DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ras and IMD2

DIOPT Version :9

Sequence 1:	NP_001356940.1	Gene:	ras / 43873	FlyBaseID:	FBgn0003204	Length:	590	Species:	Drosophila melanogaster
Sequence 2:	NP_012088.3	Gene:	IMD2 / 856626	SGDID:	S000001259	Length:	523	Species:	Saccharomyces cerevisiae

Alignment Length:	515	Identity:	306/515 - (59%)
Similarity:	387/515 - (75%)	Gaps:	6/515 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 KSTTGFDAEL--QDGLSCKELFQN--GEGLTYNDFLILPGYIDFTAEEVDLSSPLTKSLTLRAPL 87
            |:...|...|  .||||.:||..:  ..||||||||||||.:||.:.||.|.:.||:::||..||
Yeast     8 KTALDFTKSLPRPDGLSVQELMDSKIRGGLTYNDFLILPGLVDFASSEVSLQTKLTRNITLNIPL 72

  Fly    88 VSSPMDTVTESEMAIAMALCGGIGIIHHNCTPEYQALEVHKVKKYKHGFMRDPSVMSPTNTVGDV 152
            ||||||||||||||..|||.||||.||||||||.||..|.:||.|::||:.:|.|:|||.|||:.
Yeast    73 VSSPMDTVTESEMATFMALLGGIGFIHHNCTPEDQADMVRRVKNYENGFINNPIVISPTTTVGEA 137

  Fly   153 LEARRKNGFTGYPVTENGKLGGKLLGMVTSRDIDFRENQPEVLLADIMTTELVTAPNGINLPTAN 217
            ...:.|.||.|:|||.:||...||:|::|||||.|.|:. .:|:.|:||...||...||.|...|
Yeast   138 KSMKEKYGFAGFPVTTDGKRNAKLVGVITSRDIQFVEDN-SLLVQDVMTKNPVTGAQGITLSEGN 201

  Fly   218 AILEKSKKGKLPIVNQAGELVAMIARTDLKKARSYPNASKDSN-KQLLVGAAIGTRSEDKARLAL 281
            .||:|.|||:|.:|::.|.||:|::||||.|.::||.|||.:| ||||.||:|||...||.||.|
Yeast   202 EILKKIKKGRLLVVDEKGNLVSMLSRTDLMKNQNYPLASKSANTKQLLCGASIGTMDADKERLRL 266

  Fly   282 LVANGVDVIILDSSQGNSVYQVEMIKYIKETYPELQVIGGNVVTRAQAKNLIDAGVDGLRVGMGS 346
            ||..|:||:|||||||||::::.|:|::||::|.|:||.||||||.||.|||.||.||||:|||:
Yeast   267 LVKAGLDVVILDSSQGNSIFELNMLKWVKESFPGLEVIAGNVVTREQAANLIAAGADGLRIGMGT 331

  Fly   347 GSICITQEVMACGCPQATAVYQVSTYARQFGVPVIADGGIQSIGHIVKAIALGASAVMMGSLLAG 411
            |||||||||||||.||.||||.|..:|.|||||.:||||:|:||||.||:|||:|.||||.:|||
Yeast   332 GSICITQEVMACGRPQGTAVYNVCEFANQFGVPCMADGGVQNIGHITKALALGSSTVMMGGMLAG 396

  Fly   412 TSEAPGEYFFSDGVRLKKYRGMGSLEAMERGDAKGAAMSRYYHNEMDKMKVAQGVSGSIVDKGSV 476
            |:|:|||||:.||.|||.||||||::||::...||.|.:..|.:|.|.:.|||||||::|||||:
Yeast   397 TTESPGEYFYQDGKRLKAYRGMGSIDAMQKTGTKGNASTSRYFSESDSVLVAQGVSGAVVDKGSI 461

  Fly   477 LRYLPYLECGLQHSCQDIGANSINKLRDMIYNGQLRFMKRTHSAQLEGNVHGLFSYEKRL 536
            .:::|||..||||||||||..|:..|::.:..|::||..||.||||||.||.|.||||||
Yeast   462 KKFIPYLYNGLQHSCQDIGCRSLTLLKNNVQRGKVRFEFRTASAQLEGGVHNLHSYEKRL 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ras	NP_001356940.1	PTZ00314	38..533	CDD:240355	298/497 (60%)
IMD2	NP_012088.3	PTZ00314	21..518	CDD:240355	298/497 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	589	1.000	Domainoid score	I27
eggNOG	1	0.900	-	-		E1_COG0516
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68096
Inparanoid	1	1.050	606	1.000	Inparanoid score	I129
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62889
OrthoFinder	1	1.000	-	-		FOG0001014
OrthoInspector	1	1.000	-	-		otm46774
orthoMCL	1	0.900	-	-		OOG6_100534
Panther	1	1.100	-	-	O	PTHR11911
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X605
TreeFam	1	0.960	-	-
	13	12.830