DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ret and fgfr4

DIOPT Version :9

Sequence 1:	NP_477044.1	Gene:	Ret / 43875	FlyBaseID:	FBgn0011829	Length:	1235	Species:	Drosophila melanogaster
Sequence 2:	NP_571505.1	Gene:	fgfr4 / 100000160	ZFINID:	ZDB-GENE-980526-488	Length:	922	Species:	Danio rerio

Alignment Length:	690	Identity:	208/690 - (30%)
Similarity:	313/690 - (45%)	Gaps:	161/690 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   460 IVEDKLGAFGITSTSGIVFVKNPQVLEEAPETIYFLNVTWIDQQRLSHVRVINVHLVHGRPENTS 524
            :||:|.|:...|                     |.|:|.    :|..|..::..    |.|:||:
Zfish   336 VVENKYGSIAHT---------------------YLLDVL----ERSPHRPILQA----GLPKNTT 371

  Fly   525 CELKVKSRSQTCAQIKYQSQCVRYCGLATGGGSCQWRGSNSAMFGTRYGSCVPESRYCPDHVCDP 589
            .  .|...:|...::...:|           ...||. .:..|.|:|||         ||.:
Zfish   372 A--IVGGDAQFLCKVYSDAQ-----------PHIQWL-KHIEMNGSRYG---------PDGI--- 410

  Fly   590 LEELNPMACPQDCTPAGRIVGPHSSNENKRGIYSASGTCICEDNGKCSC---------------A 639
                          |..:||...|.|.::..:...:...: ||.|:.||               .
Zfish   411 --------------PYVKIVKTGSLNMSEVEVLYLTNISM-EDAGEYSCLAGNSIGFSHQSAWLT 460

  Fly   640 PLDEEPKMKK-PRKRKNETEAEPLLGVRRGTPPNQPLQDPMLLGVLNVAGFECDRSCMFFVITCP 703
            .|.||...|: .......|:.                       ::..:||          :...
Zfish   461 VLSEEDVAKEVDLMEAKYTDI-----------------------IIYASGF----------LALV 492

  Fly   704 LLFVLLLLCLL-----------IAQRKMLQRRLGKQSMTTSSKQALPESGGGDFALM-------- 749
            :..|:::||.:           :..:|:.:..|.:|....|:     .||....:||
Zfish   493 MAIVIVVLCRMQVHPSREPFDTLPVQKLSKFPLRRQYSVESN-----SSGKSSASLMRVARLSSS 552

  Fly   750 --PLQSG-FRFE-SGDAKWEFPREKLQLDTVLGEGEFGQVLKGFATEI--AGLPGITTVAVKMLK 808
              |:.:| ..|| ..|..||||||.|.|...||||.||||::..|..|  .....:.||||||||
Zfish   553 CSPMLAGVMEFELPYDPDWEFPRENLTLGKPLGEGCFGQVVRAEAYGINKENQDHMATVAVKMLK 617

  Fly   809 KGSNSVEYMALLSEFQLLQEV-SHPNVIKLLGACTSSEAPLLIIEYARYGSLRSYLRLSRKIECA 872
            ..:...:...|:||.:|::.: .|.|:|.|||.||......:::|||..||||.|||..|.   .
Zfish   618 DDATDKDLADLISEMELMKVMDKHKNIINLLGVCTQDGPLYVLVEYASKGSLREYLRARRP---P 679

  Fly   873 GVDFADGV-----EPVNVKMVLTFAWQICKGMAYLSELKLVHRDLAARNVLLADGKICKISDFGL 932
            |:|:...|     |.:..|.:::.|:|:.:||.||:..:.:||||||||||:.:..:.||:||||
Zfish   680 GMDYTFDVTKVPEEQLTFKDLVSCAYQVARGMEYLASKRCIHRDLAARNVLVTEDNVMKIADFGL 744

  Fly   933 TRDVYEDDAYLKRSRDRVPVKWMAPESLADHVYTSKSDVWSFGVLCWELITLGASPYPGIAPQNL 997
            .|.|::.|.|.|.:..|:||||||||:|.|.|||.:|||||||||.||:.|||.||||||..:.|
Zfish   745 ARGVHQIDYYKKTTNGRMPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEEL 809

  Fly   998 WSLLKTGYRMDRPENCSEAVYSIVRTCWADEPNGRPSFKFLASEFEKLLGN-NAKYIDLETNAVS 1061
            :.|||.|:|||:|.||:..:|..:|.||...|..||:||.|..|.:::|.: :.:|:||.|....
Zfish   810 FKLLKEGHRMDKPSNCTHELYMKMRECWHAVPTQRPTFKQLVEELDRVLVSISDEYLDLSTPFEQ 874

  Fly  1062 NPLYCGDDSALITTELGEPESLQHLWSPPKIA--YDIHDQ 1099
            ....|.|.|:..:::.....:...|.:.|.:.  :|:|.:
Zfish   875 YSPSCEDTSSSCSSDNDSVFTHDALSTEPCLLGYHDVHSR 914

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ret	NP_477044.1	PKc_like	770..1049	CDD:304357	132/287 (46%)
Ret	NP_477044.1	TyrKc	771..1042	CDD:197581	130/278 (47%)
fgfr4	NP_571505.1	IG_like	44..135	CDD:214653
		Ig	52..136	CDD:299845
		IG_like	150..224	CDD:214653
		IGc2	156..212	CDD:197706
		Ig2_FGFR	268..352	CDD:143265	7/36 (19%)
		IG_like	273..352	CDD:214653	7/36 (19%)
		IG_like	367..461	CDD:214653	25/134 (19%)
		Ig3_FGFR-2	375..462	CDD:143266	21/125 (17%)
		PTKc_FGFR4	565..877	CDD:133230	143/314 (46%)
		Pkinase_Tyr	578..854	CDD:285015	130/278 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910