Protein Alignment Ret and ret

DIOPT Version :9

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_012822323.2
• Gene: ret / 100495902
• XenbaseID: XB-GENE-485176
• Length: 1102
• Species: Xenopus tropicalis
• Alignment Length: 1269
• Identity: 373/1269 - (29%)
• Similarity: 553/1269 - (43%)
• Gaps: 316/1269 - (24%)

  Fly    23 AVDVYFPTTSVKFNMPINEESESIFSKIPLAQFQVLRMEDN-------RLA-SDYLYSLEQNPLL 79
            |..:||.|.....|:.:::.:.::...|.:       |:|:       ||. :.||..:......
 Frog    17 ASGLYFLTKDYDENLYVDQPAGTLLLHIHV-------MKDSPHETPHFRLCPNSYLSRISFYHWF 74

  Fly    80 RINSSSGEIYM-----RTDYR--SPNSSAT---FLVTAFPRDQP--DHELLNVSHLSLEVTPQPL 132
            .|:..:|.:|:     |:||.  :..||..   .::....:.||  |:...|.....:.:|.:.:
 Frog    75 WIDEHTGILYLNRSLDRSDYEVFAQGSSLAVQKIILKVSTKPQPFLDNNCDNAPFTRVHLTFRNI 139

  Fly   133 -EEYCSEL--EHICF-WSSAQYTIAESHGPYRRKDFFEPVLIGALNSRAAKYLCPHVSLEYSLNA 193
             ...||.|  :.:|| .....:.|.|:..|.:...|         :.|.....||:||:.|.|.:
 Frog   140 TSSICSSLKPKDLCFNDKDLSFHIKENKPPGKLYKF---------HPRPIVQSCPNVSVSYMLIS 195

  Fly   194 GSSH---FVLKQNRLYTRQTLDHDELNGLNAKAGQLQARITCTVKLSSRDQRKFSRILDIKLLDR 255
            ..|:   |....:.:....|:|.:|....:..|       .|.:: .|..:.:..:...||:.|.
 Frog   196 DHSYPFRFNPNTSEVSLTHTMDREERENYDLVA-------KCLLR-DSTSEVEVEKSFQIKVDDE 252

  Fly   256 NDNGPKLQESSSKFDFYLE-------------------QPYFQAD---EEAGKKVIYVDKDTLEA 298
            :|..|.|...:...:..:|                   .|.:.|:   ::..|.::..|:..||
 Frog   253 DDTAPFLPNGTDTANVVVEFKRKNGTVLGMLTVWDADSTPVYPAEASFKKYAKTIVNNDRFILE- 316

  Fly   299 NAHLVYAVH----NDSHGLFRPDCHAYEADHTGRPHTIVSCQLRFSRNGVFRETPYCVSLEARDL 359
            |..:.::..    .....|.|...|.|        ..:::..:..:|||     ...||:
 Frog   317 NFRVEHSFREVKFQPKGNLIRGTLHEY--------RLVLNKTMPITRNG-----SLLVSV----- 363

  Fly   360 TIVSRVDAMSATANVCYHINLSKLHESEQELPQALPLRARQHRIFESEEFNGDSAGRSLSPPTVD 424
             :|:..:......:|..:.|::           .||:..|.                    |.:.
 Frog   364 -LVNDTEFHGPNGDVMLYFNVT-----------ILPVEIRF--------------------PNIS 396

  Fly   425 YDKDVS------------------VYRSAASNFRVVQPDSFLDLMRLRSIRFDIVEDKLGAFGIT 471
            |...|:                  ::.....|:| :|.|:       .:..|.|::      |..
 Frog   397 YQYTVNRNADRYAQIEKICIENCKLFEGVNVNYR-LQTDN-------NTRAFSIIQ------GRE 447

  Fly   472 STSGIVFVKNPQVL--EEAPETIYFLNVTWIDQQRLSHVRVINVHLVHGRP--ENTSCELKVKSR 532
            ||...:.|.:...|  .|:.|.:..:..|  ::.....|:...:.::.|.|  ...:|
 Frog   448 STFATLIVNDSDALATHESKEVVCTVFAT--NKHLKEPVKTQIIIVLEGTPLKNEDNC------- 503

  Fly   533 SQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYGSCVPESRYCPDHVCDPLEELNPMA 597
            .::|::.|.:|:|....||.:..|.||||..:.....|.|.:|.|....|||.|||.:|..|...
 Frog   504 PRSCSESKQKSECEECGGLGSLTGRCQWRQGHGEGITTNYSTCTPSLLTCPDGVCDAVESNNSTI 568

  Fly   598 CPQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSCAPLDEEPKMKKPRKRKNETEAEPL 662
            ||||||....|:|.|.... ..||.:..|||.|....||.|              .||..|.
 Frog   569 CPQDCTTEITIIGGHEKGA-LSGIKAGYGTCFCLLPDKCFC--------------EKNIVEG--- 615

  Fly   663 LGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLL------------- 714
                       ||               ||.:|. .||.|.:....::..||
 Frog   616 -----------PL---------------CDDTCK-TVIACGVFLSFIISVLLSSYFIHRYHKNSP 653

  Fly   715 ---IAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALMPLQSGFRFESG--------DAKWEFPR 768
               ||..:|..||         ..|:.|.|...:.|..|.......:..        |.||||||
 Frog   654 KPPIASAEMTFRR---------PAQSYPVSYSSNNARRPSLDSMENQVSVDTFKIPEDPKWEFPR 709

  Fly   769 EKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPN 833
            :.|.|...|||||||:|:|..|..:.|..|.|||||||||:.::..|...|||||.||::|:||:
 Frog   710 KNLVLGKTLGEGEFGKVVKATAFRLKGKAGYTTVAVKMLKESASQSELRDLLSEFNLLKQVNHPH 774

  Fly   834 VIKLLGACTSSEAPL-LIIEYARYGSLRSYLRLSRKI--ECAGVD------FADGVEPVNVKM-- 887
            ||||.|||| .:.|| ||:|||:||||||:||.|||:  ...|.|      :.|..:...:.|
 Frog   775 VIKLYGACT-QDGPLHLIVEYAKYGSLRSFLRESRKVGPSSLGGDSNRNSSYLDNPDERALTMGD 838

  Fly   888 VLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPV 952
            :::|||||.:||.||:|:|||||||||||||:|:|:..|||||||:|||||:|:|:|||:.|:||
 Frog   839 LISFAWQISRGMQYLAEMKLVHRDLAARNVLVAEGRKMKISDFGLSRDVYEEDSYVKRSKGRIPV 903

  Fly   953 KWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAV 1017
            ||||.|||.||:||::|||||||||.||::|||.:|||||||:.|::||||||||::|||||:.:
 Frog   904 KWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIAPERLFNLLKTGYRMEKPENCSDEM 968

  Fly  1018 YSIVRTCWADEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAVSNPLYCGDDSALITTELGE--- 1079
            |:::..||..||:.||:|..::.|.||::..:..|:||   |.|.|.    ||.|....|.|
 Frog   969 YNLMLKCWKQEPDKRPTFGEISKELEKMMVKSRDYLDL---AASTPA----DSLLYDDGLSEEET 1026

  Fly  1080 ----------PESLQHLWSPPKIAYDIHDQATSYDQSEEEMPVTSTAPPGYDLPRPLLDATANGQ 1134
                      |.:|...|...|:      ...||....||.||          |.|..|  ||..
 Frog  1027 PLVDCNNAPLPRTLPSTWIENKL------YGMSYPNWSEESPV----------PIPRFD--ANKS 1073

  Fly  1135 VL-RYENDLRFPLNIRKSSCTPSYSNMTSEPPAT 1167
            |. ||.||           |.  |:|... ||:|
 Frog  1074 VFSRYAND-----------CV--YANWMI-PPST 1093

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	166/289 (57%)
		TyrKc	771..1042	CDD:197581	163/281 (58%)
ret	XP_012822323.2	RET_CLD1	20..141	CDD:407628	24/127 (19%)
		Cadherin	160..242	CDD:421759	19/98 (19%)
		RET_CLD3	252..368	CDD:407681	21/135 (16%)
		RET_CLD4	392..494	CDD:407682	18/137 (13%)
		PTKc_RET	711..1000	CDD:173631	166/289 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	326	1.000	Domainoid score	I1190
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D153428at2759
OrthoFinder	1	1.000	-	-		FOG0008389
OrthoInspector	1	1.000	-	-		oto102327
Panther	1	1.100	-	-	LDO	PTHR24416
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X6379
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.020