DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ret and pdgfra

DIOPT Version :9

Sequence 1:NP_477044.1 Gene:Ret / 43875 FlyBaseID:FBgn0011829 Length:1235 Species:Drosophila melanogaster
Sequence 2:NP_001096290.1 Gene:pdgfra / 100124862 XenbaseID:XB-GENE-6072920 Length:1091 Species:Xenopus tropicalis


Alignment Length:672 Identity:187/672 - (27%)
Similarity:291/672 - (43%) Gaps:180/672 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   629 ICEDNGKCSCAPL-------DEEPKMKKPRKRKNETEA-------EPLLGVR------RGTPPNQ 673
            :|:|..:|:...|       ..|..|:..:..:|..|:       |..:.:|      .|....:
 Frog   452 VCKDIKRCNNDTLWSLLAINGSEISMETHQDYENTIESQVTFKKVEETMAIRCIARNDLGVVARE 516

  Fly   674 -PLQDPMLLGVLNVAGFECDRSCMFFVITCPLLFVLLLLCLLIAQRKMLQRRLGKQSMTTSSKQA 737
             .|..|.|...|.||.          .:...|:.|::.|.:|:.        :.||......:..
 Frog   517 LKLVAPTLRSELTVAA----------AVLVLLVIVIISLIVLVI--------IWKQKPRYEIRWR 563

  Fly   738 LPES---GGGDFALM-PLQSGFRFESGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEIAGLPG 798
            :.||   .|.::..: |:|..:     |::|||.|:.|.|..:||.|.||:|::|.|..::....
 Frog   564 VIESISPDGHEYIYVDPMQLPY-----DSRWEFQRDGLVLGRILGSGAFGKVVEGTAYGLSRSQP 623

  Fly   799 ITTVAVKMLKKGSNSVEYMALLSEFQLLQEV-SHPNVIKLLGACTSSEAPLLIIEYARYGSLRSY 862
            :..|||||||..:.|.|..||:||.:::..: :|.|::.||||||.|....:|.||..||.|.:|
 Frog   624 VMKVAVKMLKPTARSSEKQALMSELKIMTHLGAHLNIVNLLGACTKSGPIYIITEYCFYGDLVNY 688

  Fly   863 LRLSR-------------KIECAGV---------------------------------------- 874
            |..:|             .::..|:                                        
 Frog   689 LHKNRDNFQSRHPEKSKKDLDIFGLNPADESTRSYVILSFENNGDYMDMKQADTMQYVPMLEMKE 753

  Fly   875 --------------------------------DFADGVEPVNVKMVLTFAWQICKGMAYLSELKL 907
                                            |..||.:.:.|..:|:|.:|:.:||.:|:....
 Frog   754 PSKYSDIQRSLYDRPASYKKKPLSEVKNILSDDGFDGFDGLTVLDLLSFTYQVARGMEFLASKNC 818

  Fly   908 VHRDLAARNVLLADGKICKISDFGLTRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVW 972
            |||||||||||||.|||.||.||||.||:..|..|:.:....:|||||||||:.|::||:.||||
 Frog   819 VHRDLAARNVLLAHGKIVKICDFGLARDIMHDSNYVSKGSTFLPVKWMAPESIFDNLYTTLSDVW 883

  Fly   973 SFGVLCWELITLGASPYPG-IAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFK 1036
            |||:|.||:.:||.:|||| |.....::.:|:||||.:|::.:..||.|:..||..||..||||:
 Frog   884 SFGILLWEIFSLGGTPYPGMIVDSTFYNKIKSGYRMAKPDHATHEVYDIMVKCWNSEPEKRPSFR 948

  Fly  1037 FLASEFEKLLGNNAK---------YIDLETNAVSNPLYCGDDSALITTELGEPESLQHLWSPPKI 1092
            .|:...|.||....|         ::..:..||:......|:|.:..|...|.:           
 Frog   949 HLSDIVESLLPMEYKRCYETVLHDFLKSDHPAVTRMRSDSDNSYIGVTYKNENK----------- 1002

  Fly  1093 AYDIHDQATSYDQSEEEMPVTSTAPPGYDLPRPLLDATANGQVLRYENDLRFPLNIRKSSCTPSY 1157
               :.|:.:.:|:..      .:|..||.:|.|.:|                |::..:||....:
 Frog  1003 ---MKDRESGFDEQR------LSADSGYIIPLPDID----------------PVSEDESSKRNRH 1042

  Fly  1158 SNMTSEPPATTSLPHYSVPVKR 1179
            |:.|||..|..:....|..:||
 Frog  1043 SSQTSEESAIETGSSSSTFIKR 1064

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RetNP_477044.1 PKc_like 770..1049 CDD:304357 128/365 (35%)
TyrKc 771..1042 CDD:197581 125/357 (35%)
pdgfraNP_001096290.1 Ig_3 29..101 CDD:404760
Ig 215..313 CDD:416386
Ig strand A 215..219 CDD:409353
Ig strand A' 226..230 CDD:409353
Ig strand B 232..241 CDD:409353
Ig strand C 246..251 CDD:409353
Ig strand C' 254..256 CDD:409353
Ig strand D 260..268 CDD:409353
Ig strand E 272..280 CDD:409353
Ig strand F 290..296 CDD:409353
Ig strand G 301..307 CDD:409353
Ig 316..416 CDD:416386
PTKc_PDGFR_alpha 558..960 CDD:173653 138/406 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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