DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ret and abl1

DIOPT Version :10

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:XP_002936228.2 Gene:abl1 / 100490771 XenbaseID:XB-GENE-6054675 Length:1128 Species:Xenopus tropicalis


Alignment Length:450 Identity:142/450 - (31%)
Similarity:209/450 - (46%) Gaps:78/450 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   763 KWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQ 827
            |||..|..:.:...||.|::|:|.:|...:..     .|||||.||:.:..||  ..|.|..:::
 Frog   261 KWEIERTDITMKHKLGGGQYGEVYEGVWKKYN-----LTVAVKTLKEDTMEVE--EFLKEAAVMK 318

  Fly   828 EVSHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFA 892
            ||.|||:::|||.||......:|.|:..||:|..|||...:.|...|            ::|..|
 Frog   319 EVKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRDCNRQEVTAV------------VLLHMA 371

  Fly   893 WQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAP 957
            .||...|.||.:...:||||||||.|:.:..:.|::||||:| :...|.|...:..:.|:||.||
 Frog   372 TQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSR-LMTGDTYTAHAGAKFPIKWTAP 435

  Fly   958 ESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVR 1022
            ||||.:.::.|||||:||||.||:.|.|.||||||....::.||:..|||:|||.|.|.||.::|
 Frog   436 ESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELMR 500

  Fly  1023 TCWADEPNGRPSFKFLASEFEKLLGNNAKYIDLETNAVSNPLYCGDDSALITTELGE---PESLQ 1084
            .||...|..||||..:..:||.:         .:.:::|:.         :..|||:   ..::.
 Frog   501 ECWQWSPLDRPSFAEIHQDFETM---------FQESSISDE---------VEKELGKKGLKVTVS 547

  Fly  1085 HLWSPPKIAYDIHDQATSYDQSEEEMP----VTSTAPPGYDLPRPLLDATANGQVLRYENDLRF- 1144
            :|...|                  |:|    :|...|...|.........|.|::..:|.:... 
 Frog   548 NLLQAP------------------ELPTKTRITRRVPESKDENAETASVRAAGELDVFEPESAVS 594

  Fly  1145 PLNIRK-----SSCTPSYSNMTSEPPATT---------SLPHYSVPVKRGRSYLDMTNKS 1190
            ||..||     ....|....:..:...|.         ...:...|.||..|:.||...|
 Frog   595 PLLPRKERGAGDGVLPDDDRLLPKDKKTNLFFSTLIKRKKKNAPTPPKRSSSFRDMEGHS 654

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 Protein Kinases, catalytic domain 770..1049 CDD:473864 111/278 (40%)
abl1XP_002936228.2 SH3_Abl 92..145 CDD:212784
SH2_ABL 150..243 CDD:198189
PTKc_Abl 262..524 CDD:270645 114/290 (39%)
F_actin_bind 1003..1128 CDD:471692
Blue background indicates that the domain is not in the aligned region.

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