPKLQESSSKFDFYLE-------------------QPYFQAD---EEAGKKVIYVDKDTLEA 298
            :|..|.|...:...:..:|                   .|.:.|:   ::..|.::..|:..||
 Frog   253 DDTAPFLPNGTDTANVVVEFKRKNGTVLGMLTVWDADSTPVYPAEASFKKYAKTIVNNDRFILE- 316

  Fly   299 NAHLVYAVH----NDSHGLFRPDCHAYEADHTGRPHTIVSCQLRFSRNGVFRETPYCVSLEARDL 359
            |..:.::..    .....|.|...|.|        ..:::..:..:|||     ...||:
 Frog   317 NFRVEHSFREVKFQPKGNLIRGTLHEY--------RLVLNKTMPITRNG-----SLLVSV----- 363

  Fly   360 TIVSRVDAMSATANVCYHINLSKLHESEQELPQALPLRARQHRIFESEEFNGDSAGRSLSPPTVD 424
             :|:..:......:|..:.|::           .||:..|.                    |.:.
 Frog   364 -LVNDTEFHGPNGDVMLYFNVT-----------ILPVEIRF--------------------PNIS 396

  Fly   425 YDKDVS------------------VYRSAASNFRVVQPDSFLDLMRLRSIRFDIVEDKLGAFGIT 471
            |...|:                  ::.....|:| :|.|:       .:..|.|::      |..
 Frog   397 YQYTVNRNADRYAQIEKICIENCKLFEGVNVNYR-LQTDN-------NTRAFSIIQ------GRE 447

  Fly   472 STSGIVFVKNPQVL--EEAPETIYFLNVTWIDQQRLSHVRVINVHLVHGRP--ENTSCELKVKSR 532
            ||...:.|.:...|  .|:.|.:..:..|  ::.....|:...:.::.|.|  ...:|
 Frog   448 STFATLIVNDSDALATHESKEVVCTVFAT--NKHLKEPVKTQIIIVLEGTPLKNEDNC------- 503

  Fly   533 SQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYGSCVPESRYCPDHVCDPLEELNPMA 597
            .::|::.|.:|:|....||.:..|.||||..:.....|.|.:|.|....|||.|||.:|..|...
 Frog   504 PRSCSESKQKSECEECGGLGSLTGRCQWRQGHGEGITTNYSTCTPSLLTCPDGVCDAVESNNSTI 568

  Fly   598 CPQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSCAPLDEEPKMKKPRKRKNETEAEPL 662
            ||||||....|:|.|.... ..||.:..|||.|....||.|              .||..|.
 Frog   569 CPQDCTTEITIIGGHEKGA-LSGIKAGYGTCFCLLPDKCFC--------------EKNIVEG--- 615

  Fly   663 LGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLL------------- 714
                       ||               ||.:|. .||.|.:....::..||
 Frog   616 -----------PL---------------CDDTCK-TVIACGVFLSFIISVLLSSYFIHRYHKNSP 653

  Fly   715 ---IAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMP-LQS--------GFRFESGDAKWEFP 767
               ||..:|..||         ..|:.|.|...:.|..| |.|        .|:... |.|||||
 Frog   654 KPPIASAEMTFRR---------PAQSYPVSYSSNNARRPSLDSMENQVSVDTFKIPE-DPKWEFP 708

  Fly   768 REKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHP 832
            |:.|.|...|||||||:|:|..|..:.|..|.|||||||||:.::..|...|||||.||::|:||
 Frog   709 RKNLVLGKTLGEGEFGKVVKATAFRLKGKAGYTTVAVKMLKESASQSELRDLLSEFNLLKQVNHP 773

  Fly   833 NVIKLLGACTSSEAPL-LIIEYARYGSLRSYLRLSRKI--ECAGVD------FADGVEPVNVKM- 887
            :||||.|||| .:.|| ||:|||:||||||:||.|||:  ...|.|      :.|..:...:.|
 Frog   774 HVIKLYGACT-QDGPLHLIVEYAKYGSLRSFLRESRKVGPSSLGGDSNRNSSYLDNPDERALTMG 837

  Fly   888 -VLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVP 951
             :::|||||.:||.||:|:|||||||||||||:|:|:..|||||||:|||||:|:|:|||:.|:|
 Frog   838 DLISFAWQISRGMQYLAEMKLVHRDLAARNVLVAEGRKMKISDFGLSRDVYEEDSYVKRSKGRIP 902

  Fly   952 VKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEA 1016
            |||||.|||.||:||::|||||||||.||::|||.:|||||||:.|::||||||||::|||||:.
 Frog   903 VKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIAPERLFNLLKTGYRMEKPENCSDE 967

  Fly  1017 VYSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAVSNPLYCGDDSALITTELGE-- 1079
            :|:::..||..||:.||:|..::.|.||::..:..|:||   |.|.|.    ||.|....|.|
 Frog   968 MYNLMLKCWKQEPDKRPTFGEISKELEKMMVKSRDYLDL---AASTPA----DSLLYDDGLSEEE 1025

  Fly  1080 -----------PESLQHLWSPPKIAYDIHDQATSYDQSEEEMPVTSTAPPGYDLPRPLLDATANG 1133
                       |.:|...|...|:      ...||....||.||          |.|..|  ||.
 Frog  1026 TPLVDCNNAPLPRTLPSTWIENKL------YGMSYPNWSEESPV----------PIPRFD--ANK 1072

  Fly  1134 QVL-RYENDLRFPLNIRKSSCTPSYSNMTSEPPAT 1167
            .|. ||.||           |.  |:|... ||:|
 Frog  1073 SVFSRYAND-----------CV--YANWMI-PPST 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	166/289 (57%)
ret	XP_012822323.2	RET_CLD1	20..140	CDD:465485	24/126 (19%)
		CA_like	160..242	CDD:481204	19/98 (19%)
		RET_CLD3	252..368	CDD:465516	21/135 (16%)
		RET_CLD4	392..494	CDD:465517	18/137 (13%)
		PTKc_RET	711..1000	CDD:173631	166/289 (57%)