Protein Alignment Ret and fgfr3

DIOPT Version :9

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_012812743.1
• Gene: fgfr3 / 100196923
• XenbaseID: XB-GENE-479255
• Length: 829
• Species: Xenopus tropicalis
• Alignment Length: 616
• Identity: 192/616 - (31%)
• Similarity: 282/616 - (45%)
• Gaps: 126/616 - (20%)

  Fly   574 SCVPESRY---CPDHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCI-----C 630
            :||.|::|   ...:..|.||..:.....|...||.:.|...|..|....:||.:...|     .
 Frog   243 TCVVENKYGSIRQTYQLDVLERSSHRPILQAGLPANQTVVIGSDVEFHCKVYSDAQPHIQWLKHV 307

  Fly   631 EDNGKCSCAPLDEEPKMKKPRKRKNETEAEPLLGVRRGTPPN----------------------- 672
            |.||. ...| |.:|.:...:...|.||.:..|.::..|..:
 Frog   308 EVNGS-KYGP-DGDPYVTVLQSFTNGTEVDTTLSLKNVTETHEGQYVCRANNFIGVAEASFWLHI 370

  Fly   673 ------QPLQDP---------MLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQR---- 718
                  :|::.|         :|:.|..:.||                  :||:.:.:..|
 Frog   371 YKPASAEPVEKPTTTSSSSTTVLIVVSVITGF------------------ILLVIIFVTYRVKVP 417

  Fly   719 -----------KMLQRRLGKQSMTTSSKQA------------LPESGGGDFAL-----MPLQSGF 755
                       |:.:..|.:|.::..|..:            |..|.|...|.     :||
 Frog   418 SKKAMSAPPVHKVSKFPLKRQQVSLESNSSMNSNTPLVRITHLSSSDGTMLANVSELGLPL---- 478

  Fly   756 RFESGDAKWEFPREKLQLDTVLGEGEFGQVLK----GFATEIAGLPGITTVAVKMLKKGSNSVEY 816
                 |.|||..|.:|.|...||||.||||:.    |...|....|  .||||||||..:...:.
 Frog   479 -----DPKWELLRTRLTLGKPLGEGCFGQVVMAEAIGIEKERPNKP--VTVAVKMLKDDATDKDL 536

  Fly   817 MALLSEFQLLQEV-SHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECAGVDFADG- 879
            ..|:||.::::.: .|.|:|.||||||......:::|||..|:||.||:..|.   .|:|::..
 Frog   537 SDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVLVEYASKGNLREYLKARRP---PGMDYSFDT 598

  Fly   880 ----VEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDD 940
                .|.:..|.:::.|:|:.:||.||:..|.:||||||||||:.|..:.||:||||.||::..|
 Frog   599 CKIPAEQLTFKDLVSCAYQVARGMEYLASQKCIHRDLAARNVLVTDDNVMKIADFGLARDIHNID 663

  Fly   941 AYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGY 1005
            .|.|.:..|:||||||||:|.|.:||.:|||||:|||.||..|||.||||||..:.|:.|||.|:
 Frog   664 YYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSYGVLLWETFTLGGSPYPGIPVEELFKLLKEGH 728

  Fly  1006 RMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLL--GNNAKYIDLETNAVSNPLYCGD 1068
            |||:|.||:..:|.|:|.||...|:.||:||.|..:.:::|  .:..:|:||..........|.|
 Frog   729 RMDKPANCTHELYMIMRECWHAVPSQRPTFKQLVEDLDRVLTVTSTDEYLDLSVPFEQYSPACQD 793

  Fly  1069 DSALITTELGEPESLQHLWSPPKIAYDIHDQ 1099
            ..:  |...|:.....|...|.:.....|.|
 Frog   794 SHS--TCSSGDDSVFAHDILPDEPCLPKHQQ 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	130/290 (45%)
		TyrKc	771..1042	CDD:197581	129/280 (46%)
fgfr3	XP_012812743.1	IGc2	74..129	CDD:197706
		Ig2_FGFR	177..261	CDD:143265	4/17 (24%)
		Ig3_FGFR	284..371	CDD:319280	16/88 (18%)
		PTKc_FGFR3	476..809	CDD:173652	144/348 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910