Protein Alignment Ret and mst1rb

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_073773053.1
• Gene: mst1rb / 100134855
• ZFINID: ZDB-GENE-071218-3
• Length: 1374
• Species: Danio rerio
• Alignment Length: 886
• Identity: 211/886 - (23%)
• Similarity: 324/886 - (36%)
• Gaps: 275/886 - (31%)

  Fly   375 CYHINLSKLHESEQE-LPQALPLRARQHRIFESEEFNGDSAGRSLSPPTVDYDKDVSVYRSAASN 438
            |.|: |.|:.....| |.:.|.:.|:.|        .|...|..    ::|...::..:.....|
Zfish   610 CTHL-LCKIRSGTIETLFKPLNVTAKVH--------EGQVEGHY----SIDGSAEMPGFTFVVPN 661

  Fly   439 FRVVQPD--------------SFLDLMRLRSIRFD----------IVEDKLGAF-----GITSTS 474
            ...||||              .:||..:.|.:..|          :....|.:.     .:|...
Zfish   662 ITEVQPDYGPVDGGTLITITGPYLDSGKNRKVTLDGESCPVQSVSVARGNLSSIVCLSQPVTEVK 726

  Fly   475 GIV-----------------FVKNPQVLEEAPE----------------------TIYFLNVTWI 500
            .:|                 :.|.|::|...|:                      .:||
Zfish   727 DVVLRVYIDKSRVVTTKVFRYKKTPEILAVLPDCSFDSGSRIIIEGRNLDSVYRTVVYF------ 785

  Fly   501 DQQRLSHVRVINVHLVHGRPENTSCELKVKSRSQTC------------AQIKYQSQCVRYCGLAT 553
             |.:.||:          :|.:|.|..|.|.....|            .::.:....|  .||
Zfish   786 -QPKESHL----------KPVSTECRGKAKPTRMECITPVFPRDETEEGELSFDMDGV--LGL-- 835

  Fly   554 GGGSCQWRGSNSAMFGTRYGSCVPES------RYCP--DHVCDPLEELNPMACPQDCTPAGRIVG 610
                  |:...|.   ..||..:|..      |..|  |.|....::||.::   .|......||
Zfish   836 ------WKHDFSY---HPYGRPIPFETEGHILRLYPGFDEVSLHHQKLNLVS---SCMSITMTVG 888

  Fly   611 PHSSNENKRGIYSASGTCICEDNGKCSCAPLDEEPKMKKPRKRKNETEAEPLLGVRRGTPPN--- 672
                                  :..|....||.|...:.|......:|..|:.....|...|
Zfish   889 ----------------------DVDCGGKVLDNEITCRIPNNLTIPSEGLPVKVTVNGYTHNVGT 931

  Fly   673 -----QPLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQ---------- 722
                 ......::||:|..            ::|..:| ..::|..|..|:|..|
Zfish   932 VILVSNHYMVGIVLGILAA------------LVTGAVL-AFIVLKNLRKQKKASQTENRLSYFSH 983

  Fly   723 RRLGKQSMTTSS----KQALP-----------------ESGGGDFALMPLQ-------SGFRFES 759
            .|....|:..||    ::.||                 .:|..|..|.||.       :.||.|.
Zfish   984 SRSRSNSVDLSSLVDYRRDLPLTSITAPTGALAFPGLAYTGTLDTTLTPLMPPENISITSFRPEL 1048

  Fly   760 GDAKWE--FPREKLQL--DTVLGEGEFGQVLKGFAT-----EIAGLPGITTVAVKMLKKGSNSVE 815
            .:...:  .|...|::  ..::|:|.||.|..|:.|     ||       ..|||.|.:.::..|
Zfish  1049 LEEVKDVLIPASTLKVHHHQIIGKGHFGTVYHGYLTDHNNREI-------HCAVKSLNRITDVEE 1106

  Fly   816 YMALLSEFQLLQEVSHPNVIKLLGACTSSEA-PLLIIEYARYGSLRSYLRLSRKIECAGVDFADG 879
            ....|.|..|::...|.||:.|||.....|. ||:::.|.::|.||.::|...:
Zfish  1107 VEQFLKEGILMKGFHHSNVLSLLGILLPEEGLPLVVLPYMKHGDLRHFIRCENR----------- 1160

  Fly   880 VEPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLK 944
             .| .||.::.|..|:.|||.||::.|.|||||||||.:|.:....|::|||:.|||.|.:.|..
Zfish  1161 -NP-TVKDLIGFGLQVAKGMEYLAQKKFVHRDLAARNCMLDESYTVKVADFGMARDVLEKEYYSV 1223

  Fly   945 RS--RDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRM 1007
            :.  :.::||||||.|||....:|:||||||||||.||::|.||||||.:.|.::...|..|.|:
Zfish  1224 QDHRKAKLPVKWMAIESLQTQKFTTKSDVWSFGVLMWEMLTRGASPYPEVDPYDVTHFLLKGRRL 1288

  Fly  1008 DRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGN--NAKYIDLETNAVSNPLYCGDDS 1070
            .:|:.|.:.:::|:..||..:|..||||..|.|....:|.:  ...||.|:...|:
Zfish  1289 PQPQYCPDPLFAILLQCWDPDPEKRPSFSTLVSAVMSILSSLEGEHYISLKVTYVN--------- 1344

  Fly  1071 ALITTELGEPESLQHLWSPPKIAYDIHDQATSYDQSEEEMP 1111
                  |.:|.....|          .|.|..||.|:.:.|
Zfish  1345 ------LDQPRPYPAL----------TDSADEYDSSDADEP 1369

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	108/290 (37%)
mst1rb	XP_073773053.1	None