Protein Alignment Ret and mst1ra

DIOPT Version :10

• Sequence 1: NP_477044.1
• Gene: Ret / 43875
• FlyBaseID: FBgn0011829
• Length: 1235
• Species: Drosophila melanogaster
• Sequence 2: XP_005166175.1
• Gene: mst1ra / 100002448
• ZFINID: ZDB-GENE-071218-2
• Length: 1356
• Species: Danio rerio
• Alignment Length: 1270
• Identity: 280/1270 - (22%)
• Similarity: 460/1270 - (36%)
• Gaps: 381/1270 - (30%)

  Fly    12 LTIITQRKHCAAVD----------VYFPTTSVKFNMPINEESESIFSKIPLAQFQV--------- 57
            ||::.:.:....:|          |||.:...:..|..|.:.::...::|:...::
Zfish   225 LTVLPKFQDVFTIDYIYTFSTTEYVYFLSVQWESLMKPNAKLQTHLGRLPIKDSELWMYREIILE 289

  Fly    58 LRMEDNRLA---SDYLYSLEQNPLLRINSSSG-----EIYMRTDYRSPNSSATFLVT-------- 106
            .|.|..|..   .|.:|:..|....   |::|     ::.:|.|  ||.....|.||
Zfish   290 CRFEPKRRRRSFRDVVYNSVQAAHF---STAGKELADDLGVRID--SPILYGVFAVTDQKGNPMR 349

  Fly   107 -----AFPRDQPDHELLNVSHLSLEVTPQPLEEYCSELEH-----ICFWSSAQYTIAESHG---- 157
                 |||.|..:..:           .:.::..||.|..     :|.:...:....|:..
Zfish   350 QSALCAFPLDYVNSAI-----------EKGVDACCSSLTEQISRGLCHFQPCEMCPVENSDSLTC 403

  Fly   158 ---------PYRRKDFFE---------PVLIGALNSRAAKYL---------------CPHVSLEY 189
                     ||.|.|||.         .:|:..:.::...::               .|.|...|
Zfish   404 KTTPTMVSKPYYRVDFFNGQMSNVLFTSILVTTIETKTVAHIGTDHGRLLQIILSRSIPVVFANY 468

  Fly   190 SLNAGSSHFVLKQNRLYTRQTLDHDELNGLNAKAGQLQARITCTVKLSSRDQRKFSRILDIKLLD 254
            ||        ::..:..:|....|..|..|....|.                         ||::
Zfish   469 SL--------VEDAQKVSRIAAIHSSLESLLFVVGN-------------------------KLIN 500

  Fly   255 RNDNGPKLQESSSKF---DFYLEQPYFQADEEAGKKVIYVDKDTLEANAHLVYAVHNDSHGLFRP 316
            .:..||    ..|.|   ...|..|.|......|:                   |.:..|
Zfish   501 VSPRGP----GCSHFLNCSACLAAPRFMGCGWCGE-------------------VCSQQH----- 537

  Fly   317 DCHAYEADHTGR----------PHTIVS--------CQLRF---SRNGVFRETPYCVSLEARDLT 360
            .|   |...:|.          |.|:.|        |...|   ||..:.:|: :.|.:...|.|
Zfish   538 QC---EDQWSGDSCPPVITQFFPRTVPSNGTSELILCGWNFQSASRPAITQES-HQVRVGNSDCT 598

  Fly   361 IVSRVDAMSATANVCYHI-NLSKLHESEQELPQALPLRARQHRIFESEEFNGDSA--GRSLSPPT 422
            :|.  :..|::..||..: ..|.||:|..     :.::..:.:.......:|.:.  |.|...|.
Zfish   599 VVP--EKTSSSLLVCRIVGEESGLHQSVN-----ITIQVNEKKAGSGYFISGKAGIQGFSFVTPE 656

  Fly   423 VDYDKDVS-VYRSAASNFRVVQPDSFLDLMRLRSIRFDIVEDKLGAFGITSTSGIVFVKNPQVLE 486
            :   .|:| .:........:......||....|:|.   :.|:.......|:.|...|...:.::
Zfish   657 I---TDISPSFGPKIGGTLITLSGKHLDAGGSRTIS---LGDRNCPVESVSSDGTSIVCRSEGVK 715

  Fly   487 EAPETIYFLNV-TWIDQQRLSHVRVINVHLVHGRPE----NTSCELKVKSR---------SQTCA 537
            :..|    ::| ..||...:|..:..:..:   .||    |.:|..:..|:         |.:.|
Zfish   716 DTLE----VDVKVVIDGSTISSTKTFSYRV---NPEVTGVNPNCGFRRGSKIIITGQNLDSVSQA 773

  Fly   538 QIKY-------------------QSQCVR-YCGLATGGGSCQWRGSNSAMFGTRYGSCVPESRYC 582
            .|||                   |.:|:. .|..:||..|....|:......|  .:|.......
Zfish   774 VIKYKGGYKDPVETVCSGQGNPTQMECMSPVCEESTGILSVDLDGAKDLQSQT--FTCHANGEPI 836

  Fly   583 PDHVCDPLEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNG-KCSCAPLDEEPK 646
            |....|.:.||:|   .||         ..|.:..|..:.|.....|...|| .|:...||.|..
Zfish   837 PFETEDRVLELSP---GQD---------EVSLHHKKLALVSGCMEIIMTVNGVDCNAKVLDNEIT 889

  Fly   647 MKKPRKRKNETEAEPLLGVRRGTP-----------------PNQPLQDPMLLGVLNVAGFECDRS 694
            .:.|   ||.|..      |:|.|                 .|..|...::||:|...|
Zfish   890 CRIP---KNLTIP------RQGAPVKVLVNREEHDIGMVVMKNSNLIVGVVLGILAAVG------ 939

  Fly   695 CMFFVITCPLLFVLLLLCLLIAQRK-----MLQRRLGKQSMTTSSKQ------------------ 736
                 :...:::|     .:..:||     :::.||...|..|:::.
Zfish   940 -----VGAAIVYV-----AMAQERKKKKAALVEVRLSMHSNRTTAENYDRSPDGDYRRETVRPAG 994

  Fly   737 --------------ALPESGGGDFALMPL------QSGFRFE----------SGDAKWEFPREKL 771
                          :||.:|..|.|..||      .|..|.:          |.|      :.|:
Zfish   995 LSVSPFHGSGTTFTSLPYAGSMDSAAAPLMRRQVSMSALRPDLLEEVKNVLISPD------KIKI 1053

  Fly   772 QLDTVLGEGEFGQVLKGFATEIAGLPGITTVAVKMLKKGSNSVEYMALLSEFQLLQEVSHPNVIK 836
            |.:.::|:|.||.|..|:.|:.....  |..|||.|.:.::..|....|.|...::...|.:|:.
Zfish  1054 QHEQIIGKGHFGTVYHGYLTDSDNKE--THCAVKSLNRITDLEEVEQFLREGLFMKAFHHSHVLS 1116

  Fly   837 LLGACTSSEA-PLLIIEYARYGSLRSYLRLSRKIECAGVDFADGVEPVNVKMVLTFAWQICKGMA 900
            |||....|:. ||:|:.|.::|.||.::|...:            .| .||.::.|..|:.|||.
Zfish  1117 LLGIVLPSDGLPLVILPYMKHGDLRHFIRSPER------------SP-TVKDLIGFGLQVAKGME 1168

  Fly   901 YLSELKLVHRDLAARNVLLADGKICKISDFGLTRDVYEDDAY-LKRSRD-RVPVKWMAPESLADH 963
            ||:..|.|||||||||.:|.:....|::|||:.||||:.:.| ::.|:. ::||||||.|||...
Zfish  1169 YLANKKFVHRDLAARNCMLDESFTVKVADFGMARDVYDKEYYSIQDSKKAKLPVKWMALESLQTQ 1233

  Fly   964 VYTSKSDVWSFGVLCWELITLGASPYPGIAPQNLWSLLKTGYRMDRPENCSEAVYSIVRTCWADE 1028
            .:|:||||||:|||.|||:|.||||||.:.|.::...|..|.|:.:|:.|.::::|::..||..|
Zfish  1234 KFTTKSDVWSYGVLMWELLTRGASPYPDVDPYDITPYLMQGRRLPQPQYCFDSLWSVLMQCWHPE 1298

  Fly  1029 PNGRPSFKFLASEFEKLLG--NNAKYIDLETNAVS 1061
            |..||.|..|....:.:..  :...||:|:...|:
Zfish  1299 PEKRPGFTTLVQAVQDIHSSLDGEHYINLQITYVN 1333

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	Protein Kinases, catalytic domain	770..1049	CDD:473864	106/283 (37%)
mst1ra	XP_005166175.1	Sema_MET_like	41..504	CDD:200509	52/327 (16%)
		PSI	507..549	CDD:396154	11/68 (16%)
		IPT	550..654	CDD:472823	22/111 (20%)
		IPT_plexin_repeat2	655..740	CDD:238584	16/94 (17%)
		IPT	742..828	CDD:214657	18/87 (21%)
		PTKc_Met_Ron	1057..1318	CDD:270649	104/275 (38%)