Protein Alignment Ret and fes

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_002932286.2
• Gene: fes / 100489191
• XenbaseID: XB-GENE-6067138
• Length: 822
• Species: Xenopus tropicalis
• Alignment Length: 903
• Identity: 215/903 - (23%)
• Similarity: 355/903 - (39%)
• Gaps: 219/903 - (24%)

  Fly   211 LDHDELNGLNAKAGQLQ---ARITCTVKLSSRDQRKFSRILD------IKLLDRNDNGPKLQESS 266
            |||....||:....||.   |.:....:..|:..||.|..|:      :.:|.|...  :|::|.
 Frog    58 LDHSPTPGLSEYTSQLNESWATLVSQTENLSQILRKHSEDLNSGPLNKLTILIREKQ--QLKKSY 120

  Fly   267 SKFDFYLEQPYFQADEEAGKKV--IYVD--KDTLEANAHLVYAVHNDSHGLFRPDCHAYEADHTG 327
            |:....|.|.|.:..::..:|:  .|..  |:||:            |...::..|...:.|...
 Frog   121 SEQWQLLNQDYIKTTQQDIEKLRSQYRSQVKETLQ------------SKRKYQEACRDKDRDKAK 173

  Fly   328 RPHTIVSCQLRFSRNGVFRETPYCVSLEARDLTIVSRVDAMSATANVCYH-----INLSKLHESE 387
            ..:...:.:|....|      .|.::::|..|                :|     .:|..||||.
 Frog   174 EKYVKNTWKLHALHN------QYVLAVKAAQL----------------HHEHHFLYSLPTLHESM 216

  Fly   388 QELPQALPLRARQHRIFESEEFNG-------------DSAGRSLSPPTVDYDKDVSVYRSAASNF 439
            |.:.|.: ::..::.:.|..|...             .||..|:| |..:||..:.:.||.:...
 Frog   217 QSIHQEM-VQILKNIMQEYSEITSLVQEEVASLHREIASAVNSIS-PFKEYDNFLQMNRSVSELP 279

  Fly   440 RVVQPDSFL-----DL--------MRLRSIRFDI--VEDKLGAF--GITSTSGIVFVKNPQVLEE 487
            .:|..|:.|     ||        :.:.|::..:  ||::|.:.  .|.....||......:..|
 Frog   280 PIVTFDTSLLEETDDLEEELQLNDLTVESVQHTLTSVEEELASVTAAIEGKQDIVKQLRSDIATE 344

  Fly   488 APETIYFLNVTWI-------DQQRLSHVRVINVHLVHGRPENTSCELKVKSRSQT--------CA 537
            ...|.....:..:       |.....|:.:.|.:.:||:.|      |:|.:..|        ..
 Frog   345 ERTTDCREKINLLAKRHALRDALLQYHMTLCNKNKIHGQRE------KLKRKMNTIGSGDPPPAL 403

  Fly   538 QIKYQSQCV----RYCGLATGGGSCQWRGSNSAMFGTRYGSCVPESRYCPDHVCDPLEELNPMAC 598
            |::..:|.:    |.||..|....   :...|.:|..:: |..|.....|| |..||.:.|   .
 Frog   404 QLQDDNQSISSVERECGKKTLENI---KNHISGIFRPKF-SLPPLLPLIPD-VQKPLSQQN---W 460

  Fly   599 PQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSCAPLDEEPKMKKPRKRKNETEAEPLL 663
            .....|...:.|                  :..:||....              |:::.:.|.:|
 Frog   461 YHGAIPRSEVQG------------------LLVNNGDFLI--------------RESQGKQEYVL 493

  Fly   664 GVR-RGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGK 727
            .|. .|.|.:..:|:......|...||.          |.|||....|..              |
 Frog   494 SVLWEGQPRHFIIQNVDNCYRLEGEGFS----------TIPLLIDHFLKT--------------K 534

  Fly   728 QSMTTSSKQALPESGGGDFALMPLQSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATE 792
            |::|..|...|.::...|                 ||....|::.|...:|:|.||:|..|...
 Frog   535 QAVTKKSGVILNKAVVKD-----------------KWVLEHEEVILGERIGKGNFGEVFSGRLR- 581

  Fly   793 IAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPNVIKLLGACTSSEAPLLIIEYARYG 857
                ...|.||||..:...........|.|.::|::.||||::||:|.||......:::|..:.|
 Frog   582 ----ADNTPVAVKSCRDTLPPDLKDKFLMEARILKQYSHPNIVKLIGVCTQKHPIYIVMELVQGG 642

  Fly   858 SLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADG 922
            ..:::||            .:|.: :.||.::..:.....||.||.....:||||||||.|:.:.
 Frog   643 DFQTFLR------------NEGPK-LKVKELIRMSENAAAGMEYLESKHCIHRDLAARNCLVTEK 694

  Fly   923 KICKISDFGLTRD----VYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELIT 983
            .:.||||||::|:    ||.....:|    ::||||.|||:|....|:|:|||||||||.||..:
 Frog   695 NVLKISDFGMSREEEDGVYSSTGGMK----QIPVKWTAPEALNYGRYSSESDVWSFGVLLWEAFS 755

  Fly   984 LGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASE 1041
            ||:.||..::.|....:::.|.|:..|:||.:.|||::..||..:|..||:|..:..|
 Frog   756 LGSVPYATMSNQQTREIIEQGIRLLVPDNCPDEVYSLMLRCWEYDPKKRPNFSTVHQE 813

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	95/276 (34%)
fes	XP_002932286.2	F-BAR_Fes	7..243	CDD:153369	44/221 (20%)
		SH2_Fps_family	453..537	CDD:198224	24/142 (17%)
		PTKc_Fes	564..815	CDD:270667	94/272 (35%)